Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

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    ORCID: 0000-0002-9751-474X

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    1. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.

      Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M. & Tolker-Nielsen, Tim, 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

      Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.

      Research output: Contribution to journal › Comment/debate › Research

    6. Published

      Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α‐synuclein and modulates its effect on biofilm formation

      Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, Tim, Christiansen, G. & Otzen, D. E., May 2018, In: FEBS Letters. 592, 9, p. 1484-1496 13 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    9. Identification of a gene (mob14-3) encoding a mobilization protein from the Bacillus thuringiensis subsp. israelensis plasmid pTX14-3.

      Andrup, L., Bolander, G., Boe, L., Madsen, S. M., Tolker-Nielsen, Tim & Wassermann, K., 1991, In: Nucleic Acids Research. 19, 10, p. 2780

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

      Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Selective proteomic analysis of antibiotic-tolerant cellular subpopulations in pseudomonas aeruginosa biofilms

      Babin, B. M., Atangcho, L., van Eldijk, M. B., Sweredoski, M. J., Moradian, A., Hess, S., Tolker-Nielsen, Tim, Newman, D. K. & Tirrell, D. A., 2017, In: mBio. 8, 5, 16 p., e01593-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Advances in nucleic acid-based diagnostics of bacterial infections.

      Barken, K. B., Haagensen, J. A. J. & Tolker-Nielsen, Tim, 2007, In: Clinica Chimica Acta. 384, 1-2, p. 1-11 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms

      Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry

      Beilharz, K., Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim, Bjarnsholt, Thomas & Lichtenberg, Mads, 2023, In: STAR Protocols. 4, 2, 102269.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      The biofilm of Burkholderia cenocepacia H111 contains an exopolysaccharide composed of L-rhamnose and L-mannose: Structural characterization and molecular modelling

      Bellich, B., Jou, I. A., Buriola, C., Ravenscroft, N., Brady, J. W., Fazli, M., Tolker-Nielsen, Tim, Rizzo, R. & Cescutti, P., 2021, In: Carbohydrate Research. 499, 108231.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The Bep gene cluster in Burkholderia cenocepacia H111 codes for a water-insoluble exopolysaccharide essential for biofilm formation

      Bellich, B., Terán, L. C., Fazli, M. M., Berti, F., Rizzo, R., Tolker-Nielsen, Tim & Cescutti, P., 2023, In: Carbohydrate Polymers. 301, 120318.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Burkholderia cenocepacia h111 produces a water-insoluble exopolysaccharide in biofilm: Structural determination and molecular modelling

      Bellich, B., Jou, I. A., Caterino, M., Rizzo, R., Ravenscroft, N., Fazli, M., Tolker-Nielsen, Tim, Brady, J. W. & Cescutti, P., 2020, In: International Journal of Molecular Sciences . 21, 5, 1702.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Interfering with bacterial gossip.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    21. Published

      Quorum sensing inhibitors disable bacterial biofilms.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    22. Published

      Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Role of extracellular matrix components in biofilm formation and adaptation of Pseudomonas ogarae F113 to the rhizosphere environment

      Blanco-Romero, E., Garrido-Sanz, D., Durán, D., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Redondo-Nieto, M., Rivilla, R. & Martín, M., 2024, In: Frontiers in Microbiology. 15, 12 p., 1341728.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Plasmid stability: comments on the dimer catastrophe hypothesis.

      Boe, L. & Tolker-Nielsen, Tim, 1997, In: Molecular Microbiology. 23, 2, p. 247-53 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Cloning and characterization of two plasmids from Bacillus thuringiensis in Bacillus subtilis.

      Boe, L., Tolker-Nielsen, Tim, Madsen, S. M., Andrup, L. & Bolander, G., 1991, In: Plasmid. 25, 3, p. 190-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli.

      Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1994, In: Journal of Bacteriology. 176, 10, p. 2781-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Erratum: Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli (Journal of Bacteriology 176:10 (2785))

      Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1 Jan 1994, In: Journal of Bacteriology. 176, 14, 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    28. Published

      Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms

      Bonnichsen, L., Svenningsen, N. B., Rybtke, Morten Levin, de Bruijn, I., Raaijmakers, J. M., Tolker-Nielsen, Tim & Nybroe, O., 2015, In: Microbiology. 161, 12, p. 2289-2297 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Architecture and spatial organization in a triple-species bacterial biofilm synergistically degrading the phenylurea herbicide linuron

      Breugelmans, P., Barken, K. B., Tolker-Nielsen, Tim, Hofkens, J., Dejonghe, W. & Springael, D., May 2008, In: F E M S Microbiology Ecology. 64, 2, p. 271-82 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

      Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    31. Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.

      Caldwell, D. E., Colwell, R. R., Harayama, S., Kjelleberg, S., Givskov, M., Molin, S., Nielsen, A. T., Heydorn, A., Tolker-Nielsen, Tim, Sternberg, C., Nealson, K., Pace, N. R., Rainey, P., Stackebrandt, E., Tindall, B. J. & Stahl, D. A., 2000, In: Environmental Microbiology. 2, 1, p. 3-10 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. z A study of electroplated silver-palladium biofouling inhibiting coating.

      Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Corrosion Engineering, Science and Technology. 43, 2, p. 142-148 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. z Bacteria inhibiting surfaces caused by the effects of silver release and/or electrical field.

      Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, p. 108–115 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

      Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Bacterial inhibiting surfaces caused by the effects of silver release and/or electrical field

      Chiang, W. C., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, 1, p. 108-115 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

      Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Silver-palladium surfaces inhibit biofilm formation

      Chiang, W., Schroll, C., Hilbert, L. R. & Tolker-Nielsen, Tim, 2009, In: Applied and Environmental Microbiology. 75, 6, p. 1674-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

      Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Extracellular DNA as matrix component in microbial biofilms.

      Chiang, W. & Tolker-Nielsen, Tim, 2010, Extracellular Nucleic Acids.. Kikuchi, Y. & Rykova, E. (eds.). Springer Publishing Company, p. 1-14 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    40. Published

      Influence of silver additions to type 316 stainless steels on bacterial inhibition, mechanical properties, and corrosion resistance.

      Chiang, W., Tseng, I., Møller, P., Rischel Hilbert, L., Tolker-Nielsen, Tim & Wu, J., 2010, In: Materials Chemistry and Physics. 119, p. 123–130 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

      Chua, S. L., Liu, Y., Yam, J. K. H., Chen, Y., Vejborg, R. M., Tan, B. G. C., Kjelleberg, S., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Nature Communications. 5, p. 1-12 13 p., 4462.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

      Chua, S. L., Sivakumar, K., Rybtke, Morten Levin, Yuan, M., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim, Cao, B., Kjelleberg, S. & Yang, L., 2015, In: Scientific Reports. 5, 13 p., 10052.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms

      Chua, S. L., Yam, J. K. H., Hao, P., Adav, S. S., Salido, M. M., Liu, Y., Givskov, Michael, Sze, S. K., Tolker-Nielsen, Tim & Yang, L., 2016, In: Nature Communications. 7, 11 p., 10750.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa

      Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

      Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa

      Chua, S. L., Liu, Y., Li, Y., Ting, H. J., Kohli, G. S., Cai, Z., Suwanchaikasem, P., Goh, K. K. K., Ng, S. P., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Oct 2017, In: Frontiers in Cellular and Infection Microbiology. 7, 8 p., 451.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

      Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      Antibiotic tolerance and resistance in biofilms.

      Ciofu, Oana & Tolker-Nielsen, Tim, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C., Jensen, P. Ø. & Høiby, N. (eds.). New York, USA: Springer Publishing Company, p. 215-230 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    49. Published

      Antibiotic tolerance and resistance in biofilms

      Ciofu, Oana & Tolker-Nielsen, Tim, 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    50. Published

      Tolerance and resistance of pseudomonas aeruginosabiofilms to antimicrobial agents-how P. aeruginosa Can escape antibiotics

      Ciofu, Oana & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 10, MAY, 15 p., 913.

      Research output: Contribution to journal › Review › Research › peer-review

    51. Published

      Bursting the bubble on bacterial biofilms: a flow cell methodology

      Crusz, S. A., Popat, R., Rybtke, Morten Levin, Cámara, M., Givskov, Michael, Tolker-Nielsen, Tim, Diggle, S. P. & Williams, P., 2012, In: Biofouling. 28, 8, p. 835-842 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Viable Bacteria Associated with Red Blood Cells and Plasma in Freshly Drawn Blood Donations

      Damgaard, Christian, Magnussen, K., Enevold, Christian, Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim, Holmstrup, Palle & Nielsen, Claus Henrik, 9 Mar 2015, In: P L o S One. 10, 3, p. 1-9 9 p., e0120826.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation

      Dueholm, M. S., Søndergaard, M., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, Michael, Tolker-Nielsen, Tim, Otzen, D. & Nielsen, P. H., 18 Mar 2013, In: MicrobiologyOpen. 2, p. 365-382 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.

      Eckhart, L., Fischer, H., Barken, K. B., Tolker-Nielsen, Tim & Tschachler, E., 2007, In: British Journal of Dermatology. 156, 6, p. 1342-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      In-frame and unmarked gene deletions in Burkholderia cenocepacia via an allelic exchange system compatible with gateway technology

      Fazli, M., Harrison, J. J., Gambino, M., Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Applied and Environmental Microbiology. 81, 11, p. 3623-3630 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Regulation of biofilm formation in Pseudomonas and Burkholderia species

      Fazli, M., Almblad, H., Rybtke, Morten Levin, Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2014, In: Environmental Microbiology. 16, 7, p. 1961-1981 21 p.

      Research output: Contribution to journal › Review › Research › peer-review

    57. Published

      Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB

      Fazli, M., Rybtke, Morten Levin, Steiner, E., Weidel, E., Berthelsen, J., Groizeleau, J. D. D., Bin, W., Zhi, B. Z., Yaming, Z., Kaever, V., Givskov, Michael, Hartmann, R. W., Eberl, L. & Tolker-Nielsen, Tim, 2017, In: MicrobiologyOpen. 6, 4, 13 p., e00480.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

      Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, B., Andersen, A. S., Krogfelt, K. A., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Journal of Clinical Microbiology. 47, 12, p. 4084-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, A., Andersen, C. B., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Wound Repair and Regeneration. 19, 3, p. 387-91 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349

      Fazli, M., McCarthy, Y., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, Feb 2013, In: MicrobiologyOpen. 2, 1, p. 105-122 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

      Fazli, M., O'Connell, A., Nilsson, M., Niehaus, K., Dow, J. M., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, 2011, In: Molecular Microbiology. 82, 2, p. 327-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

      Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms

      Gjermansen, M., Nilsson, Carl Martin Peter, Yang, L. & Tolker-Nielsen, Tim, 2010, In: Molecular Microbiology. 75, 4, p. 815-26 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal.

      Gjermansen, M., Ragas, P. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 265, 2, p. 215-24 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Characterization of starvation-induced dispersion in Pseudomonas putida biofilms.

      Gjermansen, M., Ragas, P., Sternberg, C., Molin, S. & Tolker-Nielsen, Tim, 2005, In: Environmental Microbiology. 7, 6, p. 894-906 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Importance of the exopolysaccharide matrix in antimicrobial tolerance of Pseudomonas aeruginosa aggregates

      Goltermann, Lise & Tolker-Nielsen, Tim, Apr 2017, In: Antimicrobial Agents and Chemotherapy. 61, 4, 7 p., e02696.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      High-throughput screening for compounds that modulate the cellular c-di-GMP level in bacteria

      Groizeleau, J., Andersen, Jens Bo, Givskov, Michael, Berthelsen, J. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 455-470 16 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    69. Published

      The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

      Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials

      Gulez, G., Altintas, A., Fazli, M., Dechesne, A., Workman, C., Tolker-Nielsen, Tim & Smets, B. F., 2014, In: MicrobiologyOpen. 3, 4, p. 457-469

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Challenges in using transcriptome data to study the c-di-GMP signaling network in Pseudomonas aeruginosa clinical isolates

      Gür, M., Erdmann, J., Will, A., Liang, Z., Andersen, Jens Bo, Tolker-Nielsen, Tim & Häussler, S., 2023, In: FEMS Microbes. 4, 10 p., xtad012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.

      Haagensen, J. A. J., Klausen, M., Ernst, R. K., Miller, S. I., Folkesson, A., Tolker-Nielsen, Tim & Molin, S., 2006, In: Journal of Bacteriology. 189, 1, p. 28-37 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      A possible correlation between periodontitis and ischaemic heart disease

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

      Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

      Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Biased 16S rDNA PCR amplification caused by interference from DNA flanking the template region.

      Hansen, M. C., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 1998, In: FEMS Microbiology Ecology. 26, p. 141-149 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

      Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

      Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6.

      Hansen, S. K., Haagensen, J. A. J., Gjermansen, M., Jørgensen, T. M., Tolker-Nielsen, Tim & Molin, S., 2007, In: Journal of Bacteriology. 189, 13, p. 4932-43 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal

      Harmsen, M., Yang, L., Pamp, S. J. & Tolker-Nielsen, Tim, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 253-68 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Sub-lethal antimicrobial photodynamic inactivation affects Pseudomonas aeruginosa PAO1 quorum sensing and cyclic di-GMP regulatory systems

      Hendiani, S., Rybtke, Morten Levin, Tolker-Nielsen, Tim & Kashef, N., 2019, In: Photodiagnosis and Photodynamic Therapy. 27, p. 467-473 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

      Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.

      Heydorn, A., Ersbøll, B., Kato, J., Hentzer, M., Parsek, M. R., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 2002, In: Applied and Environmental Microbiology. 68, 4, p. 2008-17 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

      Hmelo, L. R., Borlee, B. R., Almblad, H., Love, M. E., Randall, T. E., Tseng, B. S., Lin, C., Irie, Y., Storek, K. M., Yang, J. J., Siehnel, R. J., Howell, P. L., Singh, P. K., Tolker-Nielsen, Tim, Parsek, M. R., Schweizer, H. P. & Harrison, J. J., Nov 2015, In: Nature Protocols (Print). 10, 11, p. 1820-41 22 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity

      Hoong Yam, J. K., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Santillan Salido, M. M., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Wu, B., Kjelleberg, S., Tolker-Nielsen, Tim, Beuerman, R. W., Givskov, Michael & Yang, L., 2017, bioRxiv, 35 p.

      Research output: Working paper › Preprint › Research

    87. Published

      Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

      Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      The clinical impact of bacterial biofilms

      Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Physiological states of individual Salmonella typhimurium cells monitored by in situ reverse transcription-PCR.

      Hølmstrom, K., Tolker-Nielsen, Tim & Molin, S., 1999, In: Journal of Bacteriology. 181, 6, p. 1733-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      A broad range quorum sensing inhibitor working through sRNA inhibition

      Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

      Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

      Research output: Contribution to journal › Review › Research › peer-review

    92. Published

      SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

      Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Report from Eurobiofilms 2011

      Jensen, Peter Østrup & Tolker-Nielsen, Tim, 2011, In: Future Microbiology. 6, 11, p. 1237-45

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      Two FtsH proteases contribute to fitness and adaptation of pseudomonas aeruginosa Clone C strains

      Kamal, S. M., Rybtke, Morten Levin, Nimtz, M., Sperlein, S., Giske, C., Trček, J., Deschamps, J., Briandet, R., Dini, L., Jänsch, L., Tolker-Nielsen, Tim, Lee, C. & Römling, U., 2019, In: Frontiers in Microbiology. 10, JULY, 18 p., 1372.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Distribution, organization, and ecology of bacteria in chronic wounds

      Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, M., Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms.

      Klausen, M., Gjermansen, M., Kreft, J. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 261, 1, p. 1-11 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms.

      Klausen, M., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 50, 1, p. 61-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants.

      Klausen, M., Heydorn, A., Ragas, P., Lambertsen, L., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 48, 6, p. 1511-24 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Bacteria-triggered release of antimicrobial agents

      Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      The non-attached biofilm aggregate

      Kragh, K. N., Tolker-Nielsen, Tim & Lichtenberg, Mads, 2023, In: Communications Biology . 6, 898.

      Research output: Contribution to journal › Review › Research › peer-review

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