Tim Tolker-Nielsen
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N
Member of:
- Published
Inoculation method could impact the outcome of microbiological experiments
Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections
Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump
Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualizing biofilm by targeting eDNA with long wavelength probe CDr15
Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CDy14: A novel biofilm probe targeting exopolysaccharide Psl
Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells.
Lange, M., Tolker-Nielsen, Tim, Molin, S. & Ahring, B. K., 2000, In: Applied and Environmental Microbiology. 66, 5, p. 1796-800 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa.
Li, Y., Xia, H., Bai, F., Xu, H., Yang, L., Yao, H., Zhang, L., Zhang, X., Bai, Y., Saris, P. E. J., Tolker-Nielsen, Tim & Qiao, M., 2007, In: FEMS Microbiology Letters. 272, 2, p. 188-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP
Liang, Z., Rybtke, Morten Levin, Kragh, K. N., Johnson, O., Schicketanz, Muriel Leandra, Zhang, Yong, Andersen, Jens Bo & Tolker-Nielsen, Tim, 2022, In: Microbiology Spectrum. 10, 4, 13 p., e00675-22.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of individual exopolysaccharides in antibiotic tolerance of Pseudomonas aeruginosa aggregates
Liang, Z., Nilsson, M., Kragh, K. N., Hedal, I., Alcàcer-Almansa, J., Kiilerich, R. O., Andersen, Jens Bo & Tolker-Nielsen, Tim, 2023, In: Frontiers in Microbiology. 14, 1187708.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.
Licht, T. R., Tolker-Nielsen, Tim, Holmstrøm, K., Krogfelt, K. & Molin, S., 1999, In: Environmental Microbiology. 1, 1, p. 23-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa
Lichtenberg, Mads, Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2022, In: Cell Reports. 41, 3, p. 111515 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa
Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Redox protein osar (pa0056) regulates dsbm and the oxidative stress response in pseudomonas aeruginosa
Liu, Y., Ma, Y., Ma, Z., Han, X., Qi, H., Andersen, Jens Bo, Xu, H., Tolker-Nielsen, Tim & Qiao, M., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 3, e01771-20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacteria can form interconnected microcolonies when a self-excreted product reduces their surface motility: evidence from individual-based model simulations
Mabrouk, N., Deffuant, G., Tolker-Nielsen, Tim & Lobry, C., 2010, In: Theory in Biosciences. 129, 1, p. 1-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genetic switch controls Pseudomonas aeruginosa surface colonization
Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia
McCarthy, Y., Yang, L., Twomey, K. B., Sass, A., Tolker-Nielsen, Tim, Mahenthiralingam, E., Dow, J. M. & Ryan, R. P., 2010, In: Molecular Microbiology. 77, 5, p. 1220-1236 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pseudomonas aeruginosa: A Model for Biofilm Formation
McDougald, D., Klebensberger, J., Tolker-Nielsen, Tim, Webb, J. S., Conibear, T., Rice, S. A., Kirov, S. M., Matz, C. & Kjelleberg, S., 2008, Pseudomonas. Model Organism, Pathogen, Cell Factory.. Rehm, B. H. A. (ed.). Wiley-VCH, p. 215-254 40 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
In silico analyses of metagenomes from human atherosclerotic plaque samples
Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.Research output: Contribution to journal › Journal article › Research › peer-review
Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure.
Molin, S. & Tolker-Nielsen, Tim, 2003, In: Current Opinion in Biotechnology. 14, 3, p. 255-61 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular ecology of biofilms.
Molin, S., Nielsen, A. T., Christensen, B. B., Andersen, J. B., Licht, T. R., Tolker-Nielsen, Tim, Sternberg, C., Hansen, M. C., Ramos, C. & Givskov, M., 2000, Biofilms.. Wiley, p. 89-120Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Microbial interactions in mixed-species biofilms.
Molin, S., Tolker-Nielsen, Tim & Hansen, S. K., 2004, Microbial biofilms.. Ghannoum, M. & O’Toole, G. A. (eds.). ASM International, p. 206-221Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Immune Responses to Pseudomonas aeruginosa Biofilm Infections
Moser, Claus Ernst, Jensen, Peter Østrup, Thomsen, K., Kolpen, M., Rybtke, Morten Levin, Lauland, A. S., Trøstrup, H. & Tolker-Nielsen, Tim, 2021, In: Frontiers in Immunology. 12, 625597.Research output: Contribution to journal › Review › Research › peer-review
- Published
Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.Research output: Contribution to journal › Journal article › Research › peer-review
Role of commensal relationships on the spatial structure of a surface-attached microbial consortium.
Nielsen, A. T., Tolker-Nielsen, Tim, Barken, K. B. & Molin, S., 2000, In: Environmental Microbiology. 2, 1, p. 59-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark
Nielsen, K. L., Hammerum, A. M., Lambertsen, L. M., Lester, C. H., Arpi, M., Knudsen, J. D., Stegger, M., Tolker-Nielsen, Tim & Frimodt-Møller, N., 2010, In: Scandinavian Journal of Infectious Diseases. 42, 8, p. 586-93 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms
Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In: International Journal of Antimicrobial Agents. 48, 3, p. 298–304Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability
Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance
Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mariner transposon vector adapted for mutagenesis in oral streptococci
Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms
Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transposon Mutagenesis in Streptococcus Species
Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, 2019, Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, p. 39-49 11 p. (Methods in Molecular Biology, Vol. 2016).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation
Okshevsky, M., Louw, M. G., Lamela, E. O., Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim & Meyer, R. L., 2018, In: MicrobiologyOpen. 7, 2, 17 p., e00552.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress
Orlandi, V. T., Bolognese, F., Chiodaroli, L., Tolker-Nielsen, Tim & Barbieri, P., Dec 2015, In: Microbiology. 161, 12, p. 2298-309 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1
Orlandi, V. T., Rybtke, Morten Levin, Caruso, E., Banfi, S., Tolker-Nielsen, Tim & Barbieri, P., Sep 2014, In: Biofouling. 30, 8, p. 883-91 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The biofilm matrix - A sticky framework.
Pamp, S., Gjermansen, M. & Tolker-Nielsen, Tim, 2007, The biofilm mode of life - Mechanisms and adaptations.. Kjelleberg, S. & Givskov, M. (eds.). HorizonBioscience, p. 37-69Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes
Pamp, S. J., Gjermansen, M., Johansen, Helle Krogh & Tolker-Nielsen, Tim, 2008, In: Molecular Microbiology. 68, 1, p. 223-40 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.
Pamp, S. J. & Tolker-Nielsen, Tim, 2007, In: Journal of Bacteriology. 189, 6, p. 2531-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy
Pamp, S. J., Sternberg, C. & Tolker-Nielsen, Tim, 2009, In: Cytometry. Part A. 75, 2, p. 90-103 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pattern formation in Pseudomonas aeruginosa biofilms.
Parsek, M. R. & Tolker-Nielsen, Tim, 2008, In: Current Opinion in Microbiology. 11, p. 560-566 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Microbial motility involvement in biofilm structure formation--a 3D modelling study.
Picioreanu, C., Kreft, J. U., Klausen, M., Haagensen, J. A. J., Tolker-Nielsen, Tim & Molin, S., 2007, In: Water Science and Technology. 55, 8-9, p. 337-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa
Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis
Qin, Z., Yang, L., Qu, D., Molin, S. & Tolker-Nielsen, Tim, 2009, In: Microbiology. 155, Pt 7, p. 2148-56 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.
Qin, Z., Ou, Y., Yang, L., Zhu, Y., Tolker-Nielsen, Tim, Molin, S. & Qu, D., 2007, In: Microbiology. 153, Pt 7, p. 2083-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation
Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.Research output: Contribution to journal › Review › Research › peer-review
Microbial pathogenesis and biofilm development.
Reisner, A., Høiby, N., Tolker-Nielsen, Tim & Molin, S., 2005, In: Contributions to Microbiology. 12, p. 114-31 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia
Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa
Ring, H. C., Bay, Lene, Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000Research output: Contribution to journal › Journal article › Research › peer-review
Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.
Ryan, R. P., Fouhy, Y., Garcia, B. F., Watt, S. A., Niehaus, K., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2008, In: Molecular Microbiology. 68, 1, p. 75-86 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
When the PilZ don't work: effectors for cyclic di-GMP action in bacteria
Ryan, R. P., Tolker-Nielsen, Tim & Dow, J. M., May 2012, In: Current Trends in Microbiology. 20, 5, p. 235-242 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa
Ryan, R. P., Lucey, J., O'Donovan, K., McCarthy, Y., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2009, In: Environmental Microbiology. 11, 5, p. 1126-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface
Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In: MicrobiologyOpen. 4, 6, p. 917-930 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response
Rybtke, Morten Levin, Hultqvist, Louise Dahl, Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645Research output: Contribution to journal › Review › Research › peer-review
- Published
The Extracellular Polysaccharide Matrix of Pseudomonas aeruginosa Biofilms Is a Determinant of Polymorphonuclear Leukocyte Responses
Rybtke, Morten Levin, Jensen, Peter Østrup, Nielsen, Claus Henrik & Tolker-Nielsen, Tim, 2021, In: Infection and Immunity. 89, 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gauging and visualizing c-di-GMP levels in pseudomonas aeruginosa using fluorescence-based biosensors
Rybtke, Morten Levin, Chua, S. L., Yam, J. K. H., Givskov, Michael, Yang, L. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 87-98 12 p. (Methods in Molecular Biology, Vol. 1657).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The implication of Pseudomonas aeruginosa biofilms in infections
Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa.
Rybtke, Morten Levin, Borlee, B. R., Murakami, K., Irie, Y., Hentzer, M., Nielsen, T. E., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, 2012, In: Applied and Environmental Microbiology. 78, 15, p. 5060-5069 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilms can act as plasmid reserves in the absence of plasmid specific selection
Røder, Henriette Lyng, Trivedi, Urvish, Russel, J., Kragh, K. N., Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: npj Biofilms and Microbiomes. 7, 6 p., 78.Research output: Contribution to journal › Letter › Research › peer-review
- Published
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111
Schmid, N., Suppiger, A., Steiner, E., Pessi, G., Kaever, V., Fazli, M., Tolker-Nielsen, Tim, Jenal, U. & Eberl, L., 1 May 2017, In: Microbiology. 163, 5, p. 754-764 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions
Schwarz, S., West, T. E., Boyer, F., Chiang, W., Carl, M. A., Hood, R. D., Rohmer, L., Tolker-Nielsen, Tim, Skerrett, S. J. & Mougous, J. D., 2010, In: PLoS Pathogens. 6, 8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The contribution of cell-cell signaling and motility to bacterial biofilm formation
Shrout, J. D., Tolker-Nielsen, Tim, Givskov, Michael & Parsek, M. R., May 2011, In: M R S Bulletin. 36, 5, p. 367-373 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa
Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of LasR ligands through a virtual screening approach
Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit
Soh, E., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Camara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, bioRxiv, 43 p.Research output: Working paper › Preprint › Research
- Published
Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit
Soh, E. Y. C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Cámara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, In: PLOS Pathogens. 17, 8, 25 p., e1009425.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators
Stacy, D. M., Le Quement, S. T., Hansen, C., Clausen, J. W., Tolker-Nielsen, Tim, Brummond, J. W., Givskov, Michael, Nielsen, T. E. & Blackwell, H. E., 2013, In: Organic & Biomolecular Chemistry. 11, 6, p. 938-54 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The BDSF quorum sensing receptor RpfR regulates Bep exopolysaccharide synthesis in Burkholderia cenocepacia via interaction with the transcriptional regulator BerB
Steiner, E., Shilling, R. E., Richter, A. M., Schmid, N., Fazli, M., Kaever, V., Jenal, U., Tolker-Nielsen, Tim & Eberl, L., 2022, In: npj Biofilms and Microbiomes. 8, 93.Research output: Contribution to journal › Journal article › Research › peer-review
Growing and analyzing biofilms in flow cells.
Sternberg, C. & Tolker-Nielsen, Tim, 2006, In: Current Protocols in Microbiology. Chapter 1, p. Unit 1B.2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli
Sun, J., Marais, J. P. J., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, Michael, Tolker-Nielsen, Tim, Seeram, N. P. & Rowley, D. C., Aug 2015, In: Journal of Functional Foods. 17, p. 235-242 8 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa
Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82
Tay, M., Roizman, D., Cohen, Y., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Genome Announcements. 2, 1, p. 1 1 p., e01161-13.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells
Teh, W. K., Dramsi, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species
Thorsing, M., Bentin, Thomas, Givskov, Michael, Tolker-Nielsen, Tim & Goltermann, Lise, Oct 2015, In: Microbiology. 161, 10, p. 1999-2007 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Non-genetic population heterogeneity studied by in situ polymerase chain reaction.
Tolker-Nielsen, Tim, Holmstrøm, K., Boe, L. & Molin, S., 1998, In: Molecular Microbiology. 27, 6, p. 1099-105 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Visualization of specific gene expression in individual Salmonella typhimurium cells by in situ PCR.
Tolker-Nielsen, Tim, Holmstrøm, K. & Molin, S., 1997, In: Applied and Environmental Microbiology. 63, 11, p. 4196-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
The biofilm lifestyle of pseudomonads.
Tolker-Nielsen, Tim & Molin, S., 2004, Pseudomonas. Ramos, J. (ed.). Kluwer Academic Publishers, p. 547-571Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium.
Tolker-Nielsen, Tim & Molin, S., 1996, In: FEMS Microbiology Letters. 142, 2-3, p. 155-60 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effects of stress treatments on the detection of Salmonella typhimurium by in situ hybridization.
Tolker-Nielsen, Tim, Larsen, M. H., Kyed, H. & Molin, S., 1997, In: International Journal of Food Microbiology. 35, 3, p. 251-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa biofilm infections: From molecular biofilm biology to new treatment possibilities
Tolker-Nielsen, Tim, Dec 2014, 51 p. (APMIS Supplementum).Research output: Book/Report › Doctoral thesis › Research
- Published
Biofilm development
Tolker-Nielsen, Tim, 2015, Microbial biofilms. Ghannoum, M., Parsek, M., Whiteley, M. & P. M. (eds.). 2 ed. Washington DC: ASM Press, p. 51-66 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Spatial Organization of Microbial Biofilm Communities.
Tolker-Nielsen, Tim & Molin, S., 2000, In: Microbial Ecology. 40, 2, p. 75-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm development
Tolker-Nielsen, Tim, 1 Jan 2015, Microbial Biofilms. Wiley-Interscience, p. 51-66 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Biofilm development by pseudomonads.
Tolker-Nielsen, Tim & Molin, S., 2004, Environmental Biotechnology. Verstraete, W. (ed.). CRC Press/Balkema, p. 27-32Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Methods for studying biofilm formation: flow cells and confocal laser scanning microscopy
Tolker-Nielsen, Tim & Sternberg, C., 2014, In: Methods in Molecular Biology. 1149, p. 615-29 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilm Development
Tolker-Nielsen, Tim, Mar 2015, In: Microbiology Spectrum. 3, 2, 12 p., MB-0001-2014.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy
Tolker-Nielsen, Tim & Høiby, Niels, 2009, In: Future Microbiology. 4, p. 645-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and dynamics of Pseudomonas sp. biofilms.
Tolker-Nielsen, Tim, Brinch, U. C., Ragas, P. C., Andersen, J. B., Jacobsen, C. S. & Molin, S., 2000, In: Journal of Bacteriology. 182, 22, p. 6482-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.
Tolker-Nielsen, Tim & Boe, L., 1994, In: Journal of Bacteriology. 176, 14, p. 4306-10 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growing and analyzing biofilms in flow chambers
Tolker-Nielsen, Tim & Sternberg, C., 2011, In: Current Protocols in Microbiology. 21, p. 1B.2.1-1B.2.17Research output: Contribution to journal › Journal article › Research › peer-review
Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells.
Tolker-Nielsen, Tim, Christensen, A. B., Holmstrøm, K., Eberl, L., Rasmussen, T. B., Sternberg, C., Heydorn, A., Molin, S. & Givskov, M., 2000, In: Journal of Bacteriology. 182, 10, p. 2680-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier
Tran, C. S., Rangel, S. M., Almblad, H., Kierbel, A., Givskov, Michael, Tolker-Nielsen, Tim, Hauser, A. R. & Engel, J. N., Nov 2014, In: P L o S Pathogens. 10, 11, p. 1-11 12 p., e1004479.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes
Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene, encoding a nitronate monooxygenase
Vercammen, K., Wei, Q., Charlier, D., Dötsch, A., Haüssler, S., Schulz, S., Salvi, F., Gadda, G., Spain, J., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Dingemans, J., Ye, L. & Cornelis, P., Mar 2015, In: Journal of Bacteriology. 197, 6, p. 1026-39 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells
Wang, V. B., Chua, S., Cao, B., Seviour, T., Nesatyy, V. J., Marsili, E., Kjelleberg, S., Givskov, Michael, Tolker-Nielsen, Tim, Song, H., Loo, J. S. C. & Yang, L., 2013, In: PLOS ONE. 8, 5, p. e63129 7 p., e63129.Research output: Contribution to journal › Journal article › Research › peer-review
Cell death in Pseudomonas aeruginosa biofilm development.
Webb, J. S., Thompson, L. S., James, S., Charlton, T., Tolker-Nielsen, Tim, Koch, B., Givskov, M. & Kjelleberg, S., 2003, In: Journal of Bacteriology. 185, 15, p. 4585-92 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.
Whitchurch, C. B., Beatson, S. A., Comolli, J. C., Jakobsen, T., Sargent, J. L., Bertrand, J. J., West, J., Klausen, M., Waite, L. L., Kang, P. J., Tolker-Nielsen, Tim, Mattick, J. S. & Engel, J. N., 2005, In: Molecular Microbiology. 55, 5, p. 1357-78 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Extracellular DNA required for bacterial biofilm formation.
Whitchurch, C. B., Tolker-Nielsen, Tim, Ragas, P. C. & Mattick, J. S., 2002, In: Science. 295, 5559, p. 1487Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo
Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, Morten Levin, Seliktar, D., Kofidis, T., Høiby, Niels, Tolker-Nielsen, Tim, Song, Z. & Givskov, Michael, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa
Yam, J. K. H., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Salido, M. M. S., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Boo, Z. Z., Wu, B., Kjelleberg, S., Tolker-Nielsen, T., Lakshminarayanan, R., Beuerman, R. W., Yang, L. & 1 others, , 2022, In: Infection and Immunity. 90, 8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors
Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa
Yang, L., Liu, Y., Markussen, T., Høiby, Niels, Tolker-Nielsen, Tim & Molin, S., 1 Aug 2011, In: F E M S Immunology and Medical Microbiology. 62, 3, p. 339-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8656938
Most downloads
-
1317
downloads
Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
802
downloads
C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
328
downloads
Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Research output: Contribution to journal › Review › Research › peer-review
Published