Thomas Bjarnsholt
Professor
Bacteriology
Nørre Allé 14
2200 København N
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Haematoxylin and eosin staining identifies medium to large bacterial aggregates with a reliable specificity: A comparative analysis of follicular bacterial aggregates in axillary biopsies using peptide nucleic acid-fluorescence in situ hybridization and haematoxylin and eosin staining
Ring, H. C., Riis, P. T., Bay, Lene, Kallenbach, K., Bjarnsholt, Thomas & Jemec, Gregor, Oct 2017, In: Experimental Dermatology. 26, 10, p. 943-945Research output: Contribution to journal › Letter › Research › peer-review
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Predictive metagenomic analysis identifies specific bacterial metabolic pathways in hidradenitis suppurativa tunnels
Ring, H. C., Thorsen, J., Lilje, B., Bay, Lene, Bjarnsholt, Thomas, Fuursted, K., Saunte, Ditte Marie, Jemec, Gregor & Thomsen, Simon Francis, 2024, In: Journal of the European Academy of Dermatology and Venereology. 38, 1, p. e63-e65Research output: Contribution to journal › Comment/debate › Research › peer-review
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Predictive Metagenomic Analysis Reveals a Role of Cutaneous Dysbiosis in the Development of Hidradenitis Suppurativa
Ring, H. C., Thorsen, Jonathan Jan Ilve, Jørgensen, A. H., Bay, Lene, Bjarnsholt, Thomas, Fuursted, K., Thomsen, Simon Francis & Jemec, Gregor, 2020, In: Journal of Investigative Dermatology. 140, 7, p. 1473-1476Research output: Contribution to journal › Letter › Research › peer-review
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The Limitations of In Vitro Experimentation in Understanding Biofilms and Chronic Infection
Roberts, A. E. L., Kragh, K. N., Bjarnsholt, Thomas & Diggle, S. P., 20 Nov 2015, In: Journal of Molecular Biology. 427, 23, p. 3646-3661 16 p.Research output: Contribution to journal › Review › Research › peer-review
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Detection of microorganisms involved in airway infection of cystic fibrosis patients by standard culturing 6 molecular methods
Rudkjøbing, V., Thomsen, T. R., Nielsen, P. H., Alhede, M., Johansen, U. R., Høiby, Niels & Bjarnsholt, Thomas, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, Jul 2011, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 236-244 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2011, In: Journal of Clinical Microbiology. 49, 12, p. 4352-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparing culture and molecular methods for the identification of microorganisms involved in necrotizing soft tissue infections
Rudkjøbing, V. B., Thomsen, T. R., Xu, Y., Melton-Kreft, R., Ahmed, A., Eickhardt-Dalbøge, S. R., Bjarnsholt, Thomas, Poulsen, Steen Seier, Nielsen, P. H., Earl, J. P., Ehrlich, G. D. & Moser, Claus Ernst, 8 Nov 2016, In: B M C Infectious Diseases. 16, 13 p., 652.Research output: Contribution to journal › Journal article › Research › peer-review
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Microbial Primer: In vivo biofilm
Rumbaugh, K. P. & Bjarnsholt, Thomas, 2023, In: Microbiology (United Kingdom). 169, 12, 5 p., 001407.Research output: Contribution to journal › Journal article › Research › peer-review
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The implication of Pseudomonas aeruginosa biofilms in infections
Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilms can act as plasmid reserves in the absence of plasmid specific selection
Røder, Henriette Lyng, Trivedi, Urvish, Russel, J., Kragh, K. N., Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: npj Biofilms and Microbiomes. 7, 6 p., 78.Research output: Contribution to journal › Letter › Research › peer-review
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Defining the temporal relationship between the skin microbiome, immune response and skin barrier function during flare and resolution of atopic dermatitis: protocol of a Danish intervention study
Rønnstad, A. T. M., Bay, Lene, Ruge, I. F., Halling, A., Fritz, Blaine Gabriel, Jakaša, I., Luiten, R., Kezic, S., Thomsen, Simon Francis, Bjarnsholt, Thomas & Thyssen, Jacob Pontoppidan, 2023, In: BMJ Open. 13, 2, 8 p., e068395.Research output: Contribution to journal › Journal article › Research › peer-review
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The biofilm life cycle: expanding the conceptual model of biofilm formation
Sauer, K., Stoodley, P., Goeres, D. M., Hall-Stoodley, L., Burmølle, Mette, Stewart, P. S. & Bjarnsholt, Thomas, 2022, In: Nature Reviews Microbiology. 20, 10, p. 608-620 13 p.Research output: Contribution to journal › Review › Research › peer-review
Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein
Schreiber, K., Boes, N., Eschbach, M., Jaensch, L., Wehland, J., Bjarnsholt, Thomas, Givskov, M., Hentzer, M. & Schobert, M., 2006, In: Journal of Bacteriology. 188, 2, p. 659-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Morphological evidence of biofilm in chronic obstructive sialadenitis
Schrøder, S. A., Eickhardt, S., Bjarnsholt, Thomas, Nørgaard, T. & Homøe, Preben, 2018, In: Journal of Laryngology and Otology. 132, 7, p. 611-614 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
Schultz, G., Bjarnsholt, Thomas, James, G. A., Leaper, D. J., McBain, A. J., Malone, M., Stoodley, P., Swanson, T., Tachi, M. & Wolcott, R. D., Sep 2017, In: Wound Repair and Regeneration. 25, 5, p. 744-757 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review
Schwarzer, S., James, G. A., Goeres, D., Bjarnsholt, Thomas, Vickery, K., Percival, S. L., Stoodley, P., Schultz, G., Jensen, S. O. & Malone, M., 2020, In: Journal of Infection. 80, 3, p. 261-270Research output: Contribution to journal › Review › Research › peer-review
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Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa
Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing antagonism from marine organisms
Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, Thomas, de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of two commercial broadrange PCR and sequencing assays for identification of bacteria in culture-negative clinical samples
Stavnsbjerg, Camilla, Frimodt-Moller, N., Moser, C. E. & Bjarnsholt, Thomas, 27 Mar 2017, In: B M C Infectious Diseases. 17, 7 p., 233.Research output: Contribution to journal › Journal article › Research › peer-review
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Methods for dynamic investigations of surface-attached in vitro bacterial and fungal biofilms
Sternberg, C., Bjarnsholt, Thomas & Shirtliff, M., 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 3-22 20 p.Research output: Contribution to journal › Journal article › Research
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Risk factors for chronic biofilm-related infection associated with implanted medical devices
Stewart, P. S. & Bjarnsholt, Thomas, 2020, In: Clinical Microbiology and Infection. 26, 8, p. 1034-1038Research output: Contribution to journal › Review › Research › peer-review
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Biofilm formation on endovascular aneurysm repair (EVAR) grafts- a proof of concept in vitro model
Sunnerhagen, T., Schwartz, F., Christophersen, L., Bjarnsholt, Thomas, Qvortrup, Klaus, Eldrup, Nikolaj, Vogt, K. & Moser, Claus Ernst, 2023, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 29, 12, p. 1600.e1-1600.e6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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IWII Wound Infection in Clinical Practice consensus document: 2022 update
Swanson, T., Ousey, K., Haesler, E., Bjarnsholt, Thomas, Carville, K., Idensohn, P., Kalan, L., Keast, D. H., Larsen, D., Percival, S., Schultz, G., Sussman, G., Waters, N. & Weir, D., 2022, In: Journal of Wound Care. 31, S12, p. S10-S21Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics
Sønderholm, M., Kragh, K. N., Koren, K., Jakobsen, Tim Holm, Darch, S., Alhede, M., Jensen, Peter Østrup, Whiteley, M., Kühl, Michael & Bjarnsholt, Thomas, May 2017, In: Applied and Environmental Microbiology. 83, 9, 15 p., e00113-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Tools for studying growth patterns and chemical dynamics of aggregated Pseudomonas aeruginosa exposed to different electron acceptors in an alginate bead model
Sønderholm, M., Koren, K., Wangpraseurt, D., Jensen, Peter Østrup, Kolpen, Mette, Kragh, K. N., Bjarnsholt, Thomas & Kühl, Michael, 2018, In: npj Biofilms and Microbiomes. 4, 11 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
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The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance
Sønderholm, M., Bjarnsholt, Thomas, Alhede, M., Kolpen, Mette, Jensen, Peter Østrup, Kühl, Michael & Kragh, K. N., 2017, In: International Journal of Molecular Sciences. 18, 12, 14 p., 2688.Research output: Contribution to journal › Review › Research › peer-review
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Acetic acid and a buffer
Bjarnsholt, Thomas, Givskov, Michael, P, H., Høiby, Niels, PO, J., HK, J. & K, K., 2010, Patent No. WO2009155931, 30 Jan 2010Research output: Patent
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A collagen-based layered chronic wound biofilm model for testing antimicrobial wound products
Thaarup, Ida Clement, Lichtenberg, Mads, Nørgaard, K. T. H., Xu, Y., Lorenzen, J., Thomsen, T. R. & Bjarnsholt, Thomas, 2023, In: Wound Repair and Regeneration. 31, 4, p. 500-515Research output: Contribution to journal › Journal article › Research › peer-review
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Measuring enzymatic degradation of degradable starch microspheres using confocal laser scanning microscopy
Thaarup, Ida Clement, Gummesson, C. & Bjarnsholt, Thomas, 2021, In: Acta Biomaterialia. 131, p. 464-471Research output: Contribution to journal › Journal article › Research › peer-review
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Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities
Thaarup, Ida Clement & Bjarnsholt, Thomas, 2021, In: Advances in Wound Care. 10, 2, p. 91-102 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilm Survival Strategies in Chronic Wounds
Thaarup, Ida Clement, Iversen, A. K. S., Lichtenberg, Mads, Bjarnsholt, Thomas & Jakobsen, Tim Holm, 2022, In: Microorganisms. 10, 4, 775.Research output: Contribution to journal › Review › Research › peer-review
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Anti-Pseudomonas aeruginosa IgY Antibodies Induce Specific Bacterial Aggregation and Internalization in Human Polymorphonuclear Neutrophils
Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Jul 2015, In: Infection and Immunity. 83, 7, p. 2686-2693 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model
Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Mar 2016, In: Journal of Cystic Fibrosis. 15, 2, p. 171-178 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils
Thomsen, K., Christophersen, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, Claus Ernst & Høiby, Niels, Jul 2016, In: Human Vaccines & Immunotherapeutics. 12, 7, p. 1690-1699 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The bacteriology of chronic venous leg ulcer examined by culture-independent molecular methods
Thomsen, T. R., Aasholm, M. S., Rudkjøbing, V. B., Saunders, A. M., Bjarnsholt, Thomas, Givskov, Michael, Kirketerp-Møller, K. & Nielsen, P. H., 2010, In: Wound Repair and Regeneration. 18, 1, p. 38-49 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa biofilm aggravates skin inflammatory response in BALB/c mice in a novel chronic wound model
Trøstrup, H., Thomsen, K., Christophersen, L. J., Hougen, H. P., Bjarnsholt, Thomas, Jensen, Peter Østrup, Kirkby, N., Calum, H., Høiby, Niels & Moser, Claus Ernst, Mar 2013, In: Wound Repair and Regeneration. 21, 2, p. 292-299 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis
Ulrich, M., Beer, I., Braitmaier, P., Dierkes, M., Kummer, F., Krismer, B., Schumacher, U., Gräpler-Mainka, U., Riethmüller, J., Jensen, Peter Østrup, Bjarnsholt, Thomas, Høiby, Niels, Bellon, G. & Döring, G., 1 Nov 2010, In: Thorax. 65, 11, p. 978-984 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alveolar inflammation in cystic fibrosis
Ulrich, M., Worlitzsch, D., Viglio, S., Siegmann, N., Iadarola, P., Shute, J. K., Geiser, M., Pier, G. B., Friedel, G., Barr, M. L., Schuster, A., Meyer, K. C., Ratjen, F., Bjarnsholt, Thomas, Gulbins, E. & Döring, G., 2010, In: Journal of Cystic Fibrosis. 9, 3, p. 217-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes
Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiotic susceptibility of cystic fibrosis lung microbiome members in a multispecies biofilm
Vandeplassche, E., Sass, A., Ostyn, L., Burmølle, Mette, Kragh, K. N., Bjarnsholt, Thomas, Coenye, T. & Crabbé, A., 2020, In: Biofilm. 2, 9 p., 100031.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of pig skin microbiome and appraisal as an in vivo subcutaneous injection model
Wareham-Mathiassen, S., Pinto Glenting, V., Bay, Lene, Allesen-Holm, M., Bengtsson, H. & Bjarnsholt, Thomas, 2023, In: Laboratory Animals. 57, 2, p. 304-318Research output: Contribution to journal › Journal article › Research › peer-review
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Injection site microflora in persons with diabetes: why needle reuse is not associated with increased infections?
Wareham-Mathiassen, S., Bay, Lene, Glenting, V. P., Fatima, N., Bengtsson, H. & Bjarnsholt, Thomas, 2022, In: APMIS. 130, 7, p. 404-416 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The phenotypic evolution of pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin
Wassermann, T., Jørgensen, K. M., Ivanyshyn, K., Bjarnsholt, Thomas, Hossein Khademi, S. M., Jelsbak, L., Høiby, Niels & Ciofu, Oana, 1 May 2016, In: Microbiology. 162, 5, p. 865-875 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An in vitro model of bacterial infections in wounds and other soft tissues
Werthén, M., Henriksson, L., Jensen, Peter Østrup, Sternberg, C., Givskov, Michael & Bjarnsholt, Thomas, 2010, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 118, 2, p. 156-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mucosal biofilm detection in chronic otitis media: a study of middle ear biopsies from Greenlandic patients
Wessman, M., Bjarnsholt, Thomas, Eickhardt-Sørensen, S. R., Johansen, Helle Krogh & Homøe, Preben, May 2015, In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 272, 5, p. 1079-1085 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin
Woetmann, Anders , Alhede, M., Dabelsteen, Sally, Bjarnsholt, Thomas, Rybtke, Morten Levin, Nastasi, C., Krejsgaard, T., Andersen, Mads Hald, Bonefeld, Charlotte Menne, Geisler, Carsten, Givskov, Michael & Ødum, Niels, 2018, In: OncoTarget. 9, 28, p. 19481-19489 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct sequencing and RipSeq interpretation as a tool for identification of polymicrobial infections
Wolff, T. Y., Eickhardt, S., Björnsdottir, M. K., Moser, Claus Ernst, Bjarnsholt, Thomas, Høiby, Niels & Thomsen, T. R., Apr 2013, In: Journal of Clinical Microbiology. 51, 4, p. 1281-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors
Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of the in vivo interaction of a P. aeruginosa biofilm & the innate host cellular response
van Gennip, M., Christensen, L. D., Qvortrup, K., Alhede, M., Jensen, Peter Østrup, Høiby, Niels, Givskov, M. & Bjarnsholt, Thomas, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
ID: 9755066
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Research output: Contribution to journal › Journal article › Research › peer-review
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