Evolution in Biofilms
The group aims at improving the treatment of biofilm-related infections by studying the evolution in biofilms with special interest in the development of resistance to antimicrobials and in understanding the role of the immune response in bacterial evolution. The group is also engaged in investigating new biofilm treatment strategies including bacteriophage treatment.
Antimicrobial resistance (AMR) is a leading cause of death around the world urging research to improve our understanding of this important human health threat and to develop solutions.
We want to answer fundamental questions on mutagenesis leading to AMR in biofilm-growing pathogens and investigate new therapeutic solutions.
Three main questions wished to be answered:
- How do bacteria adaptively evolve when growing in biofilms exposed to antimicrobial agents, such as antibiotics and bacteriophages?
- How does host immunity influence the evolution of antibiotic resistance?
- How do we optimize the treatment of biofilm infections preventing AMR development?
- Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat
- Aase og Ejnar Danielsens Fond
- Independent Research Fund Denmark
We collaborate with:
- DTU Bioengineering, Institut for Bioteknologi og Biomedicin, Denmark
- KU, Marine Biological Section, Denmark
- Institute of Pharmacy, Ku, Copenhagen, Denmark
- University of Leiden, Division of Systems Biomedicine and Pharmacology, the Leiden Academic Centre for Drug Research (LACDR), The Netherlands
- Ciberes-IDIBAPS, University of Barcelona, Spain
- Bereichsleiterin Laborforschung, Institut für Infektionsmedizin und Krankenhaushygiene, Jena, Germany
- Helmholtz Centre for Infection Research, Hannover, Germany
- Universitat des les Illes Balears, Palma de Mallorca, Spain
Staff list
| Name | Title | Phone | |
|---|---|---|---|
| Ciofu, Oana | Professor | +4535327899 | |
| Higazy, Doaa | Postdoc | ||
| Mørk, Louise | Laboratory Technician | +4535336603 |