Chemical biology strategies for biofilm control
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Signaling pathways are required for bacterial biofilm formation and antimicrobial resistance. Among them, quorum sensing (QS) and c-di-GMP signaling are the best characterized. QS is a widely distributed intercellular signaling mechanism by which microorganisms regulate gene expression in response to small diffusible signaling molecules (1). Bacteria have developed oligopeptides, N-acyl homoserine lactones (HSLs), and autoinducer-2 as signal molecules (1). When the QS signal molecules reach a local threshold concentration, they can interact with specific receptors and impact the expression of hundreds of genes. Many of the QS-regulated genes (motility, biosurfacant synthesis, EPS synthesis) are required for the biofilm formation and antibiotic resistance of various bacterial species (2).
Original language | English |
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Title of host publication | Microbial Biofilms |
Number of pages | 10 |
Publisher | Wiley-Interscience |
Publication date | 1 Jan 2015 |
Pages | 363-372 |
Chapter | 18 |
ISBN (Print) | 9781555817459 |
ISBN (Electronic) | 9781683670919 |
DOIs | |
Publication status | Published - 1 Jan 2015 |
Bibliographical note
Publisher Copyright:
© 2015 by ASM Press.
- Biofilm control, Chemical biology strategy, Cyclic di-GMP, Diguanylate cyclase, Quorum sensing, SRNAs
Research areas
ID: 340025918