Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

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    ORCID: 0000-0002-9751-474X

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    1. Published

      Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

      Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    2. Published

      Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

      Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Cloning and characterization of two plasmids from Bacillus thuringiensis in Bacillus subtilis.

      Boe, L., Tolker-Nielsen, Tim, Madsen, S. M., Andrup, L. & Bolander, G., 1991, In: Plasmid. 25, 3, p. 190-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

      Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials

      Gulez, G., Altintas, A., Fazli, M., Dechesne, A., Workman, C., Tolker-Nielsen, Tim & Smets, B. F., 2014, In: MicrobiologyOpen. 3, 4, p. 457-469

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

      Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

      Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

      Sun, J., Marais, J. P. J., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, Michael, Tolker-Nielsen, Tim, Seeram, N. P. & Rowley, D. C., Aug 2015, In: Journal of Functional Foods. 17, p. 235-242 8 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    9. Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.

      Caldwell, D. E., Colwell, R. R., Harayama, S., Kjelleberg, S., Givskov, M., Molin, S., Nielsen, A. T., Heydorn, A., Tolker-Nielsen, Tim, Sternberg, C., Nealson, K., Pace, N. R., Rainey, P., Stackebrandt, E., Tindall, B. J. & Stahl, D. A., 2000, In: Environmental Microbiology. 2, 1, p. 3-10 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity

      Hoong Yam, J. K., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Santillan Salido, M. M., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Wu, B., Kjelleberg, S., Tolker-Nielsen, Tim, Beuerman, R. W., Givskov, Michael & Yang, L., 2017, bioRxiv, 35 p.

      Research output: Working paper › Preprint › Research

    11. Published

      Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa

      Lichtenberg, Mads, Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2022, In: Cell Reports. 41, 3, p. 111515 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.

      Eckhart, L., Fischer, H., Barken, K. B., Tolker-Nielsen, Tim & Tschachler, E., 2007, In: British Journal of Dermatology. 156, 6, p. 1342-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Development and dynamics of Pseudomonas sp. biofilms.

      Tolker-Nielsen, Tim, Brinch, U. C., Ragas, P. C., Andersen, J. B., Jacobsen, C. S. & Molin, S., 2000, In: Journal of Bacteriology. 182, 22, p. 6482-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.

      Haagensen, J. A. J., Klausen, M., Ernst, R. K., Miller, S. I., Folkesson, A., Tolker-Nielsen, Tim & Molin, S., 2006, In: Journal of Bacteriology. 189, 1, p. 28-37 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

      Chua, S. L., Liu, Y., Yam, J. K. H., Chen, Y., Vejborg, R. M., Tan, B. G. C., Kjelleberg, S., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Nature Communications. 5, p. 1-12 13 p., 4462.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit

      Soh, E., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Camara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, bioRxiv, 43 p.

      Research output: Working paper › Preprint › Research

    18. Published

      Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit

      Soh, E. Y. C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Cámara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, In: PLOS Pathogens. 17, 8, 25 p., e1009425.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Distribution, organization, and ecology of bacteria in chronic wounds

      Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, M., Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82

      Tay, M., Roizman, D., Cohen, Y., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Genome Announcements. 2, 1, p. 1 1 p., e01161-13.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms.

      Klausen, M., Gjermansen, M., Kreft, J. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 261, 1, p. 1-11 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo

      Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, Morten Levin, Seliktar, D., Kofidis, T., Høiby, Niels, Tolker-Nielsen, Tim, Song, Z. & Givskov, Michael, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

      Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.

      Yang, L., Barken, K. B., Skindersoe, M. E., Christensen, A. B., Givskov, M. & Tolker-Nielsen, Tim, 2007, In: Microbiology. 153, Pt 5, p. 1318-28 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Effects of stress treatments on the detection of Salmonella typhimurium by in situ hybridization.

      Tolker-Nielsen, Tim, Larsen, M. H., Kyed, H. & Molin, S., 1997, In: International Journal of Food Microbiology. 35, 3, p. 251-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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