Niels Høiby
Professor, No job title
Bacteriology
Blegdamsvej 3B, 2200 København N, 24 Bygning 24, Building: 24-1-16
Member of:
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Extensive endoscopic image-guided sinus surgery decreases BPI-ANCA in patients with cystic fibrosis
Aanæs, Kasper, Rasmussen, N., Pressler, T., Segelmark, M., Johansen, Helle Krogh, Lindberg, U., Høiby, Niels, Carlsson, M., Wieslander, J. & Buchwald, C., 2012, In: Scandinavian Journal of Immunology. 76, 6, p. 573-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
Aanæs, Kasper, Johansen, Helle Krogh, Skov, M., Buchvald, F. F., Hjuler, Thomas, Pressler, T., Høiby, Niels, Nielsen, Kim G. & von Buchwald, Christian, 2013, In: Rhinology. 51, 3, p. 222-230 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization
Aanæs, Kasper, Johansen, Helle Krogh, Poulsen, Steen Seier, Pressler, T., Buchwald, C. & Høiby, Niels, 2012, In: Journal of Cystic Fibrosis. 12, 1, p. 81-87 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Autologous fibrin sealant co-delivered with antibiotics is a robust method for topical antibiotic treatment after sinus surgery
Aanæs, Kasper, Nielsen, Kim G., Arndal, E., von Buchwald, Christian, Pressler, T. & Høiby, Niels, 1 Feb 2021, In: Acta Oto-Laryngologica. 141, 2, p. 181-186 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sinus biofilms in patients with cystic fibrosis: is adjusted eradication therapy needed?
Aanæs, Kasper, Eickhardt, S., Johansen, Helle Krogh, von Buchwald, Christian, Skov, M., Høiby, Niels & Bjarnsholt, Thomas, 2014, In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis
Aanæs, Kasper, Rickelt, L. F., Johansen, Helle Krogh, von Buchwald, Christian, Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2011, In: Journal of Cystic Fibrosis. 10, 2, p. 114-120 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The evolutionary trajectories of P. aeruginosa in biofilm and planktonic growth modes exposed to ciprofloxacin: beyond selection of antibiotic resistance
Ahmed, M. N., Abdelsamad, A., Wassermann, T., Porse, A., Becker, J., Sommer, M. O. A., Høiby, Niels & Ciofu, Oana, 2020, In: npj Biofilms and Microbiomes. 6, 1, 10 p., 28.Research output: Contribution to journal › Journal article › Research › peer-review
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Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms
Ahmed, M. N., Porse, A., Abdelsamad, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 2019, In: Antimicrobial Agents and Chemotherapy. 63, 10, 12 p., e00766-19.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin
Ahmed, M. N. A., Porse, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 1 Aug 2018, In: Antimicrobial Agents and Chemotherapy. 62, 8, 12 p., e00320-18.Research output: Contribution to journal › Journal article › Research › peer-review
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Sinus surgery postpones chronic gram-negative lung infection: Cohort study of 106 patients with cystic fibrosis
Alanin, M. C., Aanæs, Kasper, Høiby, Niels, Pressler, T., Skov, M., Nielsen, K. G., Taylor-Robinson, D., Waldmann, E., Johansen, Helle Krogh & von Buchwald, Christian, 2016, In: Rhinology. 54, 3, p. 206-213 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A longitudinal study of lung bacterial pathogens in patients with primary ciliary dyskinesia
Alanin, M. C., Nielsen, K. G., von Buchwald, Christian, Skov, M., Aanæs, Kasper, Høiby, Niels & Johansen, Helle Krogh, Dec 2015, In: Clinical Microbiology and Infection. 21, 12, p. 1093.e1–1093.e7 7 p., 1093.e.Research output: Contribution to journal › Journal article › Research › peer-review
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Sinus surgery can improve quality of life, lung infections, and lung function in patients with primary ciliary dyskinesia
Alanin, M. C., Aanæs, Kasper, Høiby, Niels, Pressler, T., Skov, M., Nielsen, Kim G., Johansen, Helle Krogh & von Buchwald, Christian, Mar 2017, In: International Forum of Allergy Rhinology. 7, 3, p. 240-247Research output: Contribution to journal › Journal article › Research › peer-review
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Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia
Alanin, M. C., Johansen, Helle Krogh, Aanaes, K., Høiby, Niels, Pressler, T., Skov, M., Nielsen, K. G. & von Buchwald, Christian, Jan 2015, In: Acta Oto-Laryngologica. 135, 1, p. 58-63 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Can secretory immunoglobulin A in saliva predict a change in lung infection status in patients with cystic fibrosis? A prospective pilot study
Alanin, M. C., Pressler, T., Aanæs, Kasper, Ekstrøm, Claus Thorn, Skov, M., Johansen, Helle Krogh, Nielsen, Kim G., von Buchwald, Christian & Høiby, Niels, 2018, In: Health Services Research. 1, 8, 5 p., e52.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial biofilm formation and treatment in soft tissue fillers
Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.Research output: Contribution to journal › Journal article › Research
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Phenotype of non-attached Pseudomonas aeruginosa microclonies resembles attached biofilm, including reversible antibiotic tolerance
Alhede, M., Qvortrup, K., Allesen-Holm, M., van Gennip, M., Christensen, L., Jensen, Peter Østrup, Nielsen, A., Tolker-Nielsen, T., Høiby, Niels, Givskov, M. C. & Bjarnsholt, Thomas, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, Louise Dahl, van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition
Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms
Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.Research output: Contribution to journal › Journal article › Research › peer-review
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Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs
Arndal, E., Johansen, Helle Krogh, Haagensen, J. A. J., Bartell, J. A., Marvig, R. L., Alanin, M., Aanæs, Kasper, Høiby, Niels, Nielsen, Kim G., Backer, Vibeke & von Buchwald, Christian, 2020, In: The European Respiratory Journal. 55, 1, 4 p., 1901472.Research output: Contribution to journal › Letter › Research › peer-review
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Rapid development in vitro and in vivo of resistance to ceftazidime in biofilm-growing Pseudomonas aeruginosa due to chromosomal beta-lactamase
Bagge, N., Ciofu, Oana, Skovgaard, Lene Theil & Høiby, Niels, Sep 2000, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 108, 9, p. 589-600 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.
Bagge, N., Ciofu, Oana, Hentzer, M., Campbell, J. I. A., Givskov, Michael & Høiby, Niels, 2002, In: Antimicrobial Agents and Chemotherapy. 46, 11, p. 3406-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.
Bagge, N., Hentzer, M., Andersen, Jens Bo, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1168-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.
Bagge, N., Schuster, M., Hentzer, M., Ciofu, Oana, Givskov, Michael, Greenberg, E. P. & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1175-87 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Restriction fragment length polymorphism of rRNA genes for molecular typing of members of the family Legionellaceae.
Bangsborg, Jette Marie, Gerner-Smidt, P., Colding, H., Fiehn, Nils-Erik, Bruun, B. & Høiby, Niels, 1995, In: Journal of Clinical Microbiology. 33, 2, p. 402-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Leginella micdadei flagellin: Expression in Escherichia coli K12 and DNA sequence of the gene
Bangsborg, Jette Marie, Hindersson, P., Shand, G. & Høiby, Niels, 1995, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. p. 869-877Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning and expression of the Legionella micdadei "common antigen" in Escherichia coli
Bangsborg, Jette Marie, Collins, M. T., Høiby, Niels & Hindersson, P., 1989, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 97, 1, p. 14-22 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody response to major cross-reactive Legionella antigens during infection
Bangsborg, Jette Marie, Shand, G. & Høiby, Niels, 1993, Legionella: Current status and emerging perspectives. USA: ASM, p. 26-29Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Cross-reactive Legionella antigens and the antibody response during infection
Bangsborg, Jette Marie, Shand, G., Pearlman, E. & Høiby, Niels, 1991, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 99, 9, p. 854-65 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The E. coli immunosorbent as used in serodiagnosis of Legionella infections studied by crossed immunoelectrophoresis
Bangsborg, Jette Marie, Friis-Møller, A., Rechnitzer, C., Høiby, Niels & Lind, K., 1988, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 96, 2, p. 177-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Legionella micdadei flagellin: expression in Escherichia coli K 12 and DNA sequence of the gene
Bangsborg, Jette Marie, Hindersson, P., Shand, G. & Høiby, Niels, 1995, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 103, 12, p. 869-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of ribotyping and genome fingerprinting of Pseudomonas aeruginosa isolates from cystic fibrosis patients.
Bennekov, T., Colding, H., Ojeniyi, B., Bentzon, M. W. & Høiby, Niels, 1996, In: Journal of Clinical Microbiology. 34, 1, p. 202-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Urinary tract infections with spinal cord lesions: Treatment and prevention
Biering-Sørensen, F., Bagi, P. & Høiby, Niels, 2001, In: Drugs. 61, p. 1275-1287Research output: Contribution to journal › Journal article › Research › peer-review
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Summary and Perspectives
Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C. E., Jensen, P. Ø. & Høiby, N. (eds.). 1st ed. New York. NY. US: Springer Science+Business Media, p. 291-293 3 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115Research output: Contribution to journal › Journal article › Research › peer-review
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Why chronic wounds will not heal: a novel hypothesis
Bjarnsholt, Thomas, Kirketerp-Møller, K., Jensen, Peter Østrup, Madsen, K. G., Phipps, R. K., Krogfelt, K., Høiby, Niels & Givskov, Michael, 2008, In: Wound Repair and Regeneration. 16, 1, p. 2-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Summary and perspectives
Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, 2011, Biofilm Infections. Springer New York, p. 291-294 4 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H. P., Rygaard, J., Moser, C., Eberl, L., Høiby, Niels & Givskov, M. C., 1 Dec 2005, In: Microbiology. 151, Pt 12, p. 3873-80 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent
Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Process for the manufacture of ajoene derivatives
Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
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Silver against Pseudomonas aeruginosa biofilms
Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The in vivo biofilm
Bjarnsholt, Thomas, Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, Claus Ernst, Kühl, Michael, Jensen, Peter Østrup & Høiby, Niels, 2013, In: Trends in Microbiology. 21, 9, p. 466-474 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Methods to classify bacterial pathogens in cystic fibrosis
Bjarnsholt, Thomas, Nielsen, X. C., Johansen, U., Nørgaard, L. & Høiby, Niels, 2011, In: Methods in Molecular Biology. 742, p. 143-71 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiofilm Properties of Acetic Acid
Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent
Bjarnsholt, Thomas, Jensen, P. Ø., Burmølle, M., Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, C., Molin, S., Høiby, Niels & Givskov, M. C., 1 Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding biofilms - Are we there yet?
Bjarnsholt, Thomas, Høiby, Niels, Donelli, G., Imbert, C. & Försberg, A., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 125-126 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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[Debat]
Bjerrum, Lars, Grinsted, P., Søgaard, P., Frimodt-Møller, N., Høiby, Niels & Tvede, M., 2002, In: Ugeskrift for Laeger. 164, 22, p. 2930-2932 3 p.Research output: Contribution to journal › Journal article › Research
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Rifampicin reduces plasma concentration of linezolid in patients with infective endocarditis
Bock, M., Van Hasselt, J. G. C., Schwartz, F., Wang, H., Høiby, N., Fuursted, K., Ihlemann, N., Gill, S., Christiansen, U., Bruun, N. E., Elming, H., Povlsen, J. A., Køber, L., Høfsten, D. E., Fosbøl, E. L., Pries-Heje, M. M., Christensen, J. J., Rosenvinge, F. S., Torp-Pedersen, C., Helweg-Larsen, J. & 4 others, , 2023, In: The Journal of antimicrobial chemotherapy. 78, 12, p. 2840–2848 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Attainment of Target Antibiotic Levels by Oral Treatment of Left-sided Infective Endocarditis: A POET Substudy
Bock, M., Theut, A. M., van Hasselt, J. G. C., Wang, H., Fuursted, K., Hoiby, N., Lerche, C. J., Ihlemann, N., Gill, S., Christiansen, U., Nielsen, H. L., Lemming, L., Elming, H., Povlsen, J. A., Bruun, N. E., Hofsten, D., Fosbøl, E. L., Kober, L., Schultz, M., Pries-Heje, M. M. & 9 others, , 2023, In: Clinical Infectious Diseases. 77, 2, p. 242–251 10 p., 168.Research output: Contribution to journal › Journal article › Research › peer-review
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Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection
Bohn, Y. T., Brandes, G., Rakhimova, E., Horatzek, S., Salunkhe, P., Munder, A., van Barneveld, A., Jordan, D., Bredenbruch, F., Häussler, S., Riedel, K., Eberl, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, C., Høiby, Niels, Tümmler, B. & Wiehlmann, L., 2008, In: Molecular Microbiology. 71, 3, p. 730-47 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model
Brinch, K. S., Sandberg, A., Baudoux, P., Van Bambeke, F., Tulkens, P. M., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 11, p. 4801-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin
Brinch, K. S., Tulkens, P. M., Van Bambeke, F., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 1 Aug 2010, In: Journal of Antimicrobial Chemotherapy. 65, 8, p. 1720-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of antidrug antibodies on plectasin efficacy and pharmacokinetics
Brinch, K. S., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 11, p. 4794-800 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation
Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Cytokine and surface receptor diversity of NK cells in resistant C3H/HeN and susceptible BALB/c mice with chronic Pseudomonas aeruginosa lung infection
Calum, H., Moser, C., Jensen, P. Ø., Shirai, R. & Høiby, Niels, 2003, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 111, 9, p. 891-897 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Murine burn lesion model for studying acute and chronic wound infections
Calum, Henrik Pierre, Trøstrup, H., Laulund, A. S., Thomsen, K., Christophersen, L., Høiby, Niels & Moser, Claus Ernst, 2022, In: APMIS. 130, 7, p. 477-490 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Cytokine and surface receptor diversity of NK cells in resistant C3H/HeN and susceptible BALB/c mice with chronic Pseudomonas aeruginosa lung infection
Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Shirai, R. & Høiby, Niels, Sep 2003, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 111, 9, p. 891-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection
Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Christoffersen, L., Damlund, D. S. M., Alhede, M., Bjarnsholt, Thomas, Hougen, H. P., Givskov, Michael, Jacobsen, G. K. & Høiby, Niels, 2008, In: Clinical and Experimental Immunology. 156, 1, p. 102-110 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early IL-2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN-dominating response and reduced lung pathology
Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Bjarnsholt, Thomas, Givskov, Michael & Høiby, Niels, 2020, In: APMIS - Journal of Pathology, Microbiology and Immunology. 128, 12, p. 647-653Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.
Campbell, J. I., Ciofu, Oana & Høiby, Niels, 1997, In: Antimicrobial Agents and Chemotherapy. 41, 6, p. 1380-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model
Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In: The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diffusion retardation by binding of tobramycin in an alginate biofilm model
Cao, B., Christophersen, L., Kolpen, Mette, Jensen, Peter Østrup, Sneppen, Kim, Høiby, Niels, Moser, Claus Ernst & Sams, T., 21 Apr 2016, In: P L o S One. 11, 4, 11 p., e0153616.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients
Caçador, N. C., Paulino da Costa Capizzani, C., Monteiro Marin Torres, L. A. G., Galetti, R., Ciofu, Oana, Lúcia da Costa Darini, A. & Høiby, Niels, 2018, In: PLoS ONE. 13, 11, 11 p., e0208013.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms
Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antimicrobial efficacy of furanone C30 and tobramycin against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Christensen, L., van Gennip, M., Alhede, M., Kumar, N., Kjelleberg, S., Høiby, Niels, Bjarnsholt, Thomas & Givskov, M., 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model
Hultqvist, Louise Dahl, Moser, C., Jensen, Peter Østrup, Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection
Christophersen, L. J., Trøstrup, H., Damlund, D. S. M., Bjarnsholt, Thomas, Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, 2012, In: Experimental and clinical endocrinology. 170, 2, p. 222-30 10 p., 170.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments
Christophersen, L., Schwartz, F. A., Lerche, C. J., Svanekjær, T., Kragh, K. N., Laulund, A. S., Thomsen, K., Henneberg, K. Å., Sams, T., Høiby, Niels & Moser, Claus Ernst, 2020, In: Journal of Cystic Fibrosis. 19, 6, p. 996-1003Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased severity of chronic Pseuomonas aeruginosa biofilm infection in the smaller airways of BALB/C mice
Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice exacerbates pulmonary inflammation.
Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Increased severity of chronic Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice
Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis.
Ciofu, Oana, Petersen, T. D., Jensen, P. & Høiby, Niels, 1999, In: Thorax. 54, 2, p. 141-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.
Ciofu, Oana, Beveridge, T. J., Kadurugamuwa, J., Walther-Rasmussen, J. & Høiby, Niels, 2000, In: Journal of Antimicrobial Chemotherapy. 45, 1, p. 9-13 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The influence of allotypes on the IgG subclass response to chromosomal beta-lactamase of Pseudomonas aeruginosa in cystic fibrosis patients.
Ciofu, Oana, Pressler, T., Pandey, J. P. & Høiby, Niels, 1997, In: Clinical and Experimental Immunology. 108, 1, p. 88-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, beta-lactamase activity and RiboPrinting.
Ciofu, Oana, Fussing, V., Bagge, N., Koch, C. & Høiby, Niels, 2001, In: Journal of Antimicrobial Chemotherapy. 48, 3, p. 391-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of antibiotic resistance in Pseudomonas aeruginosa during two decades of antipseudomonal treatment at the Danish CF Center.
Ciofu, Oana, Giwercman, B., Pedersen, S. S. & Høiby, Niels, 1994, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 102, 9, p. 674-80 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams.
Ciofu, Oana, Giwercman, B., Walter-Rasmussen, J., Pressler, T., Pedersen, S. S. & Høiby, Niels, 1995, In: Journal of Antimicrobial Chemotherapy. 35, 2, p. 295-304 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cystic fibrosis: coping with resistance
Ciofu, Oana, Høiby, Niels, Gould, I. M. & Meer, J. W. M. V. D., 2007, Antibiotic policies: fighting resistance. Springer, p. 149-174 25 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants.
Ciofu, Oana, Lee, B., Johannesson, M., Hermansen, N. O., Meyer, P., Høiby, Niels & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 2008, In: Microbiology. 154, Pt 1, p. 103-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants
Ciofu, Oana, Mandsberg, L. F., Bjarnsholt, Thomas, Wassermann, T. & Høiby, Niels, 2010, In: Microbiology. 156, p. 1108-1119 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibodies against beta-lactamase can improve ceftazidime treatment of lung infection with beta-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection.
Ciofu, Oana, Bagge, N. & Høiby, Niels, 2002, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 110, 12, p. 881-91 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Respiratory bacterial infections in cystic fibrosis
Ciofu, Oana, Hansen, C. R. & Høiby, Niels, May 2013, In: Current Opinion in Pulmonary Medicine. 19, 3, p. 251-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene transcription profiles of paired mucoid and non-mucoid P. aeruginosa isolates from sinuses and lungs of patients with cystic fibrosis
Ciofu, O., Johansen, Helle Krogh, Wassermann, T., Aanæs, Kasper, Alhede, M. & Høiby, Niels, 23 May 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.
Ciofu, Oana, Riis, B., Pressler, T., Poulsen, Henrik Enghusen & Høiby, Niels, 2005, In: Antimicrobial Agents and Chemotherapy. 49, 6, p. 2276-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meropenem in cystic fibrosis patients infected with resistant Pseudomonas aeruginosa or Burkholderia cepacia and with hypersensitivity to beta-lactam antibiotics.
Ciofu, Oana, Jensen, T., Pressler, T., Johansen, Helle Krogh, Bender Koch, Christian & Høiby, Niels, 1996, In: Clinical Microbiology and Infection. 2, 2, p. 91-98 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections
Ciofu, Oana, Mandsberg, L. F., Wang, H. & Høiby, Niels, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs
Ciofu, Oana, Johansen, Helle Krogh, Aanæs, Kasper, Wassermann, T., Alhede, M., von Buchwald, Christian & Høiby, Niels, 8 Mar 2013, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12, 6, p. 729-736 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tolerance and resistance of microbial biofilms
Ciofu, Oana, Moser, Claus Ernst, Jensen, Peter Østrup & Høiby, Niels, 2022, In: Nature Reviews Microbiology. 20, p. 621–635Research output: Contribution to journal › Review › Research › peer-review
- Published
Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and control
Collins, M. T., Lisby, G., Moser, C., Chicks, D., Christensen, S., Reichelderfer, M., Høiby, Niels, Harms, B., Thomsen, O. Ø., Skibsted, U. & Binder, V., 2000, In: Journal of Clinical Microbiology. 38, p. 4373-4381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis
Cramer, N., Wiehlmann, L., Ciofu, Oana, Tamm, S., Høiby, Niels & Tümmler, B., Nov 2012, In: PLOS ONE. 7, 11, e50731.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8427
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
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