Niels Høiby

Niels Høiby

Professor, No job title

Member of:


    1. Published

      Understanding biofilms - Are we there yet?

      Bjarnsholt, Thomas, Høiby, Niels, Donelli, G., Imbert, C. & Försberg, A., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 125-126 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.

      Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      [Debat]

      Bjerrum, Lars, Grinsted, P., Søgaard, P., Frimodt-Møller, N., Høiby, Niels & Tvede, M., 2002, In: Ugeskrift for Laeger. 164, 22, p. 2930-2932 3 p.

      Research output: Contribution to journalJournal articleResearch

    5. Published

      Rifampicin reduces plasma concentration of linezolid in patients with infective endocarditis

      Bock, M., Van Hasselt, J. G. C., Schwartz, F., Wang, H., Høiby, N., Fuursted, K., Ihlemann, N., Gill, S., Christiansen, U., Bruun, N. E., Elming, H., Povlsen, J. A., Køber, L., Høfsten, D. E., Fosbøl, E. L., Pries-Heje, M. M., Christensen, J. J., Rosenvinge, F. S., Torp-Pedersen, C., Helweg-Larsen, J. & 4 others, Tønder, N., Iversen, Kasper, Bundgård, Henning & Moser, Claus Ernst, 2023, In: The Journal of antimicrobial chemotherapy. 78, 12, p. 2840–2848 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Attainment of Target Antibiotic Levels by Oral Treatment of Left-sided Infective Endocarditis: A POET Substudy

      Bock, M., Theut, A. M., van Hasselt, J. G. C., Wang, H., Fuursted, K., Hoiby, N., Lerche, C. J., Ihlemann, N., Gill, S., Christiansen, U., Nielsen, H. L., Lemming, L., Elming, H., Povlsen, J. A., Bruun, N. E., Hofsten, D., Fosbøl, E. L., Kober, L., Schultz, M., Pries-Heje, M. M. & 9 others, Kristensen, J. H., Christensen, J. J., Rosenvinge, F. S., Torp-Pedersen, Christian, Helweg-Larsen, J., Tønder, N., Iversen, Kasper, Bundgård, Henning & Moser, Claus Ernst, 2023, In: Clinical Infectious Diseases. 77, 2, p. 242–251 10 p., 168.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection

      Bohn, Y. T., Brandes, G., Rakhimova, E., Horatzek, S., Salunkhe, P., Munder, A., van Barneveld, A., Jordan, D., Bredenbruch, F., Häussler, S., Riedel, K., Eberl, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, C., Høiby, Niels, Tümmler, B. & Wiehlmann, L., 2008, In: Molecular Microbiology. 71, 3, p. 730-47 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model

      Brinch, K. S., Sandberg, A., Baudoux, P., Van Bambeke, F., Tulkens, P. M., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 11, p. 4801-8 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin

      Brinch, K. S., Tulkens, P. M., Van Bambeke, F., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 1 Aug 2010, In: Journal of Antimicrobial Chemotherapy. 65, 8, p. 1720-4 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Influence of antidrug antibodies on plectasin efficacy and pharmacokinetics

      Brinch, K. S., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 11, p. 4794-800 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

      Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

      Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.

      Research output: Contribution to journalReviewResearchpeer-review

    13. Published

      Cytokine and surface receptor diversity of NK cells in resistant C3H/HeN and susceptible BALB/c mice with chronic Pseudomonas aeruginosa lung infection

      Calum, H., Moser, C., Jensen, P. Ø., Shirai, R. & Høiby, Niels, 2003, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 111, 9, p. 891-897 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Murine burn lesion model for studying acute and chronic wound infections

      Calum, Henrik Pierre, Trøstrup, H., Laulund, A. S., Thomsen, K., Christophersen, L., Høiby, Niels & Moser, Claus Ernst, 2022, In: APMIS. 130, 7, p. 477-490 14 p.

      Research output: Contribution to journalReviewResearchpeer-review

    15. Published

      Cytokine and surface receptor diversity of NK cells in resistant C3H/HeN and susceptible BALB/c mice with chronic Pseudomonas aeruginosa lung infection

      Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Shirai, R. & Høiby, Niels, Sep 2003, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 111, 9, p. 891-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection

      Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Christoffersen, L., Damlund, D. S. M., Alhede, M., Bjarnsholt, Thomas, Hougen, H. P., Givskov, Michael, Jacobsen, G. K. & Høiby, Niels, 2008, In: Clinical and Experimental Immunology. 156, 1, p. 102-110 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Early IL-2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN-dominating response and reduced lung pathology

      Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Bjarnsholt, Thomas, Givskov, Michael & Høiby, Niels, 2020, In: APMIS - Journal of Pathology, Microbiology and Immunology. 128, 12, p. 647-653

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

      Campbell, J. I., Ciofu, Oana & Høiby, Niels, 1997, In: Antimicrobial Agents and Chemotherapy. 41, 6, p. 1380-4 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model

      Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In: The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Diffusion retardation by binding of tobramycin in an alginate biofilm model

      Cao, B., Christophersen, L., Kolpen, Mette, Jensen, Peter Østrup, Sneppen, Kim, Høiby, Niels, Moser, Claus Ernst & Sams, T., 21 Apr 2016, In: P L o S One. 11, 4, 11 p., e0153616.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients

      Caçador, N. C., Paulino da Costa Capizzani, C., Monteiro Marin Torres, L. A. G., Galetti, R., Ciofu, Oana, Lúcia da Costa Darini, A. & Høiby, Niels, 2018, In: PLoS ONE. 13, 11, 11 p., e0208013.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

      Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Synergistic antimicrobial efficacy of furanone C30 and tobramycin against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

      Christensen, L., van Gennip, M., Alhede, M., Kumar, N., Kjelleberg, S., Høiby, Niels, Bjarnsholt, Thomas & Givskov, M., 2010. 0 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    24. Published

      Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

      Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model

      Hultqvist, Louise Dahl, Moser, C., Jensen, Peter Østrup, Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

      Christophersen, L. J., Trøstrup, H., Damlund, D. S. M., Bjarnsholt, Thomas, Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, 2012, In: Experimental and clinical endocrinology. 170, 2, p. 222-30 10 p., 170.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments

      Christophersen, L., Schwartz, F. A., Lerche, C. J., Svanekjær, T., Kragh, K. N., Laulund, A. S., Thomsen, K., Henneberg, K. Å., Sams, T., Høiby, Niels & Moser, Claus Ernst, 2020, In: Journal of Cystic Fibrosis. 19, 6, p. 996-1003

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Increased severity of chronic Pseuomonas aeruginosa biofilm infection in the smaller airways of BALB/C mice

      Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.

      Research output: Contribution to conferencePosterResearchpeer-review

    29. Published

      Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice exacerbates pulmonary inflammation.

      Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    30. Published

      Increased severity of chronic Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice

      Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    31. Published

      Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis.

      Ciofu, Oana, Petersen, T. D., Jensen, P. & Høiby, Niels, 1999, In: Thorax. 54, 2, p. 141-4 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.

      Ciofu, Oana, Beveridge, T. J., Kadurugamuwa, J., Walther-Rasmussen, J. & Høiby, Niels, 2000, In: Journal of Antimicrobial Chemotherapy. 45, 1, p. 9-13 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      The influence of allotypes on the IgG subclass response to chromosomal beta-lactamase of Pseudomonas aeruginosa in cystic fibrosis patients.

      Ciofu, Oana, Pressler, T., Pandey, J. P. & Høiby, Niels, 1997, In: Clinical and Experimental Immunology. 108, 1, p. 88-94 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, beta-lactamase activity and RiboPrinting.

      Ciofu, Oana, Fussing, V., Bagge, N., Koch, C. & Høiby, Niels, 2001, In: Journal of Antimicrobial Chemotherapy. 48, 3, p. 391-6 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Development of antibiotic resistance in Pseudomonas aeruginosa during two decades of antipseudomonal treatment at the Danish CF Center.

      Ciofu, Oana, Giwercman, B., Pedersen, S. S. & Høiby, Niels, 1994, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 102, 9, p. 674-80 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams.

      Ciofu, Oana, Giwercman, B., Walter-Rasmussen, J., Pressler, T., Pedersen, S. S. & Høiby, Niels, 1995, In: Journal of Antimicrobial Chemotherapy. 35, 2, p. 295-304 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Cystic fibrosis: coping with resistance

      Ciofu, Oana, Høiby, Niels, Gould, I. M. & Meer, J. W. M. V. D., 2007, Antibiotic policies: fighting resistance. Springer, p. 149-174 25 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    38. Published

      Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants.

      Ciofu, Oana, Lee, B., Johannesson, M., Hermansen, N. O., Meyer, P., Høiby, Niels & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 2008, In: Microbiology. 154, Pt 1, p. 103-13 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

      Ciofu, Oana, Mandsberg, L. F., Bjarnsholt, Thomas, Wassermann, T. & Høiby, Niels, 2010, In: Microbiology. 156, p. 1108-1119 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Antibodies against beta-lactamase can improve ceftazidime treatment of lung infection with beta-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection.

      Ciofu, Oana, Bagge, N. & Høiby, Niels, 2002, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 110, 12, p. 881-91 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Respiratory bacterial infections in cystic fibrosis

      Ciofu, Oana, Hansen, C. R. & Høiby, Niels, May 2013, In: Current Opinion in Pulmonary Medicine. 19, 3, p. 251-8 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Gene transcription profiles of paired mucoid and non-mucoid P. aeruginosa isolates from sinuses and lungs of patients with cystic fibrosis

      Ciofu, O., Johansen, Helle Krogh, Wassermann, T., Aanæs, Kasper, Alhede, M. & Høiby, Niels, 23 May 2010. 0 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    43. Published

      Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.

      Ciofu, Oana, Riis, B., Pressler, T., Poulsen, Henrik Enghusen & Høiby, Niels, 2005, In: Antimicrobial Agents and Chemotherapy. 49, 6, p. 2276-82 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Meropenem in cystic fibrosis patients infected with resistant Pseudomonas aeruginosa or Burkholderia cepacia and with hypersensitivity to beta-lactam antibiotics.

      Ciofu, Oana, Jensen, T., Pressler, T., Johansen, Helle Krogh, Bender Koch, Christian & Høiby, Niels, 1996, In: Clinical Microbiology and Infection. 2, 2, p. 91-98 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

      Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.

      Research output: Contribution to journalReviewResearchpeer-review

    46. Published

      Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections

      Ciofu, Oana, Mandsberg, L. F., Wang, H. & Høiby, Niels, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

      Ciofu, Oana, Johansen, Helle Krogh, Aanæs, Kasper, Wassermann, T., Alhede, M., von Buchwald, Christian & Høiby, Niels, 8 Mar 2013, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12, 6, p. 729-736 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Tolerance and resistance of microbial biofilms

      Ciofu, Oana, Moser, Claus Ernst, Jensen, Peter Østrup & Høiby, Niels, 2022, In: Nature Reviews Microbiology. 20, p. 621–635

      Research output: Contribution to journalReviewResearchpeer-review

    49. Published

      Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and control

      Collins, M. T., Lisby, G., Moser, C., Chicks, D., Christensen, S., Reichelderfer, M., Høiby, Niels, Harms, B., Thomsen, O. Ø., Skibsted, U. & Binder, V., 2000, In: Journal of Clinical Microbiology. 38, p. 4373-4381

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis

      Cramer, N., Wiehlmann, L., Ciofu, Oana, Tamm, S., Høiby, Niels & Tümmler, B., Nov 2012, In: PLOS ONE. 7, 11, e50731.

      Research output: Contribution to journalJournal articleResearchpeer-review

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