Thomas Eiland Nielsen
Affiliate Professor
Bacteriology
Nørre Allé 14
2200 København N
- 2011
- Published
A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins
Nandurkar, N. S., Petersen, R., Qvortrup, K., Komnatnyy, V. V., Taveras, K. M., Le Quement, S. T., Frauenlob, R., Givskov, Michael & Nielsen, Thomas Eiland, 28 Dec 2011, In: Tetrahedron Letters. 52, 52, p. 7121-7124 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database
Tan, S. Y. Y., Chua, S. L., Chen, Y., Rice, S. A., Kjelleberg, S., Nielsen, Thomas Eiland, Yang, L. & Givskov, Michael, Nov 2013, In: Antimicrobial Agents and Chemotherapy. 57, 11, p. 5629-5641 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics
Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, Thomas Eiland, 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation
Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation
Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A broad range quorum sensing inhibitor working through sRNA inhibition
Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
Palmer, D., Gonçalves, J. P. L., Hansen, L. V., Wu, B., Hald, H., Schoffelen, S., Diness, Frederik, Le Quement, S. T., Nielsen, Thomas Eiland & Meldal, Morten Peter, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8716-8730 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions
Ishoey, M., Petersen, R. G., Petersen, M. A., Wu, P., Clausen, M. H. & Nielsen, Thomas Eiland, 2017, In: Chemical Communications. 53, 68, p. 9410-9413Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kinase Inhibitors
Wu, P., Givskov, Michael & Nielsen, Thomas Eiland, 2017, Drug Selectivity: An Evolving Concept in Medicinal Chemistry. Wiley-Interscience, p. 33-53 21 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Scaffold Diversity from N-Acyliminium Ions
Wu, P. & Nielsen, Thomas Eiland, 2017, In: Chemical Reviews. 117, 12, p. 7811-7856 46 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing
Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Wu, B., Su, H. & Yang, L., 2017, bioRxiv, 27 p.Research output: Working paper › Preprint › Research
- Published
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors
Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Bead-based screening in chemical biology and drug discovery
Komnatnyy, V. V., Nielsen, Thomas Eiland & Qvortrup, K., 2018, In: Chemical Communications. 54, 50, p. 6759-6771 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidative Modification of Tryptophan-Containing Peptides
Petersen, Jonas Odgaard, Christensen, K. E., Nielsen, M. T., Mortensen, K. T., Komnatnyy, V. V., Nielsen, Thomas Eiland & Qvortrup, K., 2018, In: ACS Combinatorial Science. 20, 6, p. 344-349 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds
Wu, P. & Nielsen, Thomas Eiland, 2018, In: Drug Discovery Today: Technologies. 29, p. 27-33Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Petasis/Diels–Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production
Flagstad, T., Azevedo, C. M. G., Min, G., Willaume, A., Morgentin, R., Nielsen, Thomas Eiland & Clausen, M. H., 2018, In: European Journal of Organic Chemistry. 2018, 36, p. 5023-5029 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Photolabile Linkers for Solid-Phase Synthesis
Mikkelsen, R. J. T., Grier, K. E., Mortensen, K. T., Nielsen, Thomas Eiland & Qvortrup, K., 2018, In: ACS Combinatorial Science. 20, 7, p. 377-379 3 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents
Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Hoong Yam, J. K., Aung, T. T., Beuerman, R. W., Santillan Salido, M. M., Schuster, S. C., Tan, C. H., Givskov, Michael, Yang, L. & Nielsen, Thomas Eiland, 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 3059-3069 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa
Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Liu, X., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Generation of a Heteropolycyclic and sp3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence
Flagstad, T., Azevedo, C. M. G., Troelsen, N. S., Min, G. K., Macé, Y., Willaume, A., Guilleux, R., Velay, M., Bonnet, K., Morgentin, R., Nielsen, Thomas Eiland & Clausen, M. H., 2019, In: European Journal of Organic Chemistry. 2019, 5, p. 1061-1076Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reactivity and Synthetic Applications of Multicomponent Petasis Reactions
Wu, P., Givskov, Michael & Nielsen, Thomas Eiland, 2019, In: Chemical Reviews. 119, 20, p. 11245-11290 46 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation
Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.Research output: Contribution to journal › Review › Research › peer-review
- 2021
- Published
Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms
Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors
Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.Research output: Contribution to journal › Journal article › Research › peer-review
- 2024
- Published
High efficacytreatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilmcompound Disperazol in combination with ciprofloxacin
Hultqvist, Louise Dahl, Andersen, Jens Bo, Nilsson, Carl Martin Peter, Jansen, C. U., Rybtke, Morten Levin, Jakobsen, Tim Holm, Nielsen, Thomas Eiland, Qvortrup, Klaus, Moser, Claus Ernst, Graz, M., Qvortrup, K., Tolker-Nielsen, Tim & Givskov, Michael, Jun 2024, In: Antimicrobial Agents and Chemotherapy. 68, 6Research output: Contribution to journal › Journal article › Research › peer-review
ID: 162434453
Most downloads
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210
downloads
A broad range quorum sensing inhibitor working through sRNA inhibition
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
198
downloads
Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation
Research output: Contribution to journal › Review › Research › peer-review
Published -
162
downloads
Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa
Research output: Contribution to journal › Journal article › Research › peer-review
Published