In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy. / Roizman, Dan; Vidaillac, Celine; Givskov, Michael; Yang, Liang.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 10, e01088-17, 2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Roizman, D, Vidaillac, C, Givskov, M & Yang, L 2017, 'In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy', Antimicrobial Agents and Chemotherapy, vol. 61, no. 10, e01088-17. https://doi.org/10.1128/AAC.01088-17

APA

Roizman, D., Vidaillac, C., Givskov, M., & Yang, L. (2017). In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy. Antimicrobial Agents and Chemotherapy, 61(10), [e01088-17]. https://doi.org/10.1128/AAC.01088-17

Vancouver

Roizman D, Vidaillac C, Givskov M, Yang L. In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy. Antimicrobial Agents and Chemotherapy. 2017;61(10). e01088-17. https://doi.org/10.1128/AAC.01088-17

Author

Roizman, Dan ; Vidaillac, Celine ; Givskov, Michael ; Yang, Liang. / In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy. In: Antimicrobial Agents and Chemotherapy. 2017 ; Vol. 61, No. 10.

Bibtex

@article{517de6f93a2d4f03828c0d53b2c2b464,
title = "In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy",
abstract = "As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.",
keywords = "antibiotic resistance, biofilms, cyclic di-GMP, dispersal, synergism",
author = "Dan Roizman and Celine Vidaillac and Michael Givskov and Liang Yang",
year = "2017",
doi = "10.1128/AAC.01088-17",
language = "English",
volume = "61",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "10",

}

RIS

TY - JOUR

T1 - In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

AU - Roizman, Dan

AU - Vidaillac, Celine

AU - Givskov, Michael

AU - Yang, Liang

PY - 2017

Y1 - 2017

N2 - As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.

AB - As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.

KW - antibiotic resistance

KW - biofilms

KW - cyclic di-GMP

KW - dispersal

KW - synergism

U2 - 10.1128/AAC.01088-17

DO - 10.1128/AAC.01088-17

M3 - Journal article

C2 - 28760898

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 10

M1 - e01088-17

ER -

ID: 184546017