Tim Tolker-Nielsen
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N
Member of:
- 1991
Cloning and characterization of two plasmids from Bacillus thuringiensis in Bacillus subtilis.
Boe, L., Tolker-Nielsen, Tim, Madsen, S. M., Andrup, L. & Bolander, G., 1991, In: Plasmid. 25, 3, p. 190-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a gene (mob14-3) encoding a mobilization protein from the Bacillus thuringiensis subsp. israelensis plasmid pTX14-3.
Andrup, L., Bolander, G., Boe, L., Madsen, S. M., Tolker-Nielsen, Tim & Wassermann, K., 1991, In: Nucleic Acids Research. 19, 10, p. 2780Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.
Tolker-Nielsen, Tim & Boe, L., 1994, In: Journal of Bacteriology. 176, 14, p. 4306-10 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli.
Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1994, In: Journal of Bacteriology. 176, 10, p. 2781-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli (Journal of Bacteriology 176:10 (2785))
Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1 Jan 1994, In: Journal of Bacteriology. 176, 14, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- 1996
Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium.
Tolker-Nielsen, Tim & Molin, S., 1996, In: FEMS Microbiology Letters. 142, 2-3, p. 155-60 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
Effects of stress treatments on the detection of Salmonella typhimurium by in situ hybridization.
Tolker-Nielsen, Tim, Larsen, M. H., Kyed, H. & Molin, S., 1997, In: International Journal of Food Microbiology. 35, 3, p. 251-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Plasmid stability: comments on the dimer catastrophe hypothesis.
Boe, L. & Tolker-Nielsen, Tim, 1997, In: Molecular Microbiology. 23, 2, p. 247-53 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Visualization of specific gene expression in individual Salmonella typhimurium cells by in situ PCR.
Tolker-Nielsen, Tim, Holmstrøm, K. & Molin, S., 1997, In: Applied and Environmental Microbiology. 63, 11, p. 4196-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
Biased 16S rDNA PCR amplification caused by interference from DNA flanking the template region.
Hansen, M. C., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 1998, In: FEMS Microbiology Ecology. 26, p. 141-149 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Non-genetic population heterogeneity studied by in situ polymerase chain reaction.
Tolker-Nielsen, Tim, Holmstrøm, K., Boe, L. & Molin, S., 1998, In: Molecular Microbiology. 27, 6, p. 1099-105 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.
Licht, T. R., Tolker-Nielsen, Tim, Holmstrøm, K., Krogfelt, K. & Molin, S., 1999, In: Environmental Microbiology. 1, 1, p. 23-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Physiological states of individual Salmonella typhimurium cells monitored by in situ reverse transcription-PCR.
Hølmstrom, K., Tolker-Nielsen, Tim & Molin, S., 1999, In: Journal of Bacteriology. 181, 6, p. 1733-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells.
Tolker-Nielsen, Tim, Christensen, A. B., Holmstrøm, K., Eberl, L., Rasmussen, T. B., Sternberg, C., Heydorn, A., Molin, S. & Givskov, M., 2000, In: Journal of Bacteriology. 182, 10, p. 2680-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.
Caldwell, D. E., Colwell, R. R., Harayama, S., Kjelleberg, S., Givskov, M., Molin, S., Nielsen, A. T., Heydorn, A., Tolker-Nielsen, Tim, Sternberg, C., Nealson, K., Pace, N. R., Rainey, P., Stackebrandt, E., Tindall, B. J. & Stahl, D. A., 2000, In: Environmental Microbiology. 2, 1, p. 3-10 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and dynamics of Pseudomonas sp. biofilms.
Tolker-Nielsen, Tim, Brinch, U. C., Ragas, P. C., Andersen, J. B., Jacobsen, C. S. & Molin, S., 2000, In: Journal of Bacteriology. 182, 22, p. 6482-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells.
Lange, M., Tolker-Nielsen, Tim, Molin, S. & Ahring, B. K., 2000, In: Applied and Environmental Microbiology. 66, 5, p. 1796-800 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular ecology of biofilms.
Molin, S., Nielsen, A. T., Christensen, B. B., Andersen, J. B., Licht, T. R., Tolker-Nielsen, Tim, Sternberg, C., Hansen, M. C., Ramos, C. & Givskov, M., 2000, Biofilms.. Wiley, p. 89-120Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Role of commensal relationships on the spatial structure of a surface-attached microbial consortium.
Nielsen, A. T., Tolker-Nielsen, Tim, Barken, K. B. & Molin, S., 2000, In: Environmental Microbiology. 2, 1, p. 59-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Spatial Organization of Microbial Biofilm Communities.
Tolker-Nielsen, Tim & Molin, S., 2000, In: Microbial Ecology. 40, 2, p. 75-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Extracellular DNA required for bacterial biofilm formation.
Whitchurch, C. B., Tolker-Nielsen, Tim, Ragas, P. C. & Mattick, J. S., 2002, In: Science. 295, 5559, p. 1487Research output: Contribution to journal › Journal article › Research › peer-review
Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.
Heydorn, A., Ersbøll, B., Kato, J., Hentzer, M., Parsek, M. R., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 2002, In: Applied and Environmental Microbiology. 68, 4, p. 2008-17 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants.
Klausen, M., Heydorn, A., Ragas, P., Lambertsen, L., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 48, 6, p. 1511-24 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cell death in Pseudomonas aeruginosa biofilm development.
Webb, J. S., Thompson, L. S., James, S., Charlton, T., Tolker-Nielsen, Tim, Koch, B., Givskov, M. & Kjelleberg, S., 2003, In: Journal of Bacteriology. 185, 15, p. 4585-92 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure.
Molin, S. & Tolker-Nielsen, Tim, 2003, In: Current Opinion in Biotechnology. 14, 3, p. 255-61 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms.
Klausen, M., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 50, 1, p. 61-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Biofilm development by pseudomonads.
Tolker-Nielsen, Tim & Molin, S., 2004, Environmental Biotechnology. Verstraete, W. (ed.). CRC Press/Balkema, p. 27-32Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Microbial interactions in mixed-species biofilms.
Molin, S., Tolker-Nielsen, Tim & Hansen, S. K., 2004, Microbial biofilms.. Ghannoum, M. & O’Toole, G. A. (eds.). ASM International, p. 206-221Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
The biofilm lifestyle of pseudomonads.
Tolker-Nielsen, Tim & Molin, S., 2004, Pseudomonas. Ramos, J. (ed.). Kluwer Academic Publishers, p. 547-571Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 2005
Characterization of starvation-induced dispersion in Pseudomonas putida biofilms.
Gjermansen, M., Ragas, P., Sternberg, C., Molin, S. & Tolker-Nielsen, Tim, 2005, In: Environmental Microbiology. 7, 6, p. 894-906 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Microbial pathogenesis and biofilm development.
Reisner, A., Høiby, N., Tolker-Nielsen, Tim & Molin, S., 2005, In: Contributions to Microbiology. 12, p. 114-31 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.
Whitchurch, C. B., Beatson, S. A., Comolli, J. C., Jakobsen, T., Sargent, J. L., Bertrand, J. J., West, J., Klausen, M., Waite, L. L., Kang, P. J., Tolker-Nielsen, Tim, Mattick, J. S. & Engel, J. N., 2005, In: Molecular Microbiology. 55, 5, p. 1357-78 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.
Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M. & Tolker-Nielsen, Tim, 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.
Haagensen, J. A. J., Klausen, M., Ernst, R. K., Miller, S. I., Folkesson, A., Tolker-Nielsen, Tim & Molin, S., 2006, In: Journal of Bacteriology. 189, 1, p. 28-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms.
Klausen, M., Gjermansen, M., Kreft, J. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 261, 1, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Growing and analyzing biofilms in flow cells.
Sternberg, C. & Tolker-Nielsen, Tim, 2006, In: Current Protocols in Microbiology. Chapter 1, p. Unit 1B.2Research output: Contribution to journal › Journal article › Research › peer-review
Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal.
Gjermansen, M., Ragas, P. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 265, 2, p. 215-24 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Advances in nucleic acid-based diagnostics of bacterial infections.
Barken, K. B., Haagensen, J. A. J. & Tolker-Nielsen, Tim, 2007, In: Clinica Chimica Acta. 384, 1-2, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6.
Hansen, S. K., Haagensen, J. A. J., Gjermansen, M., Jørgensen, T. M., Tolker-Nielsen, Tim & Molin, S., 2007, In: Journal of Bacteriology. 189, 13, p. 4932-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.
Eckhart, L., Fischer, H., Barken, K. B., Tolker-Nielsen, Tim & Tschachler, E., 2007, In: British Journal of Dermatology. 156, 6, p. 1342-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.
Yang, L., Barken, K. B., Skindersoe, M. E., Christensen, A. B., Givskov, M. & Tolker-Nielsen, Tim, 2007, In: Microbiology. 153, Pt 5, p. 1318-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa.
Li, Y., Xia, H., Bai, F., Xu, H., Yang, L., Yao, H., Zhang, L., Zhang, X., Bai, Y., Saris, P. E. J., Tolker-Nielsen, Tim & Qiao, M., 2007, In: FEMS Microbiology Letters. 272, 2, p. 188-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Microbial motility involvement in biofilm structure formation--a 3D modelling study.
Picioreanu, C., Kreft, J. U., Klausen, M., Haagensen, J. A. J., Tolker-Nielsen, Tim & Molin, S., 2007, In: Water Science and Technology. 55, 8-9, p. 337-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.
Pamp, S. J. & Tolker-Nielsen, Tim, 2007, In: Journal of Bacteriology. 189, 6, p. 2531-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.
Qin, Z., Ou, Y., Yang, L., Zhu, Y., Tolker-Nielsen, Tim, Molin, S. & Qu, D., 2007, In: Microbiology. 153, Pt 7, p. 2083-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The biofilm matrix - A sticky framework.
Pamp, S., Gjermansen, M. & Tolker-Nielsen, Tim, 2007, The biofilm mode of life - Mechanisms and adaptations.. Kjelleberg, S. & Givskov, M. (eds.). HorizonBioscience, p. 37-69Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 2008
Bacterial inhibiting surfaces caused by the effects of silver release and/or electrical field
Chiang, W. C., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, 1, p. 108-115 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.
Ryan, R. P., Fouhy, Y., Garcia, B. F., Watt, S. A., Niehaus, K., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2008, In: Molecular Microbiology. 68, 1, p. 75-86 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pattern formation in Pseudomonas aeruginosa biofilms.
Parsek, M. R. & Tolker-Nielsen, Tim, 2008, In: Current Opinion in Microbiology. 11, p. 560-566 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pseudomonas aeruginosa: A Model for Biofilm Formation
McDougald, D., Klebensberger, J., Tolker-Nielsen, Tim, Webb, J. S., Conibear, T., Rice, S. A., Kirov, S. M., Matz, C. & Kjelleberg, S., 2008, Pseudomonas. Model Organism, Pathogen, Cell Factory.. Rehm, B. H. A. (ed.). Wiley-VCH, p. 215-254 40 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
ID: 8656938
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Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
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