Michael Givskov
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N, 22 Bygning 22, Building: 22-2-22
Member of:
- 2014
- Published
Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom
Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators
Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacteria-triggered release of antimicrobial agents
Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data
Lauro, F. M., Senstius, S. J., Cullen, J., Neches, R., Jensen, R. M., Brown, M. V., Darling, A. E., Givskov, Michael, McDougald, D., Hoeke, R., Ostrowski, M., Philip, G. K., Paulsen, I. T. & Grzymski, J. J., 2014, In: PLOS Biology. 12, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mariner transposon vector adapted for mutagenesis in oral streptococci
Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Emerging frontiers in detection and control of bacterial biofilms
Tan, S. Y. E., Chew, S. C., Tan, S. Y. Y., Givskov, Michael & Yang, L., 2014, In: Current Opinion in Biotechnology. 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa
Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82
Tay, M., Roizman, D., Cohen, Y., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Genome Announcements. 2, 1, p. 1 1 p., e01161-13.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative genomic analysis of malariamosquito vector-associated novel pathogen elizabethkingia anophelis
Teo, J., Tan, S., Liu, Y., Tay, M., Ding, Y., Li, Y., Kjelleberg, S., Givskov, Michael, Lin, R. T. P. & Yang, L., 2014, In: Genome Biology and Evolution. p. 1158–1165 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier
Tran, C. S., Rangel, S. M., Almblad, H., Kierbel, A., Givskov, Michael, Tolker-Nielsen, Tim, Hauser, A. R. & Engel, J. N., Nov 2014, In: P L o S Pathogens. 10, 11, p. 1-11 12 p., e1004479.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients
Wen, H., Wang, K., Liu, Y., Tay, M., Lauro, F. M., Huang, H., Wu, H., Liang, H., Ding, Y., Givskov, Michael, Chen, Y. & Yang, L., Sep 2014, In: Journal of clinical microbiology. 52, 9, p. 3200-3208 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Radix Ginseng on microbial infections: a narrative review
Wu, H., Høiby, Niels, Yang, L., Givskov, Michael & Song, Z., Apr 2014, In: Journal of Traditional Chinese Medicine. 34, 2, p. 227-233 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response
Bobadilla Fazzini, R. A., Skindersoe, M. E., Bielecki, P., Puchalka, J., Givskov, Michael & Martins sos Santos, V. A. P., 2013, In: Environmental Microbiology Reports. 15, 1, p. 111-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms
Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa
Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR
Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation
Dueholm, M. S., Søndergaard, M., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, Michael, Tolker-Nielsen, Tim, Otzen, D. & Nielsen, P. H., 18 Mar 2013, In: MicrobiologyOpen. 2, p. 365-382 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349
Fazli, M., McCarthy, Y., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, Feb 2013, In: MicrobiologyOpen. 2, 1, p. 105-122 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence
Ferreira, A. A., Silva, I. I., Oliveira, V. V., Becker, J. J., Givskov, Michael, Ryan, R. R., Fernandes, F. & Moreira, L. M., May 2013, In: Applied and Environmental Microbiology. 79, 9, p. 3009-3020 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, , 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors
Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa
Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts
Schwager, S., Agnoli, K., Köthe, M., Feldmann, F., Givskov, Michael, Carlier, A. & Eberl, L., 2013, In: Infection and Immunity. 81, 1, p. 143-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of LasR ligands through a virtual screening approach
Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators
Stacy, D. M., Le Quement, S. T., Hansen, C., Clausen, J. W., Tolker-Nielsen, Tim, Brummond, J. W., Givskov, Michael, Nielsen, T. E. & Blackwell, H. E., 2013, In: Organic & Biomolecular Chemistry. 11, 6, p. 938-54 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative genomic analysis of rapid evolution of an extreme-drug- resistant Acinetobacter baumannii clone
Tan, S., Chua, S. L., Liu, Y., Høiby, Niels, Andersen, L. P., Givskov, Michael, Song, Z. & Yang, L., 2013, In: Genome Biology and Evolution. p. 807–818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database
Tan, S. Y. Y., Chua, S. L., Chen, Y., Rice, S. A., Kjelleberg, S., Nielsen, Thomas Eiland, Yang, L. & Givskov, Michael, Nov 2013, In: Antimicrobial Agents and Chemotherapy. 57, 11, p. 5629-5641 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
First case of E anophelis outbreak in an intensive-care unit
Teo, J., Tan, S. Y. Y., Tay, M., Ding, Y., Kjelleberg, S., Givskov, Michael, Lin, R. T. P. & Yang, L., 2013, In: The Lancet. 382, 9895, p. 855-856 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells
Wang, V. B., Chua, S., Cao, B., Seviour, T., Nesatyy, V. J., Marsili, E., Kjelleberg, S., Givskov, Michael, Tolker-Nielsen, Tim, Song, H., Loo, J. S. C. & Yang, L., 2013, In: PLOS ONE. 8, 5, p. e63129 7 p., e63129.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition
Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Process for the manufacture of ajoene derivatives
Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
- Published
The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms
Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bursting the bubble on bacterial biofilms: a flow cell methodology
Crusz, S. A., Popat, R., Rybtke, Morten Levin, Cámara, M., Givskov, Michael, Tolker-Nielsen, Tim, Diggle, S. P. & Williams, P., 2012, In: Biofouling. 28, 8, p. 835-842 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beyond nutrition: health-promoting foods by quorum-sensing inhibition
Givskov, Michael, 2012, In: Future Microbiology. 7, 9, p. 1025-1028 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing
Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence
Komnatnyy, V. V., Givskov, Michael & Nielsen, T. E., Dec 2012, In: Chemistry. A European Journal. 18, 52, p. 16793-16800 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones
Le Quement, S. T., Flagstad, T., Mikkelsen, R. J. T., Hansen, M. R., Givskov, Michael & Nielsen, T. E., 2012, In: Organic Letters. 14, 2, p. 640-643 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa.
Rybtke, Morten Levin, Borlee, B. R., Murakami, K., Irie, Y., Hentzer, M., Nielsen, T. E., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, 2012, In: Applied and Environmental Microbiology. 78, 15, p. 5060-5069 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combating biofilms
Yang, L., Liu, Y., Wu, H., Song, Z., Høiby, Niels, Molin, S. & Givskov, Michael, 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 146–157Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa
Yang, L., Hengzhuang, W., Wu, H., Damkiaer, S., Jochumsen, N., Song, Z., Givskov, Michael, Høiby, Niels & Molin, S., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 366-376 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms
Zhang, L., Chiang, W., Gao, Q., Givskov, Michael, Tolker-Nielsen, Tim, Yang, L. & Zhang, G., Dec 2012, In: Microbiology. 158, 12, p. 3014-3019 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo
van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Novel and future treatment strategies
Alhede, M., Jakobsen, Tim Holm & Givskov, Michael, 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interfering with bacterial gossip.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 5838523
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
802
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Research output: Contribution to journal › Journal article › Research › peer-review
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328
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Research output: Contribution to journal › Review › Research › peer-review
Published