Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
Pseudomonas aeruginosa causes infection in all parts of the human body. The bacterium is naturally resistant to a wide range of antibiotics. In addition to resistance mechanisms such as efflux pumps, the ability to form aggregates, known as biofilm, further reduces Pseudomonas aeruginosa’s susceptibility to antibiotics. The presence of such biofilms is acknowledged to equal a persistent infection due to their inherent high tolerance to all antimicrobials and immune cells. In this chapter we discuss the mechanisms of biofilm tolerance. The latest biofilm research is reviewed and future treatment strategies such as quorum sensing inhibitors, silver, and antibodies are thoroughly evaluated.
Original language | English |
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Title of host publication | Antibiofilm Agents |
Editors | Kendra Rumbaugh |
Number of pages | 16 |
Volume | 8 |
Publisher | Springer Publishing Company |
Publication date | 1 Jan 2014 |
Pages | 257-272 |
ISBN (Print) | 978-3-642-53832-2 |
ISBN (Electronic) | 978-3-642-53833-9 |
Publication status | Published - 1 Jan 2014 |
Series | Springer Series on Biofilms |
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Volume | 8 |
ID: 112933602