Niels Høiby
Professor, No job title
Bacteriology
Blegdamsvej 3B, 2200 København N, 24 Bygning 24, Building: 24-1-16
Member of:
- 2010
- Published
Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa
Herrmann, G., Yang, L., Wu, H., Song, Z., Wang, H., Høiby, Niels, Ulrich, M., Molin, S., Riethmüller, J. & Döring, G., 15 Nov 2010, In: The Journal of Infectious Diseases. 202, 10, p. 1585-92 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Små børn får hyppigt bihulebetaendelse
Herløv-Nielsen, H. & Høiby, Niels, 29 Nov 2010, In: Ugeskrift for Laeger. 172, 48, p. 3320-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients
Høiby, Niels, Johansen, Helle Krogh, Moser, Claus Ernst, Ciofu, Oana, Jensen, Peter Østrup, Kolpen, Mette, Mandsberg, L., Givskov, Michael, Molin, S. & Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer, p. 167-184 18 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Anaerobic bacteria in biofilm –and their tolerance to antibiotics
Kragh, K. N., Kühl, Michael, Gregersen, A., Tvede, M., Høiby, Niels & Bjarnsholt, Thomas, 2011.Research output: Contribution to conference › Poster › Research
- Published
- Published
Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis
Aanæs, Kasper, Rickelt, L. F., Johansen, Helle Krogh, von Buchwald, Christian, Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2011, In: Journal of Cystic Fibrosis. 10, 2, p. 114-120 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM)
Mandsberg, L. F., Maciá, M. D., Bergmann, K. R., Christiansen, L., Alhede, M., Kirkby, N., Høiby, Niels, Oliver, A. & Ciofu, Oana, 2011, In: F E M S Microbiology Letters. 324, 1, p. 28-37 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hvad er stafylokokker?
Høiby, Niels, 2011Research output: Other contribution › Net publication - Internet publication › Research
- Published
Methods to classify bacterial pathogens in cystic fibrosis
Bjarnsholt, Thomas, Nielsen, X. C., Johansen, U., Nørgaard, L. & Høiby, Niels, 2011, In: Methods in Molecular Biology. 742, p. 143-71 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients
Lee, B., Schjerling, C. K., Kirkby, N., Hoffmann, N., Borup, R., Molin, S., Høiby, Niels & Ciofu, Oana, 2011, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 119, 4-5, p. 263-74 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prevention of biofilm formation in the soft tissue filler Aquamid
Er, Ö., Kühl, Michael, Tvede, M., Høiby, Niels, Nielsen, A. K. & Bjarnsholt, Thomas, 2011.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Salmonella enterica serovar Typhi and S. Paratyphi A: need to expand the QRDR region?
Walther-Rasmussen, J. & Høiby, Niels, 2011, In: Epidemiology and Infection. 139, 8, p. 1281-1283 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Summary and perspectives
Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, 2011, Biofilm Infections. Springer New York, p. 291-294 4 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The clinical impact of bacterial biofilms
Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65Research output: Contribution to journal › Journal article › Research › peer-review
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The implication of Pseudomonas aeruginosa biofilms in infections
Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2011, In: Journal of Clinical Microbiology. 49, 12, p. 4352-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data
Yang, L., Rau, M. H., Yang, L., Høiby, Niels, Molin, S. & Jelsbak, L., 1 Jan 2011, In: B M C Microbiology. 11, p. 184Research output: Contribution to journal › Journal article › Research › peer-review
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Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
Høiby, Niels, 1 Jan 2011, In: B M C Medicine. 9, p. 32Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Current understanding of multi-species biofilms
Yang, L., Liu, Y., Wu, H., Høiby, Niels, Molin, S. & Song, Z., 1 Apr 2011, In: International Journal of Oral Science. 3, 2, p. 74-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolutionary dynamics of bacteria in a human host environment
Yang, L., Jelsbak, L., Marvig, R. L., Damkiær, S., Workman, C., Rau, M. H., Hansen, S. K., Folkesson, A., Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels, Sommer, M. & Molin, S., 3 May 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7481-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic Pseudomonas aeruginosa infection definition: EuroCareCF Working Group report
Pressler, T., Bohmova, C., Conway, S., Dumcius, S., Hjelte, L., Høiby, Niels, Kollberg, H., Tümmler, B. & Vavrova, V., 1 Jun 2011, In: Journal of Cystic Fibrosis. 10 Suppl 2, p. S75-8Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation
Wu, H., Lee, B., Yang, L., Wang, H., Givskov, Michael, Molin, S., Høiby, Niels & Song, Z., 1 Jun 2011, In: F E M S Immunology and Medical Microbiology. 62, 1, p. 49-56 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, Jul 2011, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 236-244 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Photoactivated Titanium Dioxide Nanopowders and Coating on Planktonic and Biofilm Growth of Pseudomonas aeruginosa
Polo, A., Diamanti, M. V., Bjarnsholt, Thomas, Høiby, Niels, Villa, F., Pedeferri, M. P. & Cappitelli, F., 25 Jul 2011, In: Photochemistry and Photobiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa
Yang, L., Liu, Y., Markussen, T., Høiby, Niels, Tolker-Nielsen, Tim & Molin, S., 1 Aug 2011, In: F E M S Immunology and Medical Microbiology. 62, 3, p. 339-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of microbial diversity in endocarditis using cultivation-independent molecular techniques
Wolff, T. Y., Moser, Claus Ernst, Bundgaard, H., Høiby, Niels, Nielsen, P. H. & Thomsen, T. R., 26 Aug 2011, In: Scandinavian Journal of Infectious Diseases. 43, 11-12, p. 857-869Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms
Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z., Høiby, Niels & Wang, H., Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis
Dalbøge, C. S., Hansen, C. R., Pressler, T., Høiby, Niels & Johansen, Helle Krogh, 1 Sep 2011, In: Journal of Cystic Fibrosis. 10, 5, p. 318-25 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms
Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, 1 Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients
Miller, A. K., Brannon, M. K., Stevens, L., Johansen, Helle Krogh, Selgrade, S. E., Miller, S. I., Høiby, Niels & Moskowitz, S. M., 3 Oct 2011, In: Antimicrobial Agents and Chemotherapy. 55, 12, p. 5761-5769Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection
Christophersen, L. J., Trøstrup, H., Damlund, D. S. M., Bjarnsholt, Thomas, Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, 2012, In: Experimental and clinical endocrinology. 170, 2, p. 222-30 10 p., 170.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combating biofilms
Yang, L., Liu, Y., Wu, H., Song, Z., Høiby, Niels, Molin, S. & Givskov, Michael, 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 146–157Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Culture-dependent and -independent investigations of microbial diversity on urinary catheters
Xu, Y., Moser, Claus Ernst, Abu Al-Soud, W., Sørensen, Søren Johannes, Høiby, Niels, Nielsen, P. H. & Thomsen, T. R., 2012, In: Journal of Clinical Microbiology. 50, 12, p. 3901-3908 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
Hansen, S. K., Rau, M. H., Johansen, Helle Krogh, Ciofu, Oana, Jelsbak, L., Yang, L., Folkesson, A., Jarmer, H. Ø., Aanæs, Kasper, von Buchwald, Christian, Høiby, Niels & Molin, S., 2012, In: I S M E Journal. 6, 1, p. 31-45Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extensive endoscopic image-guided sinus surgery decreases BPI-ANCA in patients with cystic fibrosis
Aanæs, Kasper, Rasmussen, N., Pressler, T., Segelmark, M., Johansen, Helle Krogh, Lindberg, U., Høiby, Niels, Carlsson, M., Wieslander, J. & Buchwald, C., 2012, In: Scandinavian Journal of Immunology. 76, 6, p. 573-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis
Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in Guinea Pigs
Jensen, Peter Østrup, Lykkesfeldt, Jens, Bjarnsholt, Thomas, Hougen, H. P., Høiby, Niels & Ciofu, Oana, 2012, In: Basic & Clinical Pharmacology & Toxicology. 110, 4, p. 353-358 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization
Aanæs, Kasper, Johansen, Helle Krogh, Poulsen, Steen Seier, Pressler, T., Buchwald, C. & Høiby, Niels, 2012, In: Journal of Cystic Fibrosis. 12, 1, p. 81-87 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients
Moskowitz, S. M., Brannon, M. K., Dasgupta, N., Pier, M., Sgambati, N., Miller, A. K., Selgrade, S. E., Miller, S. I., Denton, M., Conway, S. P., Johansen, Helle Krogh & Høiby, Niels, Feb 2012, In: Antimicrobial Agents and Chemotherapy. 56, 2, p. 1019-1030 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing
Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection
Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2683-2690 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production
Sautter, R., Ramos, D., Schneper, L., Ciofu, Oana, Wassermann, T., Koh, C., Heydorn, A., Hentzer, M., Høiby, Niels, Kharazmi, A., Molin, S., Devries, C. A., Ohman, D. E. & Mathee, K., 1 May 2012, In: Gene. 498, 2, p. 242-253 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Process for the manufacture of ajoene derivatives
Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
- Published
Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition
Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections
Ciofu, Oana, Mandsberg, L. F., Wang, H. & Høiby, Niels, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa
Yang, L., Hengzhuang, W., Wu, H., Damkiaer, S., Jochumsen, N., Song, Z., Givskov, Michael, Høiby, Niels & Molin, S., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 366-376 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Towards diagnostic guidelines for biofilm-associated infections
Hall-Stoodley, L., Stoodley, P., Kathju, S., Høiby, Niels, Moser, Claus Ernst, William Costerton, J., Moter, A. & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 127-145 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding biofilms - Are we there yet?
Bjarnsholt, Thomas, Høiby, Niels, Donelli, G., Imbert, C. & Försberg, A., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 125-126 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo
van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa
Marvig, R. L., Søndergaard, M. S. R., Damkiær, S., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., Aug 2012, In: Antimicrobial Agents and Chemotherapy. 56, 8, p. 4519-4521 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis
Cramer, N., Wiehlmann, L., Ciofu, Oana, Tamm, S., Høiby, Niels & Tümmler, B., Nov 2012, In: PLOS ONE. 7, 11, e50731.Research output: Contribution to journal › Journal article › Research › peer-review
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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
Folkesson, A., Jelsbak, L., Yang, L., Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels & Molin, S., Dec 2012, In: Nature Reviews. Microbiology. 10, 12, p. 841-851 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response
Johansen, Helle Krogh, Aanæs, Kasper, Pressler, T., Nielsen, Kim G., Fisker, J., Skov, M., Høiby, Niels & von Buchwald, Christian, Dec 2012, In: Journal of Cystic Fibrosis. 11, 6, p. 525-531 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment of lung infection in patients with cystic fibrosis: current and future strategies
Döring, G., Flume, P., Heijerman, H., Elborn, J. S. & Consensus Study Group, C. S. G., Dec 2012, In: Journal of Cystic Fibrosis. 11, 6, p. 461-479 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
Aanæs, Kasper, Johansen, Helle Krogh, Skov, M., Buchvald, F. F., Hjuler, Thomas, Pressler, T., Høiby, Niels, Nielsen, Kim G. & von Buchwald, Christian, 2013, In: Rhinology. 51, 3, p. 222-230 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative genomic analysis of rapid evolution of an extreme-drug- resistant Acinetobacter baumannii clone
Tan, S., Chua, S. L., Liu, Y., Høiby, Niels, Andersen, L. P., Givskov, Michael, Song, Z. & Yang, L., 2013, In: Genome Biology and Evolution. p. 807–818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, , 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of infectious dose and season on development of hemorrhagic pneumonia in mink caused by Pseudomonas aeruginosa
Salomonsen, C. M., Chriél, M., Jensen, T. H., Rangstrup-Christensen, L., Høiby, Niels & Hammer, Anne Sofie Vedsted, 2013, In: Canadian Journal of Veterinary Research. 77, 3, p. 221-225 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The in vivo biofilm
Bjarnsholt, Thomas, Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, Claus Ernst, Kühl, Michael, Jensen, Peter Østrup & Høiby, Niels, 2013, In: Trends in Microbiology. 21, 9, p. 466-474 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Typing of Pseudomonas aeruginosa from hemorrhagic pneumonia in mink (Neovison vison)
Salomonsen, C. M., Themudo, G. E., Jelsbak, L., Molin, S., Høiby, Niels & Hammer, Anne Sofie Vedsted, 2013, In: Veterinary Microbiology. 163, 1-2, p. 103-109 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A cohort study of the Copenhagen CF Centre eradication strategy against Staphylococcus aureus in patients with CF
Dalbøge, C. S., Pressler, T., Høiby, Niels, Nielsen, Kim G. & Johansen, Helle Krogh, Jan 2013, In: Journal of Cystic Fibrosis. 12, 1, p. 42-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms
Hengzhuang, W., Ciofu, Oana, Yang, L., Wu, H., Song, Z., Oliver, A. & Høiby, Niels, Jan 2013, In: Antimicrobial Agents and Chemotherapy. 57, 1, p. 196-204 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa biofilm aggravates skin inflammatory response in BALB/c mice in a novel chronic wound model
Trøstrup, H., Thomsen, K., Christophersen, L. J., Hougen, H. P., Bjarnsholt, Thomas, Jensen, Peter Østrup, Kirkby, N., Calum, H., Høiby, Niels & Moser, Claus Ernst, Mar 2013, In: Wound Repair and Regeneration. 21, 2, p. 292-299 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs
Ciofu, Oana, Johansen, Helle Krogh, Aanæs, Kasper, Wassermann, T., Alhede, M., von Buchwald, Christian & Høiby, Niels, 8 Mar 2013, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12, 6, p. 729-736 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct sequencing and RipSeq interpretation as a tool for identification of polymicrobial infections
Wolff, T. Y., Eickhardt, S., Björnsdottir, M. K., Moser, Claus Ernst, Bjarnsholt, Thomas, Høiby, Niels & Thomsen, T. R., Apr 2013, In: Journal of Clinical Microbiology. 51, 4, p. 1281-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A non-fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient
Eickhardt, S., Braendstrup, P., Clasen-Linde, E., Jensen, K. E., Alhede, M., Bjarnsholt, Thomas, Høiby, Niels, Vindeløv, L. & Moser, Claus Ernst, May 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 5, p. 456-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms
Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Respiratory bacterial infections in cystic fibrosis
Ciofu, Oana, Hansen, C. R. & Høiby, Niels, May 2013, In: Current Opinion in Pulmonary Medicine. 19, 3, p. 251-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietzia papillomatosis Bacteremia
Rammer, P., Calum, Henrik Pierre, Moser, Claus Ernst, Björnsdóttir, M. K., Smedegaard, H., Høiby, Niels & Bjarnsholt, Thomas, Jun 2013, In: Journal of Clinical Microbiology. 51, 6, p. 1977-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms
Song, Z., Borgwardt, L., Høiby, Niels, Wu, H., Sørensen, T. S. & Borgwardt, A., 7 Jun 2013, In: Orthopedic Reviews. 5, 2, p. 65-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors
Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa
Jørgensen, K. M., Wassermann, T., Jensen, Peter Østrup, Hengzuang, W., Molin, S., Høiby, Niels & Ciofu, Oana, Sep 2013, In: Antimicrobial Agents and Chemotherapy. 57, 9, p. 4215-21 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Staphylococcus aureus alters growth activity, autolysis and antibiotic tolerance in a human host-adapted Pseudomonas aeruginosa lineage
Michelsen, C. F., Christensen, A. J., Bojer, Martin Saxtorph, Høiby, Niels, Ingmer, Hanne & Jelsbak, L., 2014, In: Journal of Bacteriology. 196, 22, p. 3903-3911 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation
Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Environmental Heterogeneity Drives Within-Host Diversification and Evolution of Pseudomonas aeruginosa
Markussen, T., Marvig, R. L., Gómez-Lozano, M., Aanæs, K., Burleigh, A. E., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., 2014, In: mBio. 5, 5, p. 1-10 10 p., e01592-14.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen
Kolpen, Mette, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Kolpen, Mette, Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: PLOS ONE. 9, 1, p. e84353 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples
Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo
Hengzhuang, W., Høiby, Niels & Ciofu, Oana, 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 239-54 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients
Kragh, K. N., Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In: Infection and Immunity. 82, 11, p. 4477-4486 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization
Knudsen, N. R., Rasmussen, A. K. I., Fiandaca, M. J., Kragh, K. N., Bjarnsholt, Thomas, Høiby, Niels, Stender, H. & Guardabassi, Luca, 2014, In: New Microbes and New Infections. 2, 3, p. 79-81 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis
Qvist, T., Pressler, T., Høiby, Niels & Katzenstein, T. L., 2014, In: Respiratory research. 15, p. 1-6 6 p., 41.Research output: Contribution to journal › Comment/debate › Research
- Published
Sinus biofilms in patients with cystic fibrosis: is adjusted eradication therapy needed?
Aanæs, Kasper, Eickhardt, S., Johansen, Helle Krogh, von Buchwald, Christian, Skov, M., Høiby, Niels & Bjarnsholt, Thomas, 2014, In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial biofilm formation and treatment in soft tissue fillers
Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.Research output: Contribution to journal › Journal article › Research
- Published
Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis
Dalbøge, C. S., Nielsen, X. C., Dalhoff, K., Alffenaar, J. W., Duno, M., Buchard, Anders, Uges, D. R. A., Jensen, A. G., Jürgens, G., Pressler, T., Johansen, H. K. & Høiby, Niels, Mar 2014, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 13, 2, p. 179-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A personal history of research on microbial biofilms and biofilm infections
Høiby, Niels, Apr 2014, In: Pathogens and Disease. 70, 3, p. 205-211 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Effects of Radix Ginseng on microbial infections: a narrative review
Wu, H., Høiby, Niels, Yang, L., Givskov, Michael & Song, Z., Apr 2014, In: Journal of Traditional Chinese Medicine. 34, 2, p. 227-233 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mariner transposon vector adapted for mutagenesis in oral streptococci
Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria - experiences from the Danish Cystic Fibrosis cohort study
Qvist, T., Johansen, I. S., Pressler, T., Høiby, Niels, Andersen, A. B., Katzenstein, T. L. & Bjerrum, S., 4 Dec 2014, In: BMC Infectious Diseases. 14, p. 1-8 8 p., 655.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model
Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In: The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”
Eickhardt-Dalbøge, S. R., Kragh, K. N., Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In: Pathogens and Disease. 73, 4, 4 p., ftv012.Research output: Contribution to journal › Letter › Research › peer-review
ID: 8427
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Research output: Contribution to journal › Journal article › Research › peer-review
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2838
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Research output: Contribution to journal › Journal article › Research › peer-review
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