Oana Ciofu

Oana Ciofu

Professor

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    ORCID: 0000-0001-5648-4858

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    1. Published

      The evolutionary trajectories of P. aeruginosa in biofilm and planktonic growth modes exposed to ciprofloxacin: beyond selection of antibiotic resistance

      Ahmed, M. N., Abdelsamad, A., Wassermann, T., Porse, A., Becker, J., Sommer, M. O. A., Høiby, Niels & Ciofu, Oana, 2020, In: npj Biofilms and Microbiomes. 6, 1, 10 p., 28.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms

      Ahmed, M. N., Porse, A., Abdelsamad, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 2019, In: Antimicrobial Agents and Chemotherapy. 63, 10, 12 p., e00766-19.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin

      Ahmed, M. N. A., Porse, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 1 Aug 2018, In: Antimicrobial Agents and Chemotherapy. 62, 8, 12 p., e00320-18.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

      Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Rapid development in vitro and in vivo of resistance to ceftazidime in biofilm-growing Pseudomonas aeruginosa due to chromosomal beta-lactamase

      Bagge, N., Ciofu, Oana, Skovgaard, Lene Theil & Høiby, Niels, Sep 2000, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 108, 9, p. 589-600 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.

      Bagge, N., Ciofu, Oana, Hentzer, M., Campbell, J. I. A., Givskov, Michael & Høiby, Niels, 2002, In: Antimicrobial Agents and Chemotherapy. 46, 11, p. 3406-11 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.

      Bagge, N., Hentzer, M., Andersen, Jens Bo, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1168-74 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

      Bagge, N., Schuster, M., Hentzer, M., Ciofu, Oana, Givskov, Michael, Greenberg, E. P. & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1175-87 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Applying insights from biofilm biology to drug development - can a new approach be developed?

      Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

      Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

      Campbell, J. I., Ciofu, Oana & Høiby, Niels, 1997, In: Antimicrobial Agents and Chemotherapy. 41, 6, p. 1380-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients

      Caçador, N. C., Paulino da Costa Capizzani, C., Monteiro Marin Torres, L. A. G., Galetti, R., Ciofu, Oana, Lúcia da Costa Darini, A. & Høiby, Niels, 2018, In: PLoS ONE. 13, 11, 11 p., e0208013.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis.

      Ciofu, Oana, Petersen, T. D., Jensen, P. & Høiby, Niels, 1999, In: Thorax. 54, 2, p. 141-4 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.

      Ciofu, Oana, Beveridge, T. J., Kadurugamuwa, J., Walther-Rasmussen, J. & Høiby, Niels, 2000, In: Journal of Antimicrobial Chemotherapy. 45, 1, p. 9-13 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The influence of allotypes on the IgG subclass response to chromosomal beta-lactamase of Pseudomonas aeruginosa in cystic fibrosis patients.

      Ciofu, Oana, Pressler, T., Pandey, J. P. & Høiby, Niels, 1997, In: Clinical and Experimental Immunology. 108, 1, p. 88-94 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, beta-lactamase activity and RiboPrinting.

      Ciofu, Oana, Fussing, V., Bagge, N., Koch, C. & Høiby, Niels, 2001, In: Journal of Antimicrobial Chemotherapy. 48, 3, p. 391-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Development of antibiotic resistance in Pseudomonas aeruginosa during two decades of antipseudomonal treatment at the Danish CF Center.

      Ciofu, Oana, Giwercman, B., Pedersen, S. S. & Høiby, Niels, 1994, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 102, 9, p. 674-80 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams.

      Ciofu, Oana, Giwercman, B., Walter-Rasmussen, J., Pressler, T., Pedersen, S. S. & Høiby, Niels, 1995, In: Journal of Antimicrobial Chemotherapy. 35, 2, p. 295-304 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Cystic fibrosis: coping with resistance

      Ciofu, Oana, Høiby, Niels, Gould, I. M. & Meer, J. W. M. V. D., 2007, Antibiotic policies: fighting resistance. Springer, p. 149-174 25 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    21. Published

      Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants.

      Ciofu, Oana, Lee, B., Johannesson, M., Hermansen, N. O., Meyer, P., Høiby, Niels & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 2008, In: Microbiology. 154, Pt 1, p. 103-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Antibiotic treatment of biofilm infections

      Ciofu, Oana, Rojo-Molinero, E., Macià, M. D. & Oliver, A., Apr 2017, In: APMIS. 125, 4, p. 304-319 16 p.

      Research output: Contribution to journal › Review › Research › peer-review

    23. Published

      Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

      Ciofu, Oana, Mandsberg, L. F., Bjarnsholt, Thomas, Wassermann, T. & Høiby, Niels, 2010, In: Microbiology. 156, p. 1108-1119 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Antibodies against beta-lactamase can improve ceftazidime treatment of lung infection with beta-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection.

      Ciofu, Oana, Bagge, N. & Høiby, Niels, 2002, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 110, 12, p. 881-91 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Respiratory bacterial infections in cystic fibrosis

      Ciofu, Oana, Hansen, C. R. & Høiby, Niels, May 2013, In: Current Opinion in Pulmonary Medicine. 19, 3, p. 251-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Antibiotic tolerance and resistance in biofilms.

      Ciofu, Oana & Tolker-Nielsen, Tim, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C., Jensen, P. Ø. & Høiby, N. (eds.). New York, USA: Springer Publishing Company, p. 215-230 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    27. Published

      Chronic Infection with Pseudomonas aeruginosa in an animal model of oxidative stress: lessons for patients with cystic fibrosis

      Ciofu, Oana, 2015, Diet and Exercise in Cystic Fibrosis. Ross Watson, R. (ed.). London: Academic Press, p. 171-176

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    28. Published

      Antioxidant supplementation for lung disease in cystic fibrosis

      Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2019, In: Cochrane Database of Systematic Reviews. 2019, 10, CD007020.

      Research output: Contribution to journal › Review › Research › peer-review

    29. Published

      Pseudomonas aeruginosa chromosomal beta-lactamase in patients with cystic fibrosis and chronic lung infection. Mechanism of antibiotic resistance and target of the humoral immune response.

      Ciofu, Oana, 2003, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 116, p. 1-47 46 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.

      Ciofu, Oana, Riis, B., Pressler, T., Poulsen, Henrik Enghusen & Høiby, Niels, 2005, In: Antimicrobial Agents and Chemotherapy. 49, 6, p. 2276-82 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Antibiotic tolerance and resistance in biofilms

      Ciofu, Oana & Tolker-Nielsen, Tim, 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    32. Published

      Tolerance and resistance of pseudomonas aeruginosabiofilms to antimicrobial agents-how P. aeruginosa Can escape antibiotics

      Ciofu, Oana & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 10, MAY, 15 p., 913.

      Research output: Contribution to journal › Review › Research › peer-review

    33. Published

      Meropenem in cystic fibrosis patients infected with resistant Pseudomonas aeruginosa or Burkholderia cepacia and with hypersensitivity to beta-lactam antibiotics.

      Ciofu, Oana, Jensen, T., Pressler, T., Johansen, Helle Krogh, Bender Koch, Christian & Høiby, Niels, 1996, In: Clinical Microbiology and Infection. 2, 2, p. 91-98 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      A systematic Cochrane Review of antioxidant supplementation lung disease for cystic fibrosis

      Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2020, In: Paediatric Respiratory Reviews. 33, p. 28-29

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    35. Published

      Antioxidant supplementation for lung disease in cystic fibrosis

      Ciofu, Oana & Lykkesfeldt, Jens, 2014, In: The Cochrane library. 2014, 8, 87 p., CD007020.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

      Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    37. Published

      Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections

      Ciofu, Oana, Mandsberg, L. F., Wang, H. & Høiby, Niels, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

      Ciofu, Oana, Johansen, Helle Krogh, Aanæs, Kasper, Wassermann, T., Alhede, M., von Buchwald, Christian & Høiby, Niels, 8 Mar 2013, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12, 6, p. 729-736 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Tolerance and resistance of microbial biofilms

      Ciofu, Oana, Moser, Claus Ernst, Jensen, Peter Østrup & Høiby, Niels, 2022, In: Nature Reviews Microbiology. 20, p. 621–635

      Research output: Contribution to journal › Review › Research › peer-review

    40. Published

      Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis

      Cramer, N., Wiehlmann, L., Ciofu, Oana, Tamm, S., Høiby, Niels & Tümmler, B., Nov 2012, In: PLOS ONE. 7, 11, e50731.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

      Fernandez-Barat, L., Ciofu, Oana, Kragh, K. N., Pressler, T., Johansen, U., Motos, A., Torres, A. & Høiby, Niels, Mar 2017, In: Journal of Cystic Fibrosis. 16, 2, p. 222-229

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Typing of Pseudomonas aeruginosa strains in Norwegian cystic fibrosis patients.

      Fluge, G., Ojeniyi, B., Høiby, Niels, Digranes, A., Ciofu, Oana, Hunstad, E., Haanaes, O. C. & Storrøsten, O. T., 2001, In: Clinical Microbiology and Infection. 7, 5, p. 238-43 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

      Folkesson, A., Jelsbak, L., Yang, L., Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels & Molin, S., Dec 2012, In: Nature Reviews. Microbiology. 10, 12, p. 841-851 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Antibodies against chromosomal beta-lactamase.

      Giwercman, B., Rasmussen, J. W., Ciofu, Oana, Clemmentsen, I., Schumacher, H. & Høiby, Niels, 1994, In: Antimicrobial Agents and Chemotherapy. 38, 10, p. 2306-10 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection

      Hansen, S. K., Rau, M. H., Johansen, Helle Krogh, Ciofu, Oana, Jelsbak, L., Yang, L., Folkesson, A., Jarmer, H. Ø., Aanæs, Kasper, von Buchwald, Christian, Høiby, Niels & Molin, S., 2012, In: I S M E Journal. 6, 1, p. 31-45

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Cellular responses of A549 alveolar epithelial cells to serially collected Pseudomonas aeruginosa from cystic fibrosis patients at different stages of pulmonary infection

      Hawdon, N. A., Aval, P. S., Barnes, R. J., Gravelle, S. K., Rosengren, J., Khan, S., Ciofu, Oana, Johansen, Helle Krogh, Høiby, Niels & Ulanova, M., 1 Jul 2010, In: FEMS Immunology and Medical Microbiology. 59, 2, p. 207-20 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms

      Hengzhuang, W., Ciofu, Oana, Yang, L., Wu, H., Song, Z., Oliver, A. & Høiby, Niels, Jan 2013, In: Antimicrobial Agents and Chemotherapy. 57, 1, p. 196-204 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo

      Hengzhuang, W., Høiby, Niels & Ciofu, Oana, 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 239-54 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z., Høiby, Niels & Wang, H., Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, 1 Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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