Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region. / Campbell, J I; Ciofu, O; Høiby, N.

In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 6, 1997, p. 1380-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Campbell, JI, Ciofu, O & Høiby, N 1997, 'Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.', Antimicrobial Agents and Chemotherapy, vol. 41, no. 6, pp. 1380-4.

APA

Campbell, J. I., Ciofu, O., & Høiby, N. (1997). Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region. Antimicrobial Agents and Chemotherapy, 41(6), 1380-4.

Vancouver

Campbell JI, Ciofu O, Høiby N. Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region. Antimicrobial Agents and Chemotherapy. 1997;41(6):1380-4.

Author

Campbell, J I ; Ciofu, O ; Høiby, N. / Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region. In: Antimicrobial Agents and Chemotherapy. 1997 ; Vol. 41, No. 6. pp. 1380-4.

Bibtex

@article{62d4c020ba2111ddae57000ea68e967b,
title = "Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.",
abstract = "Pseudomonas aeruginosa isolates from 1 of 17 cystic fibrosis patients produced secondary beta-lactamase in addition to the ampC beta-lactamase. Isolates were grouped into three beta-lactamase expression phenotypes: (i) beta-lactam sensitive, low basal levels and inducible beta-lactamase production; (ii) beta-lactam resistant, moderate basal levels and hyperinducible beta-lactamase production; (iii) beta-lactam resistant, high basal levels and constitutive beta-lactamase production. Apart from a base substitution in the ampR-ampC intergenic region of an isolate with moderate-basal-level and hyperinducible beta-lactamase production, sensitive and resistant strains were identical in their ampC-ampR genetic regions. Thus, enhanced beta-lactamase expression is due to mutations in regulatory proteins other than AmpR.",
author = "Campbell, {J I} and O Ciofu and N H{\o}iby",
note = "Keywords: Chronic Disease; Cystic Fibrosis; DNA, Bacterial; Gene Amplification; Genes, Bacterial; Humans; Mutation; Phenotype; Plasmids; Promoter Regions (Genetics); Pseudomonas aeruginosa; Restriction Mapping; beta-Lactam Resistance; beta-Lactamases",
year = "1997",
language = "English",
volume = "41",
pages = "1380--4",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "6",

}

RIS

TY - JOUR

T1 - Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

AU - Campbell, J I

AU - Ciofu, O

AU - Høiby, N

N1 - Keywords: Chronic Disease; Cystic Fibrosis; DNA, Bacterial; Gene Amplification; Genes, Bacterial; Humans; Mutation; Phenotype; Plasmids; Promoter Regions (Genetics); Pseudomonas aeruginosa; Restriction Mapping; beta-Lactam Resistance; beta-Lactamases

PY - 1997

Y1 - 1997

N2 - Pseudomonas aeruginosa isolates from 1 of 17 cystic fibrosis patients produced secondary beta-lactamase in addition to the ampC beta-lactamase. Isolates were grouped into three beta-lactamase expression phenotypes: (i) beta-lactam sensitive, low basal levels and inducible beta-lactamase production; (ii) beta-lactam resistant, moderate basal levels and hyperinducible beta-lactamase production; (iii) beta-lactam resistant, high basal levels and constitutive beta-lactamase production. Apart from a base substitution in the ampR-ampC intergenic region of an isolate with moderate-basal-level and hyperinducible beta-lactamase production, sensitive and resistant strains were identical in their ampC-ampR genetic regions. Thus, enhanced beta-lactamase expression is due to mutations in regulatory proteins other than AmpR.

AB - Pseudomonas aeruginosa isolates from 1 of 17 cystic fibrosis patients produced secondary beta-lactamase in addition to the ampC beta-lactamase. Isolates were grouped into three beta-lactamase expression phenotypes: (i) beta-lactam sensitive, low basal levels and inducible beta-lactamase production; (ii) beta-lactam resistant, moderate basal levels and hyperinducible beta-lactamase production; (iii) beta-lactam resistant, high basal levels and constitutive beta-lactamase production. Apart from a base substitution in the ampR-ampC intergenic region of an isolate with moderate-basal-level and hyperinducible beta-lactamase production, sensitive and resistant strains were identical in their ampC-ampR genetic regions. Thus, enhanced beta-lactamase expression is due to mutations in regulatory proteins other than AmpR.

M3 - Journal article

C2 - 9174204

VL - 41

SP - 1380

EP - 1384

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 6

ER -

ID: 8745042