Tim Tolker-Nielsen
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N
Member of:
- Published
Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction
Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Burkholderia cenocepacia h111 produces a water-insoluble exopolysaccharide in biofilm: Structural determination and molecular modelling
Bellich, B., Jou, I. A., Caterino, M., Rizzo, R., Ravenscroft, N., Fazli, M., Tolker-Nielsen, Tim, Brady, J. W. & Cescutti, P., 2020, In: International Journal of Molecular Sciences . 21, 5, 1702.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation
Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions
Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response
Rybtke, Morten Levin, Hultqvist, Louise Dahl, Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645Research output: Contribution to journal › Review › Research › peer-review
- Published
Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene, encoding a nitronate monooxygenase
Vercammen, K., Wei, Q., Charlier, D., Dötsch, A., Haüssler, S., Schulz, S., Salvi, F., Gadda, G., Spain, J., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Dingemans, J., Ye, L. & Cornelis, P., Mar 2015, In: Journal of Bacteriology. 197, 6, p. 1026-39 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α‐synuclein and modulates its effect on biofilm formation
Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, Tim, Christiansen, G. & Otzen, D. E., May 2018, In: FEBS Letters. 592, 9, p. 1484-1496 13 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
A broad range quorum sensing inhibitor working through sRNA inhibition
Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.Research output: Contribution to journal › Journal article › Research › peer-review
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.
Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M. & Tolker-Nielsen, Tim, 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genetic switch controls Pseudomonas aeruginosa surface colonization
Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mariner transposon vector adapted for mutagenesis in oral streptococci
Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A possible correlation between periodontitis and ischaemic heart disease
Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia
McCarthy, Y., Yang, L., Twomey, K. B., Sass, A., Tolker-Nielsen, Tim, Mahenthiralingam, E., Dow, J. M. & Ryan, R. P., 2010, In: Molecular Microbiology. 77, 5, p. 1220-1236 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.
Tolker-Nielsen, Tim & Boe, L., 1994, In: Journal of Bacteriology. 176, 14, p. 4306-10 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation
Okshevsky, M., Louw, M. G., Lamela, E. O., Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim & Meyer, R. L., 2018, In: MicrobiologyOpen. 7, 2, 17 p., e00552.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay
Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.Research output: Contribution to journal › Journal article › Research › peer-review
Advances in nucleic acid-based diagnostics of bacterial infections.
Barken, K. B., Haagensen, J. A. J. & Tolker-Nielsen, Tim, 2007, In: Clinica Chimica Acta. 384, 1-2, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal
Harmsen, M., Yang, L., Pamp, S. J. & Tolker-Nielsen, Tim, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 253-68 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibiotic tolerance and resistance in biofilms
Ciofu, Oana & Tolker-Nielsen, Tim, 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Antibiotic tolerance and resistance in biofilms.
Ciofu, Oana & Tolker-Nielsen, Tim, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C., Jensen, P. Ø. & Høiby, N. (eds.). New York, USA: Springer Publishing Company, p. 215-230 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1
Orlandi, V. T., Rybtke, Morten Levin, Caruso, E., Banfi, S., Tolker-Nielsen, Tim & Barbieri, P., Sep 2014, In: Biofouling. 30, 8, p. 883-91 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Architecture and spatial organization in a triple-species bacterial biofilm synergistically degrading the phenylurea herbicide linuron
Breugelmans, P., Barken, K. B., Tolker-Nielsen, Tim, Hofkens, J., Dejonghe, W. & Springael, D., May 2008, In: F E M S Microbiology Ecology. 64, 2, p. 271-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells.
Tolker-Nielsen, Tim, Christensen, A. B., Holmstrøm, K., Eberl, L., Rasmussen, T. B., Sternberg, C., Heydorn, A., Molin, S. & Givskov, M., 2000, In: Journal of Bacteriology. 182, 10, p. 2680-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacteria can form interconnected microcolonies when a self-excreted product reduces their surface motility: evidence from individual-based model simulations
Mabrouk, N., Deffuant, G., Tolker-Nielsen, Tim & Lobry, C., 2010, In: Theory in Biosciences. 129, 1, p. 1-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacteria-triggered release of antimicrobial agents
Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.Research output: Contribution to journal › Review › Research › peer-review
- Published
Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa
Ring, H. C., Bay, Lene, Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000Research output: Contribution to journal › Journal article › Research › peer-review
Bacterial inhibiting surfaces caused by the effects of silver release and/or electrical field
Chiang, W. C., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, 1, p. 108-115 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Biased 16S rDNA PCR amplification caused by interference from DNA flanking the template region.
Hansen, M. C., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 1998, In: FEMS Microbiology Ecology. 26, p. 141-149 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm Development
Tolker-Nielsen, Tim, Mar 2015, In: Microbiology Spectrum. 3, 2, 12 p., MB-0001-2014.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm development
Tolker-Nielsen, Tim, 2015, Microbial biofilms. Ghannoum, M., Parsek, M., Whiteley, M. & P. M. (eds.). 2 ed. Washington DC: ASM Press, p. 51-66 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Biofilm development
Tolker-Nielsen, Tim, 1 Jan 2015, Microbial Biofilms. Wiley-Interscience, p. 51-66 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Biofilm development by pseudomonads.
Tolker-Nielsen, Tim & Molin, S., 2004, Environmental Biotechnology. Verstraete, W. (ed.). CRC Press/Balkema, p. 27-32Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants.
Klausen, M., Heydorn, A., Ragas, P., Lambertsen, L., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 48, 6, p. 1511-24 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa
Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilms can act as plasmid reserves in the absence of plasmid specific selection
Røder, Henriette Lyng, Trivedi, Urvish, Russel, J., Kragh, K. N., Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: npj Biofilms and Microbiomes. 7, 6 p., 78.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions
Schwarz, S., West, T. E., Boyer, F., Chiang, W., Carl, M. A., Hood, R. D., Rohmer, L., Tolker-Nielsen, Tim, Skerrett, S. J. & Mougous, J. D., 2010, In: PLoS Pathogens. 6, 8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bursting the bubble on bacterial biofilms: a flow cell methodology
Crusz, S. A., Popat, R., Rybtke, Morten Levin, Cámara, M., Givskov, Michael, Tolker-Nielsen, Tim, Diggle, S. P. & Williams, P., 2012, In: Biofouling. 28, 8, p. 835-842 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Chua, S. L., Sivakumar, K., Rybtke, Morten Levin, Yuan, M., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim, Cao, B., Kjelleberg, S. & Yang, L., 2015, In: Scientific Reports. 5, 13 p., 10052.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa
Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CDy14: A novel biofilm probe targeting exopolysaccharide Psl
Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.Research output: Contribution to journal › Journal article › Research › peer-review
Cell death in Pseudomonas aeruginosa biofilm development.
Webb, J. S., Thompson, L. S., James, S., Charlton, T., Tolker-Nielsen, Tim, Koch, B., Givskov, M. & Kjelleberg, S., 2003, In: Journal of Bacteriology. 185, 15, p. 4585-92 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Challenges in using transcriptome data to study the c-di-GMP signaling network in Pseudomonas aeruginosa clinical isolates
Gür, M., Erdmann, J., Will, A., Liang, Z., Andersen, Jens Bo, Tolker-Nielsen, Tim & Häussler, S., 2023, In: FEMS Microbes. 4, 10 p., xtad012.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark
Nielsen, K. L., Hammerum, A. M., Lambertsen, L. M., Lester, C. H., Arpi, M., Knudsen, J. D., Stegger, M., Tolker-Nielsen, Tim & Frimodt-Møller, N., 2010, In: Scandinavian Journal of Infectious Diseases. 42, 8, p. 586-93 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6.
Hansen, S. K., Haagensen, J. A. J., Gjermansen, M., Jørgensen, T. M., Tolker-Nielsen, Tim & Molin, S., 2007, In: Journal of Bacteriology. 189, 13, p. 4932-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Characterization of starvation-induced dispersion in Pseudomonas putida biofilms.
Gjermansen, M., Ragas, P., Sternberg, C., Molin, S. & Tolker-Nielsen, Tim, 2005, In: Environmental Microbiology. 7, 6, p. 894-906 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms
Gjermansen, M., Nilsson, Carl Martin Peter, Yang, L. & Tolker-Nielsen, Tim, 2010, In: Molecular Microbiology. 75, 4, p. 815-26 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8656938
Most downloads
-
1316
downloads
Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
801
downloads
C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
324
downloads
Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Research output: Contribution to journal › Review › Research › peer-review
Published