Oxidative Modification of Tryptophan-Containing Peptides
Research output: Contribution to journal › Journal article › Research › peer-review
We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclodehydration between the peptide backbone and the indole side chain of tryptophan to form a fully conjugated indolyl-oxazole moiety. The modified peptides show a characteristic and significant emission maximum at 425 nm, thus making the method a useful strategy for fluorescence labeling.
Original language | Danish |
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Journal | ACS Combinatorial Science |
Volume | 20 |
Issue number | 6 |
Pages (from-to) | 344-349 |
Number of pages | 6 |
ISSN | 2156-8952 |
DOIs | |
Publication status | Published - 2018 |
ID: 199420235