Tim Tolker-Nielsen
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N
Member of:
- Published
Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.
Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M. & Tolker-Nielsen, Tim, 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content
Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP
Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP
Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.Research output: Contribution to journal › Comment/debate › Research
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Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α‐synuclein and modulates its effect on biofilm formation
Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, Tim, Christiansen, G. & Otzen, D. E., May 2018, In: FEBS Letters. 592, 9, p. 1484-1496 13 p.Research output: Contribution to journal › Letter › Research › peer-review
Identification of a gene (mob14-3) encoding a mobilization protein from the Bacillus thuringiensis subsp. israelensis plasmid pTX14-3.
Andrup, L., Bolander, G., Boe, L., Madsen, S. M., Tolker-Nielsen, Tim & Wassermann, K., 1991, In: Nucleic Acids Research. 19, 10, p. 2780Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms
Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective proteomic analysis of antibiotic-tolerant cellular subpopulations in pseudomonas aeruginosa biofilms
Babin, B. M., Atangcho, L., van Eldijk, M. B., Sweredoski, M. J., Moradian, A., Hess, S., Tolker-Nielsen, Tim, Newman, D. K. & Tirrell, D. A., 2017, In: mBio. 8, 5, 16 p., e01593-17.Research output: Contribution to journal › Journal article › Research › peer-review
Advances in nucleic acid-based diagnostics of bacterial infections.
Barken, K. B., Haagensen, J. A. J. & Tolker-Nielsen, Tim, 2007, In: Clinica Chimica Acta. 384, 1-2, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms
Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry
Beilharz, K., Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim, Bjarnsholt, Thomas & Lichtenberg, Mads, 2023, In: STAR Protocols. 4, 2, 102269.Research output: Contribution to journal › Journal article › Research › peer-review
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The biofilm of Burkholderia cenocepacia H111 contains an exopolysaccharide composed of L-rhamnose and L-mannose: Structural characterization and molecular modelling
Bellich, B., Jou, I. A., Buriola, C., Ravenscroft, N., Brady, J. W., Fazli, M., Tolker-Nielsen, Tim, Rizzo, R. & Cescutti, P., 2021, In: Carbohydrate Research. 499, 108231.Research output: Contribution to journal › Journal article › Research › peer-review
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The Bep gene cluster in Burkholderia cenocepacia H111 codes for a water-insoluble exopolysaccharide essential for biofilm formation
Bellich, B., Terán, L. C., Fazli, M. M., Berti, F., Rizzo, R., Tolker-Nielsen, Tim & Cescutti, P., 2023, In: Carbohydrate Polymers. 301, 120318.Research output: Contribution to journal › Journal article › Research › peer-review
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Burkholderia cenocepacia h111 produces a water-insoluble exopolysaccharide in biofilm: Structural determination and molecular modelling
Bellich, B., Jou, I. A., Caterino, M., Rizzo, R., Ravenscroft, N., Fazli, M., Tolker-Nielsen, Tim, Brady, J. W. & Cescutti, P., 2020, In: International Journal of Molecular Sciences . 21, 5, 1702.Research output: Contribution to journal › Journal article › Research › peer-review
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Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115Research output: Contribution to journal › Journal article › Research › peer-review
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Interfering with bacterial gossip.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Quorum sensing inhibitors disable bacterial biofilms.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of extracellular matrix components in biofilm formation and adaptation of Pseudomonas ogarae F113 to the rhizosphere environment
Blanco-Romero, E., Garrido-Sanz, D., Durán, D., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Redondo-Nieto, M., Rivilla, R. & Martín, M., 2024, In: Frontiers in Microbiology. 15, 12 p., 1341728.Research output: Contribution to journal › Journal article › Research › peer-review
Plasmid stability: comments on the dimer catastrophe hypothesis.
Boe, L. & Tolker-Nielsen, Tim, 1997, In: Molecular Microbiology. 23, 2, p. 247-53 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cloning and characterization of two plasmids from Bacillus thuringiensis in Bacillus subtilis.
Boe, L., Tolker-Nielsen, Tim, Madsen, S. M., Andrup, L. & Bolander, G., 1991, In: Plasmid. 25, 3, p. 190-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli.
Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1994, In: Journal of Bacteriology. 176, 10, p. 2781-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli (Journal of Bacteriology 176:10 (2785))
Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1 Jan 1994, In: Journal of Bacteriology. 176, 14, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms
Bonnichsen, L., Svenningsen, N. B., Rybtke, Morten Levin, de Bruijn, I., Raaijmakers, J. M., Tolker-Nielsen, Tim & Nybroe, O., 2015, In: Microbiology. 161, 12, p. 2289-2297 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Architecture and spatial organization in a triple-species bacterial biofilm synergistically degrading the phenylurea herbicide linuron
Breugelmans, P., Barken, K. B., Tolker-Nielsen, Tim, Hofkens, J., Dejonghe, W. & Springael, D., May 2008, In: F E M S Microbiology Ecology. 64, 2, p. 271-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.Research output: Contribution to journal › Review › Research › peer-review
Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.
Caldwell, D. E., Colwell, R. R., Harayama, S., Kjelleberg, S., Givskov, M., Molin, S., Nielsen, A. T., Heydorn, A., Tolker-Nielsen, Tim, Sternberg, C., Nealson, K., Pace, N. R., Rainey, P., Stackebrandt, E., Tindall, B. J. & Stahl, D. A., 2000, In: Environmental Microbiology. 2, 1, p. 3-10 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
z A study of electroplated silver-palladium biofouling inhibiting coating.
Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Corrosion Engineering, Science and Technology. 43, 2, p. 142-148 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
z Bacteria inhibiting surfaces caused by the effects of silver release and/or electrical field.
Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, p. 108–115 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa
Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Bacterial inhibiting surfaces caused by the effects of silver release and/or electrical field
Chiang, W. C., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, 1, p. 108-115 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of silver additions to type 316 stainless steels on bacterial inhibition, mechanical properties, and corrosion resistance.
Chiang, W., Tseng, I., Møller, P., Rischel Hilbert, L., Tolker-Nielsen, Tim & Wu, J., 2010, In: Materials Chemistry and Physics. 119, p. 123–130 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Silver-palladium surfaces inhibit biofilm formation
Chiang, W., Schroll, C., Hilbert, L. R. & Tolker-Nielsen, Tim, 2009, In: Applied and Environmental Microbiology. 75, 6, p. 1674-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms
Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms
Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular DNA as matrix component in microbial biofilms.
Chiang, W. & Tolker-Nielsen, Tim, 2010, Extracellular Nucleic Acids.. Kikuchi, Y. & Rykova, E. (eds.). Springer Publishing Company, p. 1-14 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa
Chua, S. L., Liu, Y., Li, Y., Ting, H. J., Kohli, G. S., Cai, Z., Suwanchaikasem, P., Goh, K. K. K., Ng, S. P., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Oct 2017, In: Frontiers in Cellular and Infection Microbiology. 7, 8 p., 451.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms
Chua, S. L., Yam, J. K. H., Hao, P., Adav, S. S., Salido, M. M., Liu, Y., Givskov, Michael, Sze, S. K., Tolker-Nielsen, Tim & Yang, L., 2016, In: Nature Communications. 7, 11 p., 10750.Research output: Contribution to journal › Journal article › Research › peer-review
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Chua, S. L., Sivakumar, K., Rybtke, Morten Levin, Yuan, M., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim, Cao, B., Kjelleberg, S. & Yang, L., 2015, In: Scientific Reports. 5, 13 p., 10052.Research output: Contribution to journal › Journal article › Research › peer-review
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C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa
Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation
Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles
Chua, S. L., Liu, Y., Yam, J. K. H., Chen, Y., Vejborg, R. M., Tan, B. G. C., Kjelleberg, S., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Nature Communications. 5, p. 1-12 13 p., 4462.Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.Research output: Contribution to journal › Review › Research › peer-review
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Antibiotic tolerance and resistance in biofilms.
Ciofu, Oana & Tolker-Nielsen, Tim, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C., Jensen, P. Ø. & Høiby, N. (eds.). New York, USA: Springer Publishing Company, p. 215-230 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Antibiotic tolerance and resistance in biofilms
Ciofu, Oana & Tolker-Nielsen, Tim, 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Tolerance and resistance of pseudomonas aeruginosabiofilms to antimicrobial agents-how P. aeruginosa Can escape antibiotics
Ciofu, Oana & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 10, MAY, 15 p., 913.Research output: Contribution to journal › Review › Research › peer-review
ID: 8656938
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Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Research output: Contribution to journal › Review › Research › peer-review
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