Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections. / Jensen, Peter Østrup; Møller, Signe Agnete; Stjernekilde, Simone; Olsen, Pernille; Moser, Claus; Schwartz, Franziska Angelika; Lerche, Christian Johann; Høiby, Niels; Hyldegaard, Ole; Faurholt-jepsen, Daniel; Kolpen, Mette.

Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, 2022. p. 201-223 (Antibiofilm Strategies, Vol. 11).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Jensen, PØ, Møller, SA, Stjernekilde, S, Olsen, P, Moser, C, Schwartz, FA, Lerche, CJ, Høiby, N, Hyldegaard, O, Faurholt-jepsen, D & Kolpen, M 2022, Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections. in Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, Antibiofilm Strategies, vol. 11, pp. 201-223. https://doi.org/10.1007/978-3-031-10992-8_9

APA

Jensen, P. Ø., Møller, S. A., Stjernekilde, S., Olsen, P., Moser, C., Schwartz, F. A., Lerche, C. J., Høiby, N., Hyldegaard, O., Faurholt-jepsen, D., & Kolpen, M. (2022). Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections. In Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms (pp. 201-223). Springer. Antibiofilm Strategies Vol. 11 https://doi.org/10.1007/978-3-031-10992-8_9

Vancouver

Jensen PØ, Møller SA, Stjernekilde S, Olsen P, Moser C, Schwartz FA et al. Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections. In Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer. 2022. p. 201-223. (Antibiofilm Strategies, Vol. 11). https://doi.org/10.1007/978-3-031-10992-8_9

Author

Jensen, Peter Østrup ; Møller, Signe Agnete ; Stjernekilde, Simone ; Olsen, Pernille ; Moser, Claus ; Schwartz, Franziska Angelika ; Lerche, Christian Johann ; Høiby, Niels ; Hyldegaard, Ole ; Faurholt-jepsen, Daniel ; Kolpen, Mette. / Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections. Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, 2022. pp. 201-223 (Antibiofilm Strategies, Vol. 11).

Bibtex

@inbook{b766a8c19e1847268f9a9e47d06e7ed4,
title = "Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections",
abstract = "The failing eradication of bacterial biofilm by antibiotic treatment is a major clinical challenge for patients with chronic infections. The effect of re-sensitizing infectious biofilms to antibiotics by supplemental O2 has recently been explained by the pathophysiological conditions of the infectious microenvironment. In this chapter, we argue that multifactorial restrictions of O2, caused by O2 depletion within the infectious microenvironment, determine the tolerance of bacterial phenotypes ranging from the endogenous formation of persistent subpopulations within biofilms to the induction of tolerant biofilm by the host response. Consequently, we describe how reoxygenation may re-sensitize microorganisms growing in biofilms to antibiotics. To further emphasize the importance of O2 distribution we demonstrate the significance of O2 availability for the outcome of susceptibility testing.",
author = "Jensen, {Peter {\O}strup} and M{\o}ller, {Signe Agnete} and Simone Stjernekilde and Pernille Olsen and Claus Moser and Schwartz, {Franziska Angelika} and Lerche, {Christian Johann} and Niels H{\o}iby and Ole Hyldegaard and Daniel Faurholt-jepsen and Mette Kolpen",
year = "2022",
doi = "10.1007/978-3-031-10992-8_9",
language = "English",
isbn = "978-3-031-10994-2",
series = "Antibiofilm Strategies",
pages = "201--223",
booktitle = "Antibiofilm Strategies",
publisher = "Springer",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections

AU - Jensen, Peter Østrup

AU - Møller, Signe Agnete

AU - Stjernekilde, Simone

AU - Olsen, Pernille

AU - Moser, Claus

AU - Schwartz, Franziska Angelika

AU - Lerche, Christian Johann

AU - Høiby, Niels

AU - Hyldegaard, Ole

AU - Faurholt-jepsen, Daniel

AU - Kolpen, Mette

PY - 2022

Y1 - 2022

N2 - The failing eradication of bacterial biofilm by antibiotic treatment is a major clinical challenge for patients with chronic infections. The effect of re-sensitizing infectious biofilms to antibiotics by supplemental O2 has recently been explained by the pathophysiological conditions of the infectious microenvironment. In this chapter, we argue that multifactorial restrictions of O2, caused by O2 depletion within the infectious microenvironment, determine the tolerance of bacterial phenotypes ranging from the endogenous formation of persistent subpopulations within biofilms to the induction of tolerant biofilm by the host response. Consequently, we describe how reoxygenation may re-sensitize microorganisms growing in biofilms to antibiotics. To further emphasize the importance of O2 distribution we demonstrate the significance of O2 availability for the outcome of susceptibility testing.

AB - The failing eradication of bacterial biofilm by antibiotic treatment is a major clinical challenge for patients with chronic infections. The effect of re-sensitizing infectious biofilms to antibiotics by supplemental O2 has recently been explained by the pathophysiological conditions of the infectious microenvironment. In this chapter, we argue that multifactorial restrictions of O2, caused by O2 depletion within the infectious microenvironment, determine the tolerance of bacterial phenotypes ranging from the endogenous formation of persistent subpopulations within biofilms to the induction of tolerant biofilm by the host response. Consequently, we describe how reoxygenation may re-sensitize microorganisms growing in biofilms to antibiotics. To further emphasize the importance of O2 distribution we demonstrate the significance of O2 availability for the outcome of susceptibility testing.

U2 - 10.1007/978-3-031-10992-8_9

DO - 10.1007/978-3-031-10992-8_9

M3 - Book chapter

SN - 978-3-031-10994-2

T3 - Antibiofilm Strategies

SP - 201

EP - 223

BT - Antibiofilm Strategies

PB - Springer

ER -

ID: 345055584