Clinical and Translational Biofilm

Based both at Costerton Biofilm Center and at Department for Clinical Microbiology (DCM), Rigshospitalet, our research is translational, focusing on taking new anti-biofilm treatments to clinical use. This involves development of relevant models as well as a well-established clinical network.

 

 

 

Improved understanding of biofilm infections and host responses. To improve treatment options for these infections. The focus is chronic lung, urinary tract and wound infections as well as infective endocarditis and endovascular prosthesis infections. The research involves in vitro and in vivo model systems as well as investigations on human samples and clinical testing.

 

 

 

 

 

 

 

 

 

Previous we have received major funding from:

  • ABT Fund
  • The Innovation Fund
  • The Novo Nordic Foundation
  • Rigshospitalets Forskningspulje
  • Svenska Sällskapet för Medicinsk Forsknings

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Besides the essential clinical collaboration on a daily basis on clinical microbiology advise, we have an extensive collaboration between Department of Clinical Microbiology (DCM), Rigshospitalet (RH) and CBC with Prof. Oana Ciofu, Prof. Thomas Bjarnsholt, Prof. Tim Tolker-Nielsen, Prof. Michael Givskov and Prof., MD Niels Høiby and ass. Prof. Peter Østrup Jensen.

I have clinical collaborations with several cardiologists, especially Prof., MD Henning Bundgaard (RH), Prof., MD Kasper Iversen (Herlev Hospital) and consultant Emil Fosbøl (RH). Prof., MD Ole Hyldegaard is an important collaborator within our HBOT research.

We also collaborate with Prof., MD Fin Biering-Sørensen (RH) and Prof., MD Andreas Røder (RH) on urinary tract infections. Concerning the chronic wounds, we collaborate with Prof. Magnus Ågren and consultant Klaus Kirketerp-Møller at The Copenhagen Wound Center (Bispebjerg Hospital), as well as consultant Hannah Trøstrup Petersen.

Internationally, we collaborate with associate prof Johan GC van Hasselt, Leiden University and Prof. Trond Flægstad and associate prof. Pauline Cavanagh at Tromsø University. We collaborate with the Copenhagen CF centre, and DCMs around Denmark

 

    • Moser, C., Jensen, PO., Kobayashi, O., Hougen HP., Song, Z., Rygaard J., Kharazmi, A., Høiby, N. Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. Clin Exp Immunol. 2002. 127: 206-13. 

    • Christophersen LJ, Trøstrup H, Damlund DSM, Bjarnsholt T, Thomsen K, Jensen PØ, Hougen HP, Høiby N, Moser C. Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection. CEI 2012; 170:222-30.

    • Trøstrup H, Lerche CJ, Christophersen LJ, Thomsen K, Jensen PØ, Høiby N, Moser C. Chronic Pseudomonas aeruginosa Biofilm Infection Impairs Murine S100A8/A9 and Neutrophil Effector Cytokines - Implications for Delayed Wound Closure? Pathogens and Disease 2017. 18(7). doi: 10.1093/femspd/ftx068.

    • Thomsen K, Christophersen L, Bjarnsholt T, Jensen PØ, Moser C, Høiby N. Anti-Pseudomonas aeruginosa IgY antibodies promote specific bacterial aggregation and internalization in human polymorphonuclear neutrophils. IAI 2015. 83:2686-93.

    • Cao B, Christophersen L, Thomsen K, Sønderholm M, Bjarnsholt T, Jensen PØ, Høiby N, Moser C. Antibiotic Penetration and Bacterial Killing in a Pseudomonas aeruginosa Biofilm Model. JAC 2015. 70:2057-63.

    • Høiby, T. Bjarnsholt, C. Moser, GL Bassi, T. Coenye, G. Donelli, L. Hall-Stoodley, V. Holá, C. Imbert, K. Kirketerp-Møller, D. Lebeaux, A. Oliver, A. Ullmann and C. Williams for the ESCMID Study Group for Biofilms (ESGB). ESCMID* guideline for the diagnosis and treatment of biofilm infections. CMI 2015. 21: Suppl 1: S1-25.

    • Wu H, Moser C, Wang H-Z, Høiby N, Song N. Strategies for combatting bacterial biofilm infections. Int J Oral Science 2015; 7:1-7.

    • Lerche C, Christophersen LJ, Kolpen M, Nielsen PR, Trøstrup H, Thomsen K, Hyldegaard O, Bundgaard H, Jensen PØ, Høiby N, Moser C. Hyperbaric Oxygen Treatment Augments Tobramycin Efficacy in Experimental Staphylococcus aureus Int J Antimicr Agents 2017, 50:406-12.

    • Claus Moser, Hannah Trøstrup Pedersen, Christian Johan Lerche, Mette Kolpen, Laura Line, Kim Thomsen, Niels Høiby, Peter Østrup Jensen. Biofilms and host response – helpful or harmful. APMIS 125(4): 320-38, 2017.

    • Laulund ASB, Trøstrup H, Lerche CJ, Thomsen K, Christophersen L, Calum H, Høiby N, Moser C. Synergistic effect of immunomodulatory S100A8/A9 and ciprofloxacin against Pseudomonas aeruginosa biofilm in a murine chronic wound model. Pathogens Disease. 2020 Jul 1;78(5):ftz027. doi: 10.1093/femspd/ftz027.

    • Kasper Iversen, Nikolaj Ihlemann, Sabine Gill, Trine Madsen, Hanne Elming, Kaare Troels Jensen, Niels Eske Bruun, Dan Eik Høfsten, Kurt Fursted, Jens Jørgen Christensen, Martin Schultz, Christine Klein, Emil Loldrup Fosbøl, Flemming Rosenvinge, Henrik Carl Schønheyder, Lars Køber, Christian Torp-Pedersen, Jannick Helweg-Larsen, Niels Tønder, Claus Moser, Henning Bundgaard. Partial oral versus intravenous antibiotic treatment of endocarditis. NEJM; 380(5):415-424.

    • Franziska A. Schwartz, Lars Christophersen, Anne Sofie Laulund, Rasmus Lundquist, Christian Lerche, Pia Rude Nielsen, Henning Bundgaard, Niels Høiby, Claus Moser. Novel human in vitro vegetation simulation model for infective endocarditis. APMIS. Nov;129(11):653-662.

    • Franziska A. Schwartz1, Lars Christophersen1, Kim Thomsen1, Sara Bækdahl1, Maria Pals Bendixen1, Mette Jørgensen1, Ida Kirstine Bull Rasmussen1, Anne Sofie Laulund1, Niels Høiby1,2, Claus Moser. Patient Urin antistoffer. Chicken IgY reduces the risk of Pseudomonas aeruginosa urinary tract infections in a murine model. Frontiers in Microbiology, section Infectious Agents and Disease. 2022, accepted for publication.

    • Christian Lerche, Franziska Schwartz, Mia Pries-Heje, Emil Fosbøl, Kasper Iversen, Peter Østrup Jensen, Niels Høiby, Ole Hyldegaard, Henning Bundgaard, Claus Moser. Potential advances of adjunctive hyperbaric oxygen therapy in infective endocarditis. Frontiers in Cellular and Infection Microbiology, Feb 3;12:805964. doi: 10.3389/fcimb.2022.805964. eCollection 2022.

    • Oana Ciofu, Claus Moser, Peter Østrup Jensen, Niels Høiby. Tolerance and Resistance of Biofilm Infections. Review Nature 2022. Accepted.

 

 

 

Ongoing projects in the Moser Group

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Professor Claus Moser

Claus Moser
Professor

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Meet the Moser Group

Staff list

Name Title Phone E-mail
Calum, Henrik Pierre Part-time Lecturer   E-mail
Moser, Claus Ernst Professor +4535456428 E-mail