Chemical biology strategies for biofilm control
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Chemical biology strategies for biofilm control. / Yang, Liang; Givskov, Michael.
Microbial Biofilms. Wiley-Interscience, 2015. p. 363-372.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Chemical biology strategies for biofilm control
AU - Yang, Liang
AU - Givskov, Michael
N1 - Publisher Copyright: © 2015 by ASM Press.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Signaling pathways are required for bacterial biofilm formation and antimicrobial resistance. Among them, quorum sensing (QS) and c-di-GMP signaling are the best characterized. QS is a widely distributed intercellular signaling mechanism by which microorganisms regulate gene expression in response to small diffusible signaling molecules (1). Bacteria have developed oligopeptides, N-acyl homoserine lactones (HSLs), and autoinducer-2 as signal molecules (1). When the QS signal molecules reach a local threshold concentration, they can interact with specific receptors and impact the expression of hundreds of genes. Many of the QS-regulated genes (motility, biosurfacant synthesis, EPS synthesis) are required for the biofilm formation and antibiotic resistance of various bacterial species (2).
AB - Signaling pathways are required for bacterial biofilm formation and antimicrobial resistance. Among them, quorum sensing (QS) and c-di-GMP signaling are the best characterized. QS is a widely distributed intercellular signaling mechanism by which microorganisms regulate gene expression in response to small diffusible signaling molecules (1). Bacteria have developed oligopeptides, N-acyl homoserine lactones (HSLs), and autoinducer-2 as signal molecules (1). When the QS signal molecules reach a local threshold concentration, they can interact with specific receptors and impact the expression of hundreds of genes. Many of the QS-regulated genes (motility, biosurfacant synthesis, EPS synthesis) are required for the biofilm formation and antibiotic resistance of various bacterial species (2).
KW - Biofilm control
KW - Chemical biology strategy
KW - Cyclic di-GMP
KW - Diguanylate cyclase
KW - Quorum sensing
KW - SRNAs
U2 - 10.1128/9781555817466.ch18
DO - 10.1128/9781555817466.ch18
M3 - Book chapter
AN - SCOPUS:85140942593
SN - 9781555817459
SP - 363
EP - 372
BT - Microbial Biofilms
PB - Wiley-Interscience
ER -
ID: 340025918