Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

Research output: Contribution to journalJournal articleResearchpeer-review

Escherichia coli is a versatile pathogen causing millions of infections in humans every year. This bacterium can form multicellular aggregates when it expresses a self-associating protein, antigen 43 (Ag43), on its surface. We have discovered that Ag43-expressing E. coli cells are efficiently taken up by human defense cells, polymorphonuclear neutrophils (PMNs), in an opsonin-independent manner. Surprisingly, the phagocytosed bacteria were not immediately killed but resided as tight aggregates within the PMNs. Our observations indicate that Ag43-mediated uptake and survival in PMNs constitute a mechanism to subvert one of the primary defense mechanisms of the human body.
Original languageEnglish
JournalInfection and Immunity
Issue number1
Pages (from-to)30-4
Number of pages4
Publication statusPublished - 2006

Bibliographical note

Keywords: Adhesins, Bacterial; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Cells, Cultured; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Humans; Neutrophils; Phagocytosis

ID: 10613916