Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms. / Alhede, Morten; Alhede, Maria; Bjarnsholt, Thomas.
Antibiofilm Agents. ed. / Kendra Rumbaugh. Vol. 8 Springer Publishing Company, 2014. p. 257-272 (Springer Series on Biofilms, Vol. 8).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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TY - CHAP
T1 - Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms
AU - Alhede, Morten
AU - Alhede, Maria
AU - Bjarnsholt, Thomas
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Pseudomonas aeruginosa causes infection in all parts of the human body. The bacterium is naturally resistant to a wide range of antibiotics. In addition to resistance mechanisms such as efflux pumps, the ability to form aggregates, known as biofilm, further reduces Pseudomonas aeruginosa’s susceptibility to antibiotics. The presence of such biofilms is acknowledged to equal a persistent infection due to their inherent high tolerance to all antimicrobials and immune cells. In this chapter we discuss the mechanisms of biofilm tolerance. The latest biofilm research is reviewed and future treatment strategies such as quorum sensing inhibitors, silver, and antibodies are thoroughly evaluated.
AB - Pseudomonas aeruginosa causes infection in all parts of the human body. The bacterium is naturally resistant to a wide range of antibiotics. In addition to resistance mechanisms such as efflux pumps, the ability to form aggregates, known as biofilm, further reduces Pseudomonas aeruginosa’s susceptibility to antibiotics. The presence of such biofilms is acknowledged to equal a persistent infection due to their inherent high tolerance to all antimicrobials and immune cells. In this chapter we discuss the mechanisms of biofilm tolerance. The latest biofilm research is reviewed and future treatment strategies such as quorum sensing inhibitors, silver, and antibodies are thoroughly evaluated.
M3 - Book chapter
SN - 978-3-642-53832-2
VL - 8
T3 - Springer Series on Biofilms
SP - 257
EP - 272
BT - Antibiofilm Agents
A2 - Rumbaugh, Kendra
PB - Springer Publishing Company
ER -
ID: 112933602