Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

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    ORCID: 0000-0002-9751-474X

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    1. Published

      Importance of the exopolysaccharide matrix in antimicrobial tolerance of Pseudomonas aeruginosa aggregates

      Goltermann, Lise & Tolker-Nielsen, Tim, Apr 2017, In: Antimicrobial Agents and Chemotherapy. 61, 4, 7 p., e02696.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      In silico analyses of metagenomes from human atherosclerotic plaque samples

      Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells.

      Lange, M., Tolker-Nielsen, Tim, Molin, S. & Ahring, B. K., 2000, In: Applied and Environmental Microbiology. 66, 5, p. 1796-800 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      In-frame and unmarked gene deletions in Burkholderia cenocepacia via an allelic exchange system compatible with gateway technology

      Fazli, M., Harrison, J. J., Gambino, M., Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Applied and Environmental Microbiology. 81, 11, p. 3623-3630 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

      Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

      Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

      Teh, W. K., Dramsi, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

      Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Influence of silver additions to type 316 stainless steels on bacterial inhibition, mechanical properties, and corrosion resistance.

      Chiang, W., Tseng, I., Møller, P., Rischel Hilbert, L., Tolker-Nielsen, Tim & Wu, J., 2010, In: Materials Chemistry and Physics. 119, p. 123–130 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

      Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.

      Licht, T. R., Tolker-Nielsen, Tim, Holmstrøm, K., Krogfelt, K. & Molin, S., 1999, In: Environmental Microbiology. 1, 1, p. 23-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Inoculation method could impact the outcome of microbiological experiments

      Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy

      Pamp, S. J., Sternberg, C. & Tolker-Nielsen, Tim, 2009, In: Cytometry. Part A. 75, 2, p. 90-103 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Interfering with bacterial gossip.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    17. Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.

      Ryan, R. P., Fouhy, Y., Garcia, B. F., Watt, S. A., Niehaus, K., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2008, In: Molecular Microbiology. 68, 1, p. 75-86 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms.

      Klausen, M., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 50, 1, p. 61-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

      Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms

      Bonnichsen, L., Svenningsen, N. B., Rybtke, Morten Levin, de Bruijn, I., Raaijmakers, J. M., Tolker-Nielsen, Tim & Nybroe, O., 2015, In: Microbiology. 161, 12, p. 2289-2297 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Methods for studying biofilm formation: flow cells and confocal laser scanning microscopy

      Tolker-Nielsen, Tim & Sternberg, C., 2014, In: Methods in Molecular Biology. 1149, p. 615-29 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Microbial interactions in mixed-species biofilms.

      Molin, S., Tolker-Nielsen, Tim & Hansen, S. K., 2004, Microbial biofilms.. Ghannoum, M. & O’Toole, G. A. (eds.). ASM International, p. 206-221

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    23. Microbial motility involvement in biofilm structure formation--a 3D modelling study.

      Picioreanu, C., Kreft, J. U., Klausen, M., Haagensen, J. A. J., Tolker-Nielsen, Tim & Molin, S., 2007, In: Water Science and Technology. 55, 8-9, p. 337-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Microbial pathogenesis and biofilm development.

      Reisner, A., Høiby, N., Tolker-Nielsen, Tim & Molin, S., 2005, In: Contributions to Microbiology. 12, p. 114-31 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Molecular ecology of biofilms.

      Molin, S., Nielsen, A. T., Christensen, B. B., Andersen, J. B., Licht, T. R., Tolker-Nielsen, Tim, Sternberg, C., Hansen, M. C., Ramos, C. & Givskov, M., 2000, Biofilms.. Wiley, p. 89-120

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    26. Published

      Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

      Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.

      Pamp, S. J. & Tolker-Nielsen, Tim, 2007, In: Journal of Bacteriology. 189, 6, p. 2531-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa

      Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Non-genetic population heterogeneity studied by in situ polymerase chain reaction.

      Tolker-Nielsen, Tim, Holmstrøm, K., Boe, L. & Molin, S., 1998, In: Molecular Microbiology. 27, 6, p. 1099-105 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, B., Andersen, A. S., Krogfelt, K. A., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Journal of Clinical Microbiology. 47, 12, p. 4084-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

      Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa

      Yang, L., Liu, Y., Markussen, T., Høiby, Niels, Tolker-Nielsen, Tim & Molin, S., 1 Aug 2011, In: F E M S Immunology and Medical Microbiology. 62, 3, p. 339-47 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Pattern formation in Pseudomonas aeruginosa biofilms.

      Parsek, M. R. & Tolker-Nielsen, Tim, 2008, In: Current Opinion in Microbiology. 11, p. 560-566 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Physiological states of individual Salmonella typhimurium cells monitored by in situ reverse transcription-PCR.

      Hølmstrom, K., Tolker-Nielsen, Tim & Molin, S., 1999, In: Journal of Bacteriology. 181, 6, p. 1733-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress

      Orlandi, V. T., Bolognese, F., Chiodaroli, L., Tolker-Nielsen, Tim & Barbieri, P., Dec 2015, In: Microbiology. 161, 12, p. 2298-309 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Plasmid stability: comments on the dimer catastrophe hypothesis.

      Boe, L. & Tolker-Nielsen, Tim, 1997, In: Molecular Microbiology. 23, 2, p. 247-53 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

      Hmelo, L. R., Borlee, B. R., Almblad, H., Love, M. E., Randall, T. E., Tseng, B. S., Lin, C., Irie, Y., Storek, K. M., Yang, J. J., Siehnel, R. J., Howell, P. L., Singh, P. K., Tolker-Nielsen, Tim, Parsek, M. R., Schweizer, H. P. & Harrison, J. J., Nov 2015, In: Nature Protocols (Print). 10, 11, p. 1820-41 22 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal.

      Gjermansen, M., Ragas, P. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 265, 2, p. 215-24 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry

      Beilharz, K., Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim, Bjarnsholt, Thomas & Lichtenberg, Mads, 2023, In: STAR Protocols. 4, 2, 102269.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Pseudomonas aeruginosa biofilm infections: From molecular biofilm biology to new treatment possibilities

      Tolker-Nielsen, Tim, Dec 2014, 51 p. (APMIS Supplementum).

      Research output: Book/Report › Doctoral thesis › Research

    44. Published

      Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis

      Qin, Z., Yang, L., Qu, D., Molin, S. & Tolker-Nielsen, Tim, 2009, In: Microbiology. 155, Pt 7, p. 2148-56 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.

      Whitchurch, C. B., Beatson, S. A., Comolli, J. C., Jakobsen, T., Sargent, J. L., Bertrand, J. J., West, J., Klausen, M., Waite, L. L., Kang, P. J., Tolker-Nielsen, Tim, Mattick, J. S. & Engel, J. N., 2005, In: Molecular Microbiology. 55, 5, p. 1357-78 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Pseudomonas aeruginosa: A Model for Biofilm Formation

      McDougald, D., Klebensberger, J., Tolker-Nielsen, Tim, Webb, J. S., Conibear, T., Rice, S. A., Kirov, S. M., Matz, C. & Kjelleberg, S., 2008,   Pseudomonas. Model Organism, Pathogen, Cell Factory.. Rehm, B. H. A. (ed.). Wiley-VCH, p. 215-254 40 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    47. Published

      Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

      Yang, L., Nilsson, Carl Martin Peter, Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Molecular Microbiology. 74, 6, p. 1380-92 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, A., Andersen, C. B., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Wound Repair and Regeneration. 19, 3, p. 387-91 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Quorum sensing inhibitors disable bacterial biofilms.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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