Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

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    ORCID: 0000-0002-9751-474X

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    1. Published

      Inoculation method could impact the outcome of microbiological experiments

      Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

      Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    3. Published

      Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

      Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

      Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      CDy14: A novel biofilm probe targeting exopolysaccharide Psl

      Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells.

      Lange, M., Tolker-Nielsen, Tim, Molin, S. & Ahring, B. K., 2000, In: Applied and Environmental Microbiology. 66, 5, p. 1796-800 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa.

      Li, Y., Xia, H., Bai, F., Xu, H., Yang, L., Yao, H., Zhang, L., Zhang, X., Bai, Y., Saris, P. E. J., Tolker-Nielsen, Tim & Qiao, M., 2007, In: FEMS Microbiology Letters. 272, 2, p. 188-95 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP

      Liang, Z., Rybtke, Morten Levin, Kragh, K. N., Johnson, O., Schicketanz, Muriel Leandra, Zhang, Yong, Andersen, Jens Bo & Tolker-Nielsen, Tim, 2022, In: Microbiology Spectrum. 10, 4, 13 p., e00675-22.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The role of individual exopolysaccharides in antibiotic tolerance of Pseudomonas aeruginosa aggregates

      Liang, Z., Nilsson, M., Kragh, K. N., Hedal, I., Alcàcer-Almansa, J., Kiilerich, R. O., Andersen, Jens Bo & Tolker-Nielsen, Tim, 2023, In: Frontiers in Microbiology. 14, 1187708.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.

      Licht, T. R., Tolker-Nielsen, Tim, Holmstrøm, K., Krogfelt, K. & Molin, S., 1999, In: Environmental Microbiology. 1, 1, p. 23-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa

      Lichtenberg, Mads, Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2022, In: Cell Reports. 41, 3, p. 111515 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa

      Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Redox protein osar (pa0056) regulates dsbm and the oxidative stress response in pseudomonas aeruginosa

      Liu, Y., Ma, Y., Ma, Z., Han, X., Qi, H., Andersen, Jens Bo, Xu, H., Tolker-Nielsen, Tim & Qiao, M., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 3, e01771-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Bacteria can form interconnected microcolonies when a self-excreted product reduces their surface motility: evidence from individual-based model simulations

      Mabrouk, N., Deffuant, G., Tolker-Nielsen, Tim & Lobry, C., 2010, In: Theory in Biosciences. 129, 1, p. 1-13 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      A genetic switch controls Pseudomonas aeruginosa surface colonization

      Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia

      McCarthy, Y., Yang, L., Twomey, K. B., Sass, A., Tolker-Nielsen, Tim, Mahenthiralingam, E., Dow, J. M. & Ryan, R. P., 2010, In: Molecular Microbiology. 77, 5, p. 1220-1236 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Pseudomonas aeruginosa: A Model for Biofilm Formation

      McDougald, D., Klebensberger, J., Tolker-Nielsen, Tim, Webb, J. S., Conibear, T., Rice, S. A., Kirov, S. M., Matz, C. & Kjelleberg, S., 2008,   Pseudomonas. Model Organism, Pathogen, Cell Factory.. Rehm, B. H. A. (ed.). Wiley-VCH, p. 215-254 40 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    18. Published

      In silico analyses of metagenomes from human atherosclerotic plaque samples

      Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure.

      Molin, S. & Tolker-Nielsen, Tim, 2003, In: Current Opinion in Biotechnology. 14, 3, p. 255-61 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Molecular ecology of biofilms.

      Molin, S., Nielsen, A. T., Christensen, B. B., Andersen, J. B., Licht, T. R., Tolker-Nielsen, Tim, Sternberg, C., Hansen, M. C., Ramos, C. & Givskov, M., 2000, Biofilms.. Wiley, p. 89-120

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    21. Microbial interactions in mixed-species biofilms.

      Molin, S., Tolker-Nielsen, Tim & Hansen, S. K., 2004, Microbial biofilms.. Ghannoum, M. & O’Toole, G. A. (eds.). ASM International, p. 206-221

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    22. Published

      Immune Responses to Pseudomonas aeruginosa Biofilm Infections

      Moser, Claus Ernst, Jensen, Peter Østrup, Thomsen, K., Kolpen, M., Rybtke, Morten Levin, Lauland, A. S., Trøstrup, H. & Tolker-Nielsen, Tim, 2021, In: Frontiers in Immunology. 12, 625597.

      Research output: Contribution to journal › Review › Research › peer-review

    23. Published

      Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

      Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Role of commensal relationships on the spatial structure of a surface-attached microbial consortium.

      Nielsen, A. T., Tolker-Nielsen, Tim, Barken, K. B. & Molin, S., 2000, In: Environmental Microbiology. 2, 1, p. 59-68 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark

      Nielsen, K. L., Hammerum, A. M., Lambertsen, L. M., Lester, C. H., Arpi, M., Knudsen, J. D., Stegger, M., Tolker-Nielsen, Tim & Frimodt-Møller, N., 2010, In: Scandinavian Journal of Infectious Diseases. 42, 8, p. 586-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In: International Journal of Antimicrobial Agents. 48, 3, p. 298–304

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

      Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

      Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      A mariner transposon vector adapted for mutagenesis in oral streptococci

      Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Transposon Mutagenesis in Streptococcus Species

      Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, 2019, Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, p. 39-49 11 p. (Methods in Molecular Biology, Vol. 2016).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    32. Published

      A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation

      Okshevsky, M., Louw, M. G., Lamela, E. O., Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim & Meyer, R. L., 2018, In: MicrobiologyOpen. 7, 2, 17 p., e00552.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress

      Orlandi, V. T., Bolognese, F., Chiodaroli, L., Tolker-Nielsen, Tim & Barbieri, P., Dec 2015, In: Microbiology. 161, 12, p. 2298-309 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1

      Orlandi, V. T., Rybtke, Morten Levin, Caruso, E., Banfi, S., Tolker-Nielsen, Tim & Barbieri, P., Sep 2014, In: Biofouling. 30, 8, p. 883-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. The biofilm matrix - A sticky framework.

      Pamp, S., Gjermansen, M. & Tolker-Nielsen, Tim, 2007, The biofilm mode of life - Mechanisms and adaptations.. Kjelleberg, S. & Givskov, M. (eds.). HorizonBioscience, p. 37-69

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    36. Published

      Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

      Pamp, S. J., Gjermansen, M., Johansen, Helle Krogh & Tolker-Nielsen, Tim, 2008, In: Molecular Microbiology. 68, 1, p. 223-40 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.

      Pamp, S. J. & Tolker-Nielsen, Tim, 2007, In: Journal of Bacteriology. 189, 6, p. 2531-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy

      Pamp, S. J., Sternberg, C. & Tolker-Nielsen, Tim, 2009, In: Cytometry. Part A. 75, 2, p. 90-103 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Pattern formation in Pseudomonas aeruginosa biofilms.

      Parsek, M. R. & Tolker-Nielsen, Tim, 2008, In: Current Opinion in Microbiology. 11, p. 560-566 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Microbial motility involvement in biofilm structure formation--a 3D modelling study.

      Picioreanu, C., Kreft, J. U., Klausen, M., Haagensen, J. A. J., Tolker-Nielsen, Tim & Molin, S., 2007, In: Water Science and Technology. 55, 8-9, p. 337-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa

      Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis

      Qin, Z., Yang, L., Qu, D., Molin, S. & Tolker-Nielsen, Tim, 2009, In: Microbiology. 155, Pt 7, p. 2148-56 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.

      Qin, Z., Ou, Y., Yang, L., Zhu, Y., Tolker-Nielsen, Tim, Molin, S. & Qu, D., 2007, In: Microbiology. 153, Pt 7, p. 2083-92 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

      Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

      Research output: Contribution to journal › Review › Research › peer-review

    45. Microbial pathogenesis and biofilm development.

      Reisner, A., Høiby, N., Tolker-Nielsen, Tim & Molin, S., 2005, In: Contributions to Microbiology. 12, p. 114-31 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

      Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa

      Ring, H. C., Bay, Lene, Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.

      Ryan, R. P., Fouhy, Y., Garcia, B. F., Watt, S. A., Niehaus, K., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2008, In: Molecular Microbiology. 68, 1, p. 75-86 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      When the PilZ don't work: effectors for cyclic di-GMP action in bacteria

      Ryan, R. P., Tolker-Nielsen, Tim & Dow, J. M., May 2012, In: Current Trends in Microbiology. 20, 5, p. 235-242 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa

      Ryan, R. P., Lucey, J., O'Donovan, K., McCarthy, Y., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2009, In: Environmental Microbiology. 11, 5, p. 1126-36 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

      Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In: MicrobiologyOpen. 4, 6, p. 917-930 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

      Rybtke, Morten Levin, Hultqvist, Louise Dahl, Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645

      Research output: Contribution to journal › Review › Research › peer-review

    53. Published

      The Extracellular Polysaccharide Matrix of Pseudomonas aeruginosa Biofilms Is a Determinant of Polymorphonuclear Leukocyte Responses

      Rybtke, Morten Levin, Jensen, Peter Østrup, Nielsen, Claus Henrik & Tolker-Nielsen, Tim, 2021, In: Infection and Immunity. 89, 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Gauging and visualizing c-di-GMP levels in pseudomonas aeruginosa using fluorescence-based biosensors

      Rybtke, Morten Levin, Chua, S. L., Yam, J. K. H., Givskov, Michael, Yang, L. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 87-98 12 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    55. Published

      The implication of Pseudomonas aeruginosa biofilms in infections

      Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa.

      Rybtke, Morten Levin, Borlee, B. R., Murakami, K., Irie, Y., Hentzer, M., Nielsen, T. E., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, 2012, In: Applied and Environmental Microbiology. 78, 15, p. 5060-5069 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Biofilms can act as plasmid reserves in the absence of plasmid specific selection

      Røder, Henriette Lyng, Trivedi, Urvish, Russel, J., Kragh, K. N., Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: npj Biofilms and Microbiomes. 7, 6 p., 78.

      Research output: Contribution to journal › Letter › Research › peer-review

    58. Published

      High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111

      Schmid, N., Suppiger, A., Steiner, E., Pessi, G., Kaever, V., Fazli, M., Tolker-Nielsen, Tim, Jenal, U. & Eberl, L., 1 May 2017, In: Microbiology. 163, 5, p. 754-764 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions

      Schwarz, S., West, T. E., Boyer, F., Chiang, W., Carl, M. A., Hood, R. D., Rohmer, L., Tolker-Nielsen, Tim, Skerrett, S. J. & Mougous, J. D., 2010, In: PLoS Pathogens. 6, 8

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      The contribution of cell-cell signaling and motility to bacterial biofilm formation

      Shrout, J. D., Tolker-Nielsen, Tim, Givskov, Michael & Parsek, M. R., May 2011, In: M R S Bulletin. 36, 5, p. 367-373 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

      Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Identification of LasR ligands through a virtual screening approach

      Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit

      Soh, E., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Camara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, bioRxiv, 43 p.

      Research output: Working paper › Preprint › Research

    64. Published

      Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit

      Soh, E. Y. C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Cámara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, In: PLOS Pathogens. 17, 8, 25 p., e1009425.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

      Stacy, D. M., Le Quement, S. T., Hansen, C., Clausen, J. W., Tolker-Nielsen, Tim, Brummond, J. W., Givskov, Michael, Nielsen, T. E. & Blackwell, H. E., 2013, In: Organic & Biomolecular Chemistry. 11, 6, p. 938-54 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      The BDSF quorum sensing receptor RpfR regulates Bep exopolysaccharide synthesis in Burkholderia cenocepacia via interaction with the transcriptional regulator BerB

      Steiner, E., Shilling, R. E., Richter, A. M., Schmid, N., Fazli, M., Kaever, V., Jenal, U., Tolker-Nielsen, Tim & Eberl, L., 2022, In: npj Biofilms and Microbiomes. 8, 93.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Growing and analyzing biofilms in flow cells.

      Sternberg, C. & Tolker-Nielsen, Tim, 2006, In: Current Protocols in Microbiology. Chapter 1, p. Unit 1B.2

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

      Sun, J., Marais, J. P. J., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, Michael, Tolker-Nielsen, Tim, Seeram, N. P. & Rowley, D. C., Aug 2015, In: Journal of Functional Foods. 17, p. 235-242 8 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    69. Published

      Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

      Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82

      Tay, M., Roizman, D., Cohen, Y., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Genome Announcements. 2, 1, p. 1 1 p., e01161-13.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

      Teh, W. K., Dramsi, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species

      Thorsing, M., Bentin, Thomas, Givskov, Michael, Tolker-Nielsen, Tim & Goltermann, Lise, Oct 2015, In: Microbiology. 161, 10, p. 1999-2007 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Non-genetic population heterogeneity studied by in situ polymerase chain reaction.

      Tolker-Nielsen, Tim, Holmstrøm, K., Boe, L. & Molin, S., 1998, In: Molecular Microbiology. 27, 6, p. 1099-105 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Visualization of specific gene expression in individual Salmonella typhimurium cells by in situ PCR.

      Tolker-Nielsen, Tim, Holmstrøm, K. & Molin, S., 1997, In: Applied and Environmental Microbiology. 63, 11, p. 4196-203 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. The biofilm lifestyle of pseudomonads.

      Tolker-Nielsen, Tim & Molin, S., 2004, Pseudomonas. Ramos, J. (ed.). Kluwer Academic Publishers, p. 547-571

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    76. Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium.

      Tolker-Nielsen, Tim & Molin, S., 1996, In: FEMS Microbiology Letters. 142, 2-3, p. 155-60 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Effects of stress treatments on the detection of Salmonella typhimurium by in situ hybridization.

      Tolker-Nielsen, Tim, Larsen, M. H., Kyed, H. & Molin, S., 1997, In: International Journal of Food Microbiology. 35, 3, p. 251-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Pseudomonas aeruginosa biofilm infections: From molecular biofilm biology to new treatment possibilities

      Tolker-Nielsen, Tim, Dec 2014, 51 p. (APMIS Supplementum).

      Research output: Book/Report › Doctoral thesis › Research

    79. Published

      Biofilm development

      Tolker-Nielsen, Tim, 2015, Microbial biofilms. Ghannoum, M., Parsek, M., Whiteley, M. & P. M. (eds.). 2 ed. Washington DC: ASM Press, p. 51-66 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    80. Spatial Organization of Microbial Biofilm Communities.

      Tolker-Nielsen, Tim & Molin, S., 2000, In: Microbial Ecology. 40, 2, p. 75-84 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Biofilm development

      Tolker-Nielsen, Tim, 1 Jan 2015, Microbial Biofilms. Wiley-Interscience, p. 51-66 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    82. Biofilm development by pseudomonads.

      Tolker-Nielsen, Tim & Molin, S., 2004, Environmental Biotechnology. Verstraete, W. (ed.). CRC Press/Balkema, p. 27-32

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    83. Published

      Methods for studying biofilm formation: flow cells and confocal laser scanning microscopy

      Tolker-Nielsen, Tim & Sternberg, C., 2014, In: Methods in Molecular Biology. 1149, p. 615-29 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Biofilm Development

      Tolker-Nielsen, Tim, Mar 2015, In: Microbiology Spectrum. 3, 2, 12 p., MB-0001-2014.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy

      Tolker-Nielsen, Tim & Høiby, Niels, 2009, In: Future Microbiology. 4, p. 645-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Development and dynamics of Pseudomonas sp. biofilms.

      Tolker-Nielsen, Tim, Brinch, U. C., Ragas, P. C., Andersen, J. B., Jacobsen, C. S. & Molin, S., 2000, In: Journal of Bacteriology. 182, 22, p. 6482-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.

      Tolker-Nielsen, Tim & Boe, L., 1994, In: Journal of Bacteriology. 176, 14, p. 4306-10 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Growing and analyzing biofilms in flow chambers

      Tolker-Nielsen, Tim & Sternberg, C., 2011, In: Current Protocols in Microbiology. 21, p. 1B.2.1-1B.2.17

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells.

      Tolker-Nielsen, Tim, Christensen, A. B., Holmstrøm, K., Eberl, L., Rasmussen, T. B., Sternberg, C., Heydorn, A., Molin, S. & Givskov, M., 2000, In: Journal of Bacteriology. 182, 10, p. 2680-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier

      Tran, C. S., Rangel, S. M., Almblad, H., Kierbel, A., Givskov, Michael, Tolker-Nielsen, Tim, Hauser, A. R. & Engel, J. N., Nov 2014, In: P L o S Pathogens. 10, 11, p. 1-11 12 p., e1004479.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

      Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene, encoding a nitronate monooxygenase

      Vercammen, K., Wei, Q., Charlier, D., Dötsch, A., Haüssler, S., Schulz, S., Salvi, F., Gadda, G., Spain, J., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Dingemans, J., Ye, L. & Cornelis, P., Mar 2015, In: Journal of Bacteriology. 197, 6, p. 1026-39 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells

      Wang, V. B., Chua, S., Cao, B., Seviour, T., Nesatyy, V. J., Marsili, E., Kjelleberg, S., Givskov, Michael, Tolker-Nielsen, Tim, Song, H., Loo, J. S. C. & Yang, L., 2013, In: PLOS ONE. 8, 5, p. e63129 7 p., e63129.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Cell death in Pseudomonas aeruginosa biofilm development.

      Webb, J. S., Thompson, L. S., James, S., Charlton, T., Tolker-Nielsen, Tim, Koch, B., Givskov, M. & Kjelleberg, S., 2003, In: Journal of Bacteriology. 185, 15, p. 4585-92 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.

      Whitchurch, C. B., Beatson, S. A., Comolli, J. C., Jakobsen, T., Sargent, J. L., Bertrand, J. J., West, J., Klausen, M., Waite, L. L., Kang, P. J., Tolker-Nielsen, Tim, Mattick, J. S. & Engel, J. N., 2005, In: Molecular Microbiology. 55, 5, p. 1357-78 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Extracellular DNA required for bacterial biofilm formation.

      Whitchurch, C. B., Tolker-Nielsen, Tim, Ragas, P. C. & Mattick, J. S., 2002, In: Science. 295, 5559, p. 1487

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo

      Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, Morten Levin, Seliktar, D., Kofidis, T., Høiby, Niels, Tolker-Nielsen, Tim, Song, Z. & Givskov, Michael, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

      Yam, J. K. H., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Salido, M. M. S., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Boo, Z. Z., Wu, B., Kjelleberg, S., Tolker-Nielsen, T., Lakshminarayanan, R., Beuerman, R. W., Yang, L. & 1 others, Givskov, Michael, 2022, In: Infection and Immunity. 90, 8

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

      Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa

      Yang, L., Liu, Y., Markussen, T., Høiby, Niels, Tolker-Nielsen, Tim & Molin, S., 1 Aug 2011, In: F E M S Immunology and Medical Microbiology. 62, 3, p. 339-47 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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