Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

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    ORCID: 0000-0002-9751-474X

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    1. Published

      Inoculation method could impact the outcome of microbiological experiments

      Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

      Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    3. Published

      Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

      Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

      Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      CDy14: A novel biofilm probe targeting exopolysaccharide Psl

      Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells.

      Lange, M., Tolker-Nielsen, Tim, Molin, S. & Ahring, B. K., 2000, In: Applied and Environmental Microbiology. 66, 5, p. 1796-800 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa.

      Li, Y., Xia, H., Bai, F., Xu, H., Yang, L., Yao, H., Zhang, L., Zhang, X., Bai, Y., Saris, P. E. J., Tolker-Nielsen, Tim & Qiao, M., 2007, In: FEMS Microbiology Letters. 272, 2, p. 188-95 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP

      Liang, Z., Rybtke, Morten Levin, Kragh, K. N., Johnson, O., Schicketanz, Muriel Leandra, Zhang, Yong, Andersen, Jens Bo & Tolker-Nielsen, Tim, 2022, In: Microbiology Spectrum. 10, 4, 13 p., e00675-22.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The role of individual exopolysaccharides in antibiotic tolerance of Pseudomonas aeruginosa aggregates

      Liang, Z., Nilsson, M., Kragh, K. N., Hedal, I., Alcàcer-Almansa, J., Kiilerich, R. O., Andersen, Jens Bo & Tolker-Nielsen, Tim, 2023, In: Frontiers in Microbiology. 14, 1187708.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.

      Licht, T. R., Tolker-Nielsen, Tim, Holmstrøm, K., Krogfelt, K. & Molin, S., 1999, In: Environmental Microbiology. 1, 1, p. 23-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa

      Lichtenberg, Mads, Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2022, In: Cell Reports. 41, 3, p. 111515 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa

      Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Redox protein osar (pa0056) regulates dsbm and the oxidative stress response in pseudomonas aeruginosa

      Liu, Y., Ma, Y., Ma, Z., Han, X., Qi, H., Andersen, Jens Bo, Xu, H., Tolker-Nielsen, Tim & Qiao, M., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 3, e01771-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Bacteria can form interconnected microcolonies when a self-excreted product reduces their surface motility: evidence from individual-based model simulations

      Mabrouk, N., Deffuant, G., Tolker-Nielsen, Tim & Lobry, C., 2010, In: Theory in Biosciences. 129, 1, p. 1-13 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      A genetic switch controls Pseudomonas aeruginosa surface colonization

      Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia

      McCarthy, Y., Yang, L., Twomey, K. B., Sass, A., Tolker-Nielsen, Tim, Mahenthiralingam, E., Dow, J. M. & Ryan, R. P., 2010, In: Molecular Microbiology. 77, 5, p. 1220-1236 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Pseudomonas aeruginosa: A Model for Biofilm Formation

      McDougald, D., Klebensberger, J., Tolker-Nielsen, Tim, Webb, J. S., Conibear, T., Rice, S. A., Kirov, S. M., Matz, C. & Kjelleberg, S., 2008,   Pseudomonas. Model Organism, Pathogen, Cell Factory.. Rehm, B. H. A. (ed.). Wiley-VCH, p. 215-254 40 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    18. Published

      In silico analyses of metagenomes from human atherosclerotic plaque samples

      Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure.

      Molin, S. & Tolker-Nielsen, Tim, 2003, In: Current Opinion in Biotechnology. 14, 3, p. 255-61 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Molecular ecology of biofilms.

      Molin, S., Nielsen, A. T., Christensen, B. B., Andersen, J. B., Licht, T. R., Tolker-Nielsen, Tim, Sternberg, C., Hansen, M. C., Ramos, C. & Givskov, M., 2000, Biofilms.. Wiley, p. 89-120

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    21. Microbial interactions in mixed-species biofilms.

      Molin, S., Tolker-Nielsen, Tim & Hansen, S. K., 2004, Microbial biofilms.. Ghannoum, M. & O’Toole, G. A. (eds.). ASM International, p. 206-221

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    22. Published

      Immune Responses to Pseudomonas aeruginosa Biofilm Infections

      Moser, Claus Ernst, Jensen, Peter Østrup, Thomsen, K., Kolpen, M., Rybtke, Morten Levin, Lauland, A. S., Trøstrup, H. & Tolker-Nielsen, Tim, 2021, In: Frontiers in Immunology. 12, 625597.

      Research output: Contribution to journal › Review › Research › peer-review

    23. Published

      Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

      Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Role of commensal relationships on the spatial structure of a surface-attached microbial consortium.

      Nielsen, A. T., Tolker-Nielsen, Tim, Barken, K. B. & Molin, S., 2000, In: Environmental Microbiology. 2, 1, p. 59-68 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark

      Nielsen, K. L., Hammerum, A. M., Lambertsen, L. M., Lester, C. H., Arpi, M., Knudsen, J. D., Stegger, M., Tolker-Nielsen, Tim & Frimodt-Møller, N., 2010, In: Scandinavian Journal of Infectious Diseases. 42, 8, p. 586-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In: International Journal of Antimicrobial Agents. 48, 3, p. 298–304

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

      Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

      Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      A mariner transposon vector adapted for mutagenesis in oral streptococci

      Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Transposon Mutagenesis in Streptococcus Species

      Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, 2019, Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, p. 39-49 11 p. (Methods in Molecular Biology, Vol. 2016).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    32. Published

      A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation

      Okshevsky, M., Louw, M. G., Lamela, E. O., Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim & Meyer, R. L., 2018, In: MicrobiologyOpen. 7, 2, 17 p., e00552.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress

      Orlandi, V. T., Bolognese, F., Chiodaroli, L., Tolker-Nielsen, Tim & Barbieri, P., Dec 2015, In: Microbiology. 161, 12, p. 2298-309 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1

      Orlandi, V. T., Rybtke, Morten Levin, Caruso, E., Banfi, S., Tolker-Nielsen, Tim & Barbieri, P., Sep 2014, In: Biofouling. 30, 8, p. 883-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. The biofilm matrix - A sticky framework.

      Pamp, S., Gjermansen, M. & Tolker-Nielsen, Tim, 2007, The biofilm mode of life - Mechanisms and adaptations.. Kjelleberg, S. & Givskov, M. (eds.). HorizonBioscience, p. 37-69

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    36. Published

      Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

      Pamp, S. J., Gjermansen, M., Johansen, Helle Krogh & Tolker-Nielsen, Tim, 2008, In: Molecular Microbiology. 68, 1, p. 223-40 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.

      Pamp, S. J. & Tolker-Nielsen, Tim, 2007, In: Journal of Bacteriology. 189, 6, p. 2531-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy

      Pamp, S. J., Sternberg, C. & Tolker-Nielsen, Tim, 2009, In: Cytometry. Part A. 75, 2, p. 90-103 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Pattern formation in Pseudomonas aeruginosa biofilms.

      Parsek, M. R. & Tolker-Nielsen, Tim, 2008, In: Current Opinion in Microbiology. 11, p. 560-566 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Microbial motility involvement in biofilm structure formation--a 3D modelling study.

      Picioreanu, C., Kreft, J. U., Klausen, M., Haagensen, J. A. J., Tolker-Nielsen, Tim & Molin, S., 2007, In: Water Science and Technology. 55, 8-9, p. 337-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa

      Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis

      Qin, Z., Yang, L., Qu, D., Molin, S. & Tolker-Nielsen, Tim, 2009, In: Microbiology. 155, Pt 7, p. 2148-56 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.

      Qin, Z., Ou, Y., Yang, L., Zhu, Y., Tolker-Nielsen, Tim, Molin, S. & Qu, D., 2007, In: Microbiology. 153, Pt 7, p. 2083-92 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

      Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

      Research output: Contribution to journal › Review › Research › peer-review

    45. Microbial pathogenesis and biofilm development.

      Reisner, A., Høiby, N., Tolker-Nielsen, Tim & Molin, S., 2005, In: Contributions to Microbiology. 12, p. 114-31 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

      Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa

      Ring, H. C., Bay, Lene, Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.

      Ryan, R. P., Fouhy, Y., Garcia, B. F., Watt, S. A., Niehaus, K., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2008, In: Molecular Microbiology. 68, 1, p. 75-86 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      When the PilZ don't work: effectors for cyclic di-GMP action in bacteria

      Ryan, R. P., Tolker-Nielsen, Tim & Dow, J. M., May 2012, In: Current Trends in Microbiology. 20, 5, p. 235-242 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa

      Ryan, R. P., Lucey, J., O'Donovan, K., McCarthy, Y., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2009, In: Environmental Microbiology. 11, 5, p. 1126-36 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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