Thomas Eiland Nielsen

Thomas Eiland Nielsen

Affiliate Professor


Publication year:
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1 - 25 out of 27Page size: 25
  1. 2022
  2. Published

    Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

    Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2021
  4. Published

    Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

    Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

    Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2019
  7. Published

    Generation of a Heteropolycyclic and sp3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence

    Flagstad, T., Azevedo, C. M. G., Troelsen, N. S., Min, G. K., Macé, Y., Willaume, A., Guilleux, R., Velay, M., Bonnet, K., Morgentin, R., Nielsen, Thomas Eiland & Clausen, M. H., 2019, In: European Journal of Organic Chemistry. 2019, 5, p. 1061-1076

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

    Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Reactivity and Synthetic Applications of Multicomponent Petasis Reactions

    Wu, P., Givskov, Michael & Nielsen, Thomas Eiland, 2019, In: Chemical Reviews. 119, 20, p. 11245-11290 46 p.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

    Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

    Research output: Contribution to journal › Review › Research › peer-review

  11. 2018
  12. Published

    Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

    Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Liu, X., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Bead-based screening in chemical biology and drug discovery

    Komnatnyy, V. V., Nielsen, Thomas Eiland & Qvortrup, K., 2018, In: Chemical Communications. 54, 50, p. 6759-6771 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Oxidative Modification of Tryptophan-Containing Peptides

    Petersen, Jonas Odgaard, Christensen, K. E., Nielsen, M. T., Mortensen, K. T., Komnatnyy, V. V., Nielsen, Thomas Eiland & Qvortrup, K., 2018, In: ACS Combinatorial Science. 20, 6, p. 344-349 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds

    Wu, P. & Nielsen, Thomas Eiland, 2018, In: Drug Discovery Today: Technologies. 29, p. 27-33

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Petasis/Diels–Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production

    Flagstad, T., Azevedo, C. M. G., Min, G., Willaume, A., Morgentin, R., Nielsen, Thomas Eiland & Clausen, M. H., 2018, In: European Journal of Organic Chemistry. 2018, 36, p. 5023-5029 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Photolabile Linkers for Solid-Phase Synthesis

    Mikkelsen, R. J. T., Grier, K. E., Mortensen, K. T., Nielsen, Thomas Eiland & Qvortrup, K., 2018, In: ACS Combinatorial Science. 20, 7, p. 377-379 3 p.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

    Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Hoong Yam, J. K., Aung, T. T., Beuerman, R. W., Santillan Salido, M. M., Schuster, S. C., Tan, C. H., Givskov, Michael, Yang, L. & Nielsen, Thomas Eiland, 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 3059-3069 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2017
  20. Published

    A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

    Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

    Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    A broad range quorum sensing inhibitor working through sRNA inhibition

    Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists

    Palmer, D., Gonçalves, J. P. L., Hansen, L. V., Wu, B., Hald, H., Schoffelen, S., Diness, Frederik, Le Quement, S. T., Nielsen, Thomas Eiland & Meldal, Morten Peter, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8716-8730 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions

    Ishoey, M., Petersen, R. G., Petersen, M. A., Wu, P., Clausen, M. H. & Nielsen, Thomas Eiland, 2017, In: Chemical Communications. 53, 68, p. 9410-9413

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Kinase Inhibitors

    Wu, P., Givskov, Michael & Nielsen, Thomas Eiland, 2017, Drug Selectivity: An Evolving Concept in Medicinal Chemistry. Wiley-Interscience, p. 33-53 21 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  26. Published

    Scaffold Diversity from N-Acyliminium Ions

    Wu, P. & Nielsen, Thomas Eiland, 2017, In: Chemical Reviews. 117, 12, p. 7811-7856 46 p.

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing

    Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Wu, B., Su, H. & Yang, L., 2017, bioRxiv, 27 p.

    Research output: Working paper › Preprint › Research

  28. 2016
  29. Published

    The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

    Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2015
  31. Published

    In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

    Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2014
  33. Published

    Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics

    Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, Thomas Eiland, 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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