Michael Givskov

Michael Givskov

Professor

Member of:


    1. 2005
    2. Published

      Involvement of bacterial quorum-sensing signals in spoilage of bean sprouts

      Rasch, M., Andersen, Jens Bo, Nielsen, K. F., Flodgaard, L. R., Christensen, Henrik, Givskov, Michael & Gram, L., 2005, In: Applied and Environmental Microbiology. 71, 6, p. 3321-30 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Nonbioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-Hydroxyoctanoyl)homoserine lactone

      Flodgaard, L. R., Dalgaard, P., Andersen, Jens Bo, Nielsen, K. F., Givskov, Michael & Gram, L., 2005, In: Applied and Environmental Microbiology. 71, 4, p. 2113-20 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model

      Bragonzi, A., Worlitzsch, D., Pier, G. B., Timpert, P., Ulrich, M., Hentzer, M., Andersen, Jens Bo, Givskov, Michael, Conese, M. & Doring, G., 2005, In: Journal of Infectious Diseases. 192, 3, p. 410-9 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, 2005, In: Infection and Immunity. 73, 4, p. 2504-14 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria

      Persson, T., Givskov, Michael & Nielsen, J., 2005, In: Current Medicinal Chemistry. 12, 26, p. 3103-15 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector

      Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Köte, M., Nielsen, J., Eberl, L. & Givskov, Michael, 2005, In: Journal of Bacteriology. 187, 5, p. 1799-814 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors

      Koch, B., Liljefors, T., Persson, T., Nielsen, J., Kjelleberg, S. & Givskov, Michael, 2005, In: Microbiology. 151, Pt 11, p. 3589-602 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Transcriptome analysis of Pseudomonas aeruginosa biofilm development: Anaerobic respiration and iron limitation

      Hentzer, M., Eberl, L. & Givskov, Michael, 2005, In: Biofilms. 2, 1, p. 37-61 25 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Erratum: Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis (Infection and Immunity (2005) 73, 4 (2504-2514))

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, Aug 2005, In: Infection and Immunity. 73, 8, p. 5290 1 p.

      Research output: Contribution to journalComment/debateResearchpeer-review

    12. 2006
    13. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms

      Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, Michael & Tolker-Nielsen, T., 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein

      Schreiber, K., Boes, N., Eschbach, M., Jaensch, L., Wehland, J., Bjarnsholt, T., Givskov, Michael, Hentzer, M. & Schobert, M., 2006, In: Journal of Bacteriology. 188, 2, p. 659-68 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

      Fexby, S., Bjarnsholt, Thomas, Jensen, Peter Østrup, Roos, V., Høiby, Niels, Givskov, Michael & Klemm, P., 2006, In: Infection and Immunity. 75, 1, p. 30-4 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Expedient total synthesis of pyrrothine natural products and analogs

      Hjelmgaard, T., Givskov, Michael & Nielsen, J., 2006, In: Organic & Biomolecular Chemistry. 5, 2, p. 344-8 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Furanones

      de Nys, R., Givskov, Michael, Kumar, N., Kjelleberg, S. & Steinberg, P. D., 2006, In: Progress in Molecular and Subcellular Biology. 42, p. 55-86 31 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Quorum sensing inhibitors: a bargain of effects

      Rasmussen, T. B. & Givskov, Michael, 2006, In: Microbiology. 152, Pt 4, p. 895-904 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Quorum-sensing inhibitors as anti-pathogenic drugs

      Rasmussen, T. B. & Givskov, Michael, 2006, In: International Journal of Medical Microbiology. 296, 2-3, p. 149-61 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional

      Shrout, J. D., Chopp, D. L., Just, C. L., Hentzer, M., Givskov, Michael & Parsek, M. R., 2006, In: Molecular Microbiology. 62, 5, p. 1264-77 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. 2007
    22. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice

      Hoffmann, N., Lee, B., Hentzer, M., Rasmussen, T. B., Song, Z., Johansen, H. K., Givskov, Michael & Høiby, N., 2007, In: Antimicrobial Agents and Chemotherapy. 51, 10, p. 3677-87 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa

      Yang, L., Barken, K. B., Skindersoe, M. E., Christensen, A. B., Givskov, Michael & Tolker-Nielsen, T., 2007, In: Microbiology. 153, Pt 5, p. 1318-28 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing.

      Høiby, Niels, Johansen, Helle Krogh, Ciofu, Oana, Jensen, Peter Østrup, Bjarnsholt, Thomas & Givskov, Michael, 2007, In: Ugeskrift for læger. 169, 48, p. 4163-6 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model

      Hultqvist, Louise Dahl, Moser, C., Jensen, Peter Østrup, Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production

      Kastbjerg, V. G., Nielsen, K. F., Dalsgaard, I., Rasch, M., Bruhn, J. B., Givskov, Michael & Gram, L., 2007, In: Journal of Applied Microbiology. 102, 2, p. 363-74 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Quorum sensing antagonism from marine organisms

      Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, T., de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Quorum sensing antagonism from marine organisms

      Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, Thomas, de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Quorum sensing in Serratia

      Van Houdt, R., Givskov, Michael & Michiels, C. W., 2007, In: FEMS Microbiology Reviews. 31, 4, p. 407-24 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor

      Rasch, M., Kastbjerg, V. G., Bruhn, J. B., Dalsgaard, I., Givskov, Michael & Gram, L., 2007, In: Diseases of Aquatic Organisms. 78, 2, p. 105-13 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens

      Bjarnsholt, T. & Givskov, Michael, 2007, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 362, 1483, p. 1213-22 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent

      Labbate, M., Zhu, H., Thung, L., Bandara, R., Larsen, M. R., Willcox, M. D. P., Givskov, Michael, Rice, S. A. & Kjelleberg, S., 2007, In: Journal of Bacteriology. 189, 7, p. 2702-11 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa

      Jensen, Peter Østrup, Bjarnsholt, Thomas, Phipps, R., Rasmussen, T. B., Calum, H., Christoffersen, L., Moser, C., Williams, P., Pressler, T., Givskov, Michael & Høiby, Niels, 2007, In: Microbiology. 153, Pt 5, p. 1329-38 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Silver against Pseudomonas aeruginosa biofilms

      Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Well-known quorum sensing inhibitors do not affect bacterial quorum sensing-regulated bean sprout spoilage

      Rasch, M., Rasmussen, T. B., Andersen, J. B., Persson, T., Nielsen, J., Givskov, Michael & Gram, L., 2007, In: Journal of Applied Microbiology. 102, 3, p. 826-37 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Microbiological aspects of phyllosoma rearing of the ornate rock lobster Panulirus ornatus

      Bourne, D., Høj, L., Webster, N., Payne, M., Skindersøe, M., Givskov, Michael & Hall, M., 22 Aug 2007, In: Aquaculture. 268, 1-4 SPEC. ISS., p. 274-287 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. 2008
    38. Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae

      Matz, C., Moreno, A. M., Alhede, M., Manefield, M., Hauser, A. R., Givskov, Michael & Kjelleberg, S., 2008, In: ISME Journal. 2, 8, p. 843-852 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Detection and inhibition of bacterial cell-cell communication

      Rice, S. A., McDougald, D., Givskov, Michael & Kjelleberg, S., 2008, In: Methods in Molecular Biology. 431, p. 55-68 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

      Bjarnsholt, Thomas & Givskov, Michael, 2008, In: Current Infectious Disease Reports. 10, 1, p. 22-28 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis

      Willcox, M. D. P., Zhu, H., Conibear, T. C. R., Hume, E. B. H., Givskov, Michael, Kjelleberg, S. & Rice, S. A., 2008, In: Microbiology. 154, Pt 8, p. 2184-94 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms

      Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells

      Kristiansen, S., Bjarnsholt, Thomas, Adeltoft, D., Ifversen, P. & Givskov, Michael, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 116, 5, p. 361-371 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection

      Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Christoffersen, L., Damlund, D. S. M., Alhede, M., Bjarnsholt, Thomas, Hougen, H. P., Givskov, Michael, Jacobsen, G. K. & Høiby, Niels, 2008, In: Clinical and Experimental Immunology. 156, 1, p. 102-110 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Why chronic wounds will not heal: a novel hypothesis

      Bjarnsholt, Thomas, Kirketerp-Møller, K., Jensen, Peter Østrup, Madsen, K. G., Phipps, R. K., Krogfelt, K., Høiby, Niels & Givskov, Michael, 2008, In: Wound Repair and Regeneration. 16, 1, p. 2-10 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Distribution, organization, and ecology of bacteria in chronic wounds

      Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, M., Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

      Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. 2009
    49. Published

      Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

      Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, Louise Dahl, van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Biofilms and type III secretion are not mutually exclusive in Pseudomonas aeruginosa

      Mikkelsen, H., Bond, N. J., Skindersoe, M. E., Givskov, Michael, Lilley, K. S. & Welch, M., 2009, In: Microbiology. 155, Pt 3, p. 687-98 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    51. Published

      Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

      Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. Published

      Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, B., Andersen, A. S., Krogfelt, K. A., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Journal of Clinical Microbiology. 47, 12, p. 4084-9 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    54. Published

      Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis.

      Moser, Claus Ernst, van Gennip, M., Bjarnsholt, Thomas, Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, Henrik Pierre, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2009, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 117, p. 95-107 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    55. Published

      Pseudomonas aeruginosa quorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation

      Skindersoe, M. E., Zeuthen, L. H., Brix, Susanne, Fink, L. N., Lazenby, J., Whittall, C., Williams, P., Diggle, S. P., Frøkiær, Hanne, Cooley, M. & Givskov, Michael, 2009, In: FEMS Immunology and Medical Microbiology. 55, 3, p. 335-45 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    ID: 5838523