Oxidative Modification of Tryptophan-Containing Peptides

Research output: Contribution to journal › Journal article › Research › peer-review

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Oxidative Modification of Tryptophan-Containing Peptides. / Petersen, Jonas; Christensen, Katrine E.; Nielsen, Mathias T.; Mortensen, Kim T.; Komnatnyy, Vitaly V.; Nielsen, Thomas Eiland; Qvortrup, Katrine.

In: ACS Combinatorial Science, Vol. 20, No. 6, 2018, p. 344-349.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, J, Christensen, KE, Nielsen, MT, Mortensen, KT, Komnatnyy, VV, Nielsen, TE & Qvortrup, K 2018, 'Oxidative Modification of Tryptophan-Containing Peptides', ACS Combinatorial Science, vol. 20, no. 6, pp. 344-349. https://doi.org/10.1021/acscombsci.8b00014

APA

Petersen, J., Christensen, K. E., Nielsen, M. T., Mortensen, K. T., Komnatnyy, V. V., Nielsen, T. E., & Qvortrup, K. (2018). Oxidative Modification of Tryptophan-Containing Peptides. ACS Combinatorial Science, 20(6), 344-349. https://doi.org/10.1021/acscombsci.8b00014

Vancouver

Petersen J, Christensen KE, Nielsen MT, Mortensen KT, Komnatnyy VV, Nielsen TE et al. Oxidative Modification of Tryptophan-Containing Peptides. ACS Combinatorial Science. 2018;20(6):344-349. https://doi.org/10.1021/acscombsci.8b00014

Author

Petersen, Jonas ; Christensen, Katrine E. ; Nielsen, Mathias T. ; Mortensen, Kim T. ; Komnatnyy, Vitaly V. ; Nielsen, Thomas Eiland ; Qvortrup, Katrine. / Oxidative Modification of Tryptophan-Containing Peptides. In: ACS Combinatorial Science. 2018 ; Vol. 20, No. 6. pp. 344-349.

Bibtex

@article{446de26051364b2f80b264920ca3232e,
title = "Oxidative Modification of Tryptophan-Containing Peptides",
abstract = "We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclodehydration between the peptide backbone and the indole side chain of tryptophan to form a fully conjugated indolyl-oxazole moiety. The modified peptides show a characteristic and significant emission maximum at 425 nm, thus making the method a useful strategy for fluorescence labeling.",
author = "Jonas Petersen and Christensen, {Katrine E.} and Nielsen, {Mathias T.} and Mortensen, {Kim T.} and Komnatnyy, {Vitaly V.} and Nielsen, {Thomas Eiland} and Katrine Qvortrup",
note = "doi: 10.1021/acscombsci.8b00014",
year = "2018",
doi = "10.1021/acscombsci.8b00014",
language = "Dansk",
volume = "20",
pages = "344--349",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "ACS Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Oxidative Modification of Tryptophan-Containing Peptides

AU - Petersen, Jonas

AU - Christensen, Katrine E.

AU - Nielsen, Mathias T.

AU - Mortensen, Kim T.

AU - Komnatnyy, Vitaly V.

AU - Nielsen, Thomas Eiland

AU - Qvortrup, Katrine

N1 - doi: 10.1021/acscombsci.8b00014

PY - 2018

Y1 - 2018

N2 - We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclodehydration between the peptide backbone and the indole side chain of tryptophan to form a fully conjugated indolyl-oxazole moiety. The modified peptides show a characteristic and significant emission maximum at 425 nm, thus making the method a useful strategy for fluorescence labeling.

AB - We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclodehydration between the peptide backbone and the indole side chain of tryptophan to form a fully conjugated indolyl-oxazole moiety. The modified peptides show a characteristic and significant emission maximum at 425 nm, thus making the method a useful strategy for fluorescence labeling.

U2 - 10.1021/acscombsci.8b00014

DO - 10.1021/acscombsci.8b00014

M3 - Tidsskriftartikel

C2 - 29719155

VL - 20

SP - 344

EP - 349

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

SN - 2156-8952

IS - 6

ER -

ID: 199420235