Expedient total synthesis of pyrrothine natural products and analogs
Research output: Contribution to journal › Journal article › Research › peer-review
This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of , and (7 steps, 11-12% overall).
Original language | English |
---|---|
Journal | Organic & Biomolecular Chemistry |
Volume | 5 |
Issue number | 2 |
Pages (from-to) | 344-8 |
Number of pages | 4 |
ISSN | 1477-0520 |
DOIs | |
Publication status | Published - 2006 |
Externally published | Yes |
Bibliographical note
Keywords: Anti-Bacterial Agents; Chemistry, Organic; Chromatography, Thin Layer; DNA-Directed RNA Polymerases; Lactams; Models, Chemical; Pseudomonas; RNA, Bacterial; Streptomyces; Xenorhabdus
ID: 10613700