Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

Member of:


    1. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.

      Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M. & Tolker-Nielsen, Tim, 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

      Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.

      Research output: Contribution to journalComment/debateResearch

    6. Published

      Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α‐synuclein and modulates its effect on biofilm formation

      Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, Tim, Christiansen, G. & Otzen, D. E., May 2018, In: FEBS Letters. 592, 9, p. 1484-1496 13 p.

      Research output: Contribution to journalLetterResearchpeer-review

    9. Identification of a gene (mob14-3) encoding a mobilization protein from the Bacillus thuringiensis subsp. israelensis plasmid pTX14-3.

      Andrup, L., Bolander, G., Boe, L., Madsen, S. M., Tolker-Nielsen, Tim & Wassermann, K., 1991, In: Nucleic Acids Research. 19, 10, p. 2780

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

      Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Selective proteomic analysis of antibiotic-tolerant cellular subpopulations in pseudomonas aeruginosa biofilms

      Babin, B. M., Atangcho, L., van Eldijk, M. B., Sweredoski, M. J., Moradian, A., Hess, S., Tolker-Nielsen, Tim, Newman, D. K. & Tirrell, D. A., 2017, In: mBio. 8, 5, 16 p., e01593-17.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Advances in nucleic acid-based diagnostics of bacterial infections.

      Barken, K. B., Haagensen, J. A. J. & Tolker-Nielsen, Tim, 2007, In: Clinica Chimica Acta. 384, 1-2, p. 1-11 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms

      Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry

      Beilharz, K., Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim, Bjarnsholt, Thomas & Lichtenberg, Mads, 2023, In: STAR Protocols. 4, 2, 102269.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      The biofilm of Burkholderia cenocepacia H111 contains an exopolysaccharide composed of L-rhamnose and L-mannose: Structural characterization and molecular modelling

      Bellich, B., Jou, I. A., Buriola, C., Ravenscroft, N., Brady, J. W., Fazli, M., Tolker-Nielsen, Tim, Rizzo, R. & Cescutti, P., 2021, In: Carbohydrate Research. 499, 108231.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      The Bep gene cluster in Burkholderia cenocepacia H111 codes for a water-insoluble exopolysaccharide essential for biofilm formation

      Bellich, B., Terán, L. C., Fazli, M. M., Berti, F., Rizzo, R., Tolker-Nielsen, Tim & Cescutti, P., 2023, In: Carbohydrate Polymers. 301, 120318.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Burkholderia cenocepacia h111 produces a water-insoluble exopolysaccharide in biofilm: Structural determination and molecular modelling

      Bellich, B., Jou, I. A., Caterino, M., Rizzo, R., Ravenscroft, N., Fazli, M., Tolker-Nielsen, Tim, Brady, J. W. & Cescutti, P., 2020, In: International Journal of Molecular Sciences . 21, 5, 1702.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Interfering with bacterial gossip.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    21. Published

      Quorum sensing inhibitors disable bacterial biofilms.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    22. Published

      Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Role of extracellular matrix components in biofilm formation and adaptation of Pseudomonas ogarae F113 to the rhizosphere environment

      Blanco-Romero, E., Garrido-Sanz, D., Durán, D., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Redondo-Nieto, M., Rivilla, R. & Martín, M., 2024, In: Frontiers in Microbiology. 15, 12 p., 1341728.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Plasmid stability: comments on the dimer catastrophe hypothesis.

      Boe, L. & Tolker-Nielsen, Tim, 1997, In: Molecular Microbiology. 23, 2, p. 247-53 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Cloning and characterization of two plasmids from Bacillus thuringiensis in Bacillus subtilis.

      Boe, L., Tolker-Nielsen, Tim, Madsen, S. M., Andrup, L. & Bolander, G., 1991, In: Plasmid. 25, 3, p. 190-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli.

      Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1994, In: Journal of Bacteriology. 176, 10, p. 2781-7 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Erratum: Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli (Journal of Bacteriology 176:10 (2785))

      Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1 Jan 1994, In: Journal of Bacteriology. 176, 14, 1 p.

      Research output: Contribution to journalComment/debateResearchpeer-review

    28. Published

      Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms

      Bonnichsen, L., Svenningsen, N. B., Rybtke, Morten Levin, de Bruijn, I., Raaijmakers, J. M., Tolker-Nielsen, Tim & Nybroe, O., 2015, In: Microbiology. 161, 12, p. 2289-2297 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      Architecture and spatial organization in a triple-species bacterial biofilm synergistically degrading the phenylurea herbicide linuron

      Breugelmans, P., Barken, K. B., Tolker-Nielsen, Tim, Hofkens, J., Dejonghe, W. & Springael, D., May 2008, In: F E M S Microbiology Ecology. 64, 2, p. 271-82 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

      Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.

      Research output: Contribution to journalReviewResearchpeer-review

    31. Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.

      Caldwell, D. E., Colwell, R. R., Harayama, S., Kjelleberg, S., Givskov, M., Molin, S., Nielsen, A. T., Heydorn, A., Tolker-Nielsen, Tim, Sternberg, C., Nealson, K., Pace, N. R., Rainey, P., Stackebrandt, E., Tindall, B. J. & Stahl, D. A., 2000, In: Environmental Microbiology. 2, 1, p. 3-10 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. z A study of electroplated silver-palladium biofouling inhibiting coating.

      Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Corrosion Engineering, Science and Technology. 43, 2, p. 142-148 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. z Bacteria inhibiting surfaces caused by the effects of silver release and/or electrical field.

      Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, p. 108–115 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

      Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Bacterial inhibiting surfaces caused by the effects of silver release and/or electrical field

      Chiang, W. C., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, 1, p. 108-115 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

      Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Silver-palladium surfaces inhibit biofilm formation

      Chiang, W., Schroll, C., Hilbert, L. R. & Tolker-Nielsen, Tim, 2009, In: Applied and Environmental Microbiology. 75, 6, p. 1674-8 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

      Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Extracellular DNA as matrix component in microbial biofilms.

      Chiang, W. & Tolker-Nielsen, Tim, 2010, Extracellular Nucleic Acids.. Kikuchi, Y. & Rykova, E. (eds.). Springer Publishing Company, p. 1-14 14 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    40. Published

      Influence of silver additions to type 316 stainless steels on bacterial inhibition, mechanical properties, and corrosion resistance.

      Chiang, W., Tseng, I., Møller, P., Rischel Hilbert, L., Tolker-Nielsen, Tim & Wu, J., 2010, In: Materials Chemistry and Physics. 119, p. 123–130 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

      Chua, S. L., Liu, Y., Yam, J. K. H., Chen, Y., Vejborg, R. M., Tan, B. G. C., Kjelleberg, S., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Nature Communications. 5, p. 1-12 13 p., 4462.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

      Chua, S. L., Sivakumar, K., Rybtke, Morten Levin, Yuan, M., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim, Cao, B., Kjelleberg, S. & Yang, L., 2015, In: Scientific Reports. 5, 13 p., 10052.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms

      Chua, S. L., Yam, J. K. H., Hao, P., Adav, S. S., Salido, M. M., Liu, Y., Givskov, Michael, Sze, S. K., Tolker-Nielsen, Tim & Yang, L., 2016, In: Nature Communications. 7, 11 p., 10750.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa

      Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

      Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa

      Chua, S. L., Liu, Y., Li, Y., Ting, H. J., Kohli, G. S., Cai, Z., Suwanchaikasem, P., Goh, K. K. K., Ng, S. P., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Oct 2017, In: Frontiers in Cellular and Infection Microbiology. 7, 8 p., 451.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

      Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.

      Research output: Contribution to journalReviewResearchpeer-review

    48. Published

      Antibiotic tolerance and resistance in biofilms.

      Ciofu, Oana & Tolker-Nielsen, Tim, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C., Jensen, P. Ø. & Høiby, N. (eds.). New York, USA: Springer Publishing Company, p. 215-230 16 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    49. Published

      Antibiotic tolerance and resistance in biofilms

      Ciofu, Oana & Tolker-Nielsen, Tim, 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    50. Published

      Tolerance and resistance of pseudomonas aeruginosabiofilms to antimicrobial agents-how P. aeruginosa Can escape antibiotics

      Ciofu, Oana & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 10, MAY, 15 p., 913.

      Research output: Contribution to journalReviewResearchpeer-review

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