Expedient total synthesis of pyrrothine natural products and analogs

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Expedient total synthesis of pyrrothine natural products and analogs. / Hjelmgaard, Thomas; Givskov, Michael; Nielsen, John.

In: Organic & Biomolecular Chemistry, Vol. 5, No. 2, 2006, p. 344-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hjelmgaard, T, Givskov, M & Nielsen, J 2006, 'Expedient total synthesis of pyrrothine natural products and analogs', Organic & Biomolecular Chemistry, vol. 5, no. 2, pp. 344-8. https://doi.org/10.1039/b616411k

APA

Hjelmgaard, T., Givskov, M., & Nielsen, J. (2006). Expedient total synthesis of pyrrothine natural products and analogs. Organic & Biomolecular Chemistry, 5(2), 344-8. https://doi.org/10.1039/b616411k

Vancouver

Hjelmgaard T, Givskov M, Nielsen J. Expedient total synthesis of pyrrothine natural products and analogs. Organic & Biomolecular Chemistry. 2006;5(2):344-8. https://doi.org/10.1039/b616411k

Author

Hjelmgaard, Thomas ; Givskov, Michael ; Nielsen, John. / Expedient total synthesis of pyrrothine natural products and analogs. In: Organic & Biomolecular Chemistry. 2006 ; Vol. 5, No. 2. pp. 344-8.

Bibtex

@article{acb730e0fce511ddb219000ea68e967b,
title = "Expedient total synthesis of pyrrothine natural products and analogs",
abstract = "This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of , and (7 steps, 11-12% overall).",
author = "Thomas Hjelmgaard and Michael Givskov and John Nielsen",
note = "Keywords: Anti-Bacterial Agents; Chemistry, Organic; Chromatography, Thin Layer; DNA-Directed RNA Polymerases; Lactams; Models, Chemical; Pseudomonas; RNA, Bacterial; Streptomyces; Xenorhabdus",
year = "2006",
doi = "10.1039/b616411k",
language = "English",
volume = "5",
pages = "344--8",
journal = "Organic & Biomolecular Chemistry",
issn = "1470-4358",
publisher = "Royal Society of Chemistry",
number = "2",

}

RIS

TY - JOUR

T1 - Expedient total synthesis of pyrrothine natural products and analogs

AU - Hjelmgaard, Thomas

AU - Givskov, Michael

AU - Nielsen, John

N1 - Keywords: Anti-Bacterial Agents; Chemistry, Organic; Chromatography, Thin Layer; DNA-Directed RNA Polymerases; Lactams; Models, Chemical; Pseudomonas; RNA, Bacterial; Streptomyces; Xenorhabdus

PY - 2006

Y1 - 2006

N2 - This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of , and (7 steps, 11-12% overall).

AB - This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of , and (7 steps, 11-12% overall).

U2 - 10.1039/b616411k

DO - 10.1039/b616411k

M3 - Journal article

C2 - 17205179

VL - 5

SP - 344

EP - 348

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

SN - 1470-4358

IS - 2

ER -

ID: 10613700