Michael Givskov
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N, 22 Bygning 22, Building: 22-2-22
Member of:
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Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis
Moser, C., Gennip, M. V., Bjarnsholt, Thomas, Jensen, Peter Østrup, Lee, B., Hougen, H. P., Calum, H., Ciofu, Oana, Givskov, Michael, Molin, S. & Høiby, Niels, 1 Feb 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 2, p. 95-107 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis
Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, 2005, In: Infection and Immunity. 73, 4, p. 2504-14 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Observations on the formation of deletions on monomeric and dimeric plasmids in Escherichia coli
Ravn, P., Givskov, Michael, Eegholm, K. M., Madsen, S. M. & Boe, L., 1994, In: Molecular Microbiology. 14, 2, p. 263-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms
Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342Research output: Contribution to journal › Journal article › Research › peer-review
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PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples
Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Periodontitis associates with species-specific gene expression of the oral microbiota
Midjord-Belstrøm, Daniel, Constancias, F., Drautz-Moses, D. I., Schuster, S. C., Veleba, M., Mahé, F. & Givskov, Michael, 2021, In: npj Biofilms and Microbiomes. 7, 76.Research output: Contribution to journal › Journal article › Research › peer-review
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Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones
Le Quement, S. T., Flagstad, T., Mikkelsen, R. J. T., Hansen, M. R., Givskov, Michael & Nielsen, T. E., 2012, In: Organic Letters. 14, 2, p. 640-643 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
Hentzer, M. & Givskov, Michael, 2003, In: Journal of Clinical Investigation. 112, 9, p. 1300-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes
Eilers, K., Kuok Hoong Yam, J., Morton, R., Mei Hui Yong, A., Brizuela, J., Hadjicharalambous, C., Liu, X., Givskov, Michael, Rice, S. A. & Filloux, A., 2022, In: Frontiers in Microbiology. 13, 949597.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system
Danhorn, T., Hentzer, M., Givskov, Michael, Parsek, M. R. & Fuqua, C., 2004, In: Journal of Bacteriology. 186, 14, p. 4492-501 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa
Yang, L., Hengzhuang, W., Wu, H., Damkiaer, S., Jochumsen, N., Song, Z., Givskov, Michael, Høiby, Niels & Molin, S., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 366-376 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients
Wen, H., Wang, K., Liu, Y., Tay, M., Lauro, F. M., Huang, H., Wu, H., Liang, H., Ding, Y., Givskov, Michael, Chen, Y. & Yang, L., Sep 2014, In: Journal of clinical microbiology. 52, 9, p. 3200-3208 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Presence of acylated homoserine lactones (AHLs) and AHL-producing bacteria in meat and potential role of AHL in spoilage of meat
Bruhn, J. B., Christensen, A. B., Flodgaard, L. R., Nielsen, K. F., Larsen, T. O., Givskov, Michael & Gram, L., 2004, In: Applied and Environmental Microbiology. 70, 7, p. 4293-302 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Process for the manufacture of ajoene derivatives
Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
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Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis
Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: F E M S Microbiology Letters. 184, 2, p. 273-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Production of N-acyl-L-homoserine lactones by Pseudomonas aeruginosa isolates from chronic lung infections associated with cystic fibrosis
Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: FEMS Microbiology Letters. 184, p. 273-278Research output: Contribution to journal › Journal article › Research › peer-review
Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods
Gram, L., Christensen, A. B., Ravn, L., Molin, S. & Givskov, Michael, 1999, In: Applied and Environmental Microbiology. 65, 8, p. 3458-63 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production
Kastbjerg, V. G., Nielsen, K. F., Dalsgaard, I., Rasch, M., Bruhn, J. B., Givskov, Michael & Gram, L., 2007, In: Journal of Applied Microbiology. 102, 2, p. 363-74 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response
Bobadilla Fazzini, R. A., Skindersoe, M. E., Bielecki, P., Puchalka, J., Givskov, Michael & Martins sos Santos, V. A. P., 2013, In: Environmental Microbiology Reports. 15, 1, p. 111-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion
Alhede, M., Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., 2014, In: Advances in Applied Microbiology. 86, p. 1-40 40 p.Research output: Contribution to journal › Journal article › Research
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Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.
Bagge, N., Schuster, M., Hentzer, M., Ciofu, Oana, Givskov, Michael, Greenberg, E. P. & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1175-87 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection
Wu, H., Song, Z., Givskov, Michael, Doring, G., Worlitzsch, D., Mathee, K., Rygaard, J. & Høiby, Niels, 2001, In: Microbiology. 147, Pt 5, p. 1105-1113 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa quorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation
Skindersoe, M. E., Zeuthen, L. H., Brix, Susanne, Fink, L. N., Lazenby, J., Whittall, C., Williams, P., Diggle, S. P., Frøkiær, Hanne, Cooley, M. & Givskov, Michael, 2009, In: FEMS Immunology and Medical Microbiology. 55, 3, p. 335-45 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection
Zhu, H., Bandara, R., Conibear, T. C. R., Thuruthyil, S. J., Rice, S. A., Kjelleberg, S., Givskov, Michael & Willcox, M. D. P., 2004, In: Investigative Ophthalmology & Visual Science. 45, 6, p. 1897-903 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation
Yang, L., Nilsson, Carl Martin Peter, Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Molecular Microbiology. 74, 6, p. 1380-92 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro
Jakobsen, Tim Holm, Alhede, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Qualitative and quantitative determination of quorum sensing inhibition in vitro
Jakobsen, Tim Holm, van Gennip, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 1 Jan 2011, In: Methods in Molecular Biology. 692, 3, p. 253-263 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantification of biofilm structures by the novel computer program COMSTAT
Heydorn, A., Nielsen, A. T., Hentzer, M., Sternberg, C., Givskov, Michael, Ersbøll, B. K. & Molin, S., 2000, In: Microbiology. 146 ( Pt 10), p. 2395-407 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds
Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, A., Andersen, C. B., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Wound Repair and Regeneration. 19, 3, p. 387-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative effects of medium hardness and nutrient availability on the swarming motility of Serratia liquefaciens
Bees, M. A., Andresén, P., Mosekilde, E. & Givskov, Michael, 2002, In: Bulletin of Mathematical Biology. 64, 3, p. 565-87 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing : a novel target for the treatment of biofilm infections
Hentzer, M., Eberl, L., Nielsen, J. & Givskov, Michael, 2003, In: BioDrugs. 17, 4, p. 241-50 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing antagonism from marine organisms
Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, Thomas, de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing antagonism from marine organisms
Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, T., de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the autoinducer synthase AsaI on bacterial virulence
Schwenteit, J., Gram, L., Nielsen, K. F., Fridjonsson, O. H., Bornscheuer, U. T., Givskov, Michael & Gudmundsdottir, B. K., 2011, In: Veterinary Microbiology. 147, 3-4, p. 389-97Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing in Gram-negative bacteria
Wu, H., Song, Z., Høiby, Niels & Givskov, Michael, May 2004, In: Progress in Natural Science. 14, 5, p. 377-387 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing in Serratia
Van Houdt, R., Givskov, Michael & Michiels, C. W., 2007, In: FEMS Microbiology Reviews. 31, 4, p. 407-24 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria
Persson, T., Givskov, Michael & Nielsen, J., 2005, In: Current Medicinal Chemistry. 12, 26, p. 3103-15 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing inhibitors disable bacterial biofilms.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Quorum sensing inhibitors: a bargain of effects
Rasmussen, T. B. & Givskov, Michael, 2006, In: Microbiology. 152, Pt 4, p. 895-904 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
Bjarnsholt, Thomas & Givskov, Michael, 2008, In: Current Infectious Disease Reports. 10, 1, p. 22-28 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing regulation in Aeromonas hydrophila
Garde, C., Bjarnsholt, Thomas, Givskov, Michael, Jakobsen, Tim Holm, Hentzer, M., Claussen, A., Sneppen, K., Ferkinghoff-Borg, J. & Sams, T., 2010, In: Journal of Molecular Biology. 396, 4, p. 849-57 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor
Rasch, M., Kastbjerg, V. G., Bruhn, J. B., Dalsgaard, I., Givskov, Michael & Gram, L., 2007, In: Diseases of Aquatic Organisms. 78, 2, p. 105-13 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing systems contribute to the severity of the lung infection of pseudomonas aeruginosa in rats
Wu, H., Song, Z. J., Givskov, Michael, Mathee, K., Rygaard, J. & Høiby, Niels, 1999, In: Pediatric Pulmonology. Suppl 19, p. 269-269Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1
Labbate, M., Queck, S. Y., Koh, K. S., Rice, S. A., Givskov, Michael & Kjelleberg, S., 2004, In: Journal of Bacteriology. 186, 3, p. 692-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens
Bjarnsholt, T. & Givskov, Michael, 2007, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 362, 1483, p. 1213-22 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria
Holden, M. T., Ram Chhabra, S., de Nys, R., Stead, P., Bainton, N. J., Hill, P. J., Manefield, M., Kumar, N., Labatte, M., England, D., Rice, S., Givskov, Michael, Salmond, G. P., Stewart, G. S., Bycroft, B. W., Kjelleberg, S. & Williams, P. F., 1999, In: Molecular Microbiology. 33, 6, p. 1254-66 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing inhibitors as anti-pathogenic drugs
Rasmussen, T. B. & Givskov, Michael, 2006, In: International Journal of Medical Microbiology. 296, 2-3, p. 149-61 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent
Labbate, M., Zhu, H., Thung, L., Bandara, R., Larsen, M. R., Willcox, M. D. P., Givskov, Michael, Rice, S. A. & Kjelleberg, S., 2007, In: Journal of Bacteriology. 189, 7, p. 2702-11 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing-directed protein expression in Serratia proteamaculans B5a
Christensen, A. B., Riedel, K., Eberl, L., Flodgaard, L. R., Molin, S., Gram, L. & Givskov, Michael, 2003, In: Microbiology. 149, Pt 2, p. 471-83 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots
Andersen, A. S., Joergensen, B., Bjarnsholt, Thomas, Johansen, H., Karlsmark, T., Givskov, Michael, Krogfelt, K. A., Andersen, A. S., Jørgensen, B., Bjarnsholt, T., Johansen, H., Karlsmark, Tonny, Givskov, M. & Krogfelt, K. A., 1 Feb 2010, In: Microbiology. 156, Pt 2, p. 400-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa
Jensen, Peter Østrup, Bjarnsholt, Thomas, Phipps, R., Rasmussen, T. B., Calum, H., Christoffersen, L., Moser, C., Williams, P., Pressler, T., Givskov, Michael & Høiby, Niels, 2007, In: Microbiology. 153, Pt 5, p. 1329-38 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic
Persson, T., Hansen, T. H., Rasmussen, T. B., Skindersø, M. E., Givskov, Michael & Nielsen, J., 2004, In: Organic & Biomolecular Chemistry. 3, 2, p. 253-62 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels
Chua, S. L., Ding, Y., Liu, Y., Cai, Z., Zhou, J., Swarup, S., Drautz-Moses, D. I., Schuster, S. C., Kjelleberg, S., Givskov, Michael & Yang, L., Nov 2016, In: Open Biology. 6, 13 p., 160162.Research output: Contribution to journal › Journal article › Research › peer-review
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Reactivity and Synthetic Applications of Multicomponent Petasis Reactions
Wu, P., Givskov, Michael & Nielsen, Thomas Eiland, 2019, In: Chemical Reviews. 119, 20, p. 11245-11290 46 p.Research output: Contribution to journal › Review › Research › peer-review
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Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa
Chua, S. L., Liu, Y., Li, Y., Ting, H. J., Kohli, G. S., Cai, Z., Suwanchaikasem, P., Goh, K. K. K., Ng, S. P., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Oct 2017, In: Frontiers in Cellular and Infection Microbiology. 7, 8 p., 451.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB
Fazli, M., Rybtke, Morten Levin, Steiner, E., Weidel, E., Berthelsen, J., Groizeleau, J. D. D., Bin, W., Zhi, B. Z., Yaming, Z., Kaever, V., Givskov, Michael, Hartmann, R. W., Eberl, L. & Tolker-Nielsen, Tim, 2017, In: MicrobiologyOpen. 6, 4, 13 p., e00480.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of biofilm formation in Pseudomonas and Burkholderia species
Fazli, M., Almblad, H., Rybtke, Morten Levin, Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2014, In: Environmental Microbiology. 16, 7, p. 1961-1981 21 p.Research output: Contribution to journal › Review › Research › peer-review
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Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents
Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Hoong Yam, J. K., Aung, T. T., Beuerman, R. W., Santillan Salido, M. M., Schuster, S. C., Tan, C. H., Givskov, Michael, Yang, L. & Nielsen, Thomas Eiland, 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 3059-3069 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Responses to nutrient starvation in Pseudomonas putida KT2442: analysis of general cross-protection, cell shape, and macromolecular content
Givskov, Michael, Eberl, L., Møller, S., Poulsen, L. K. & Molin, S., 1994, In: Journal of Bacteriology. 176, 1, p. 7-14 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis
Willcox, M. D. P., Zhu, H., Conibear, T. C. R., Hume, E. B. H., Givskov, Michael, Kjelleberg, S. & Rice, S. A., 2008, In: Microbiology. 154, Pt 8, p. 2184-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms
Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RpoN Regulates Virulence Factors of Pseudomonas aeruginosa via Modulating the PqsR Quorum Sensing Regulator
Cai, Z., Liu, Y., Chen, Y., Yam, J. K. H., Chew, S. C., Chua, S. L., Wang, K., Givskov, Michael & Yang, L., Dec 2015, In: International Journal of Molecular Sciences. 16, 12, p. 28311-28319 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms
Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector
Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Köte, M., Nielsen, J., Eberl, L. & Givskov, Michael, 2005, In: Journal of Bacteriology. 187, 5, p. 1799-814 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Secretion of Serratia liquefaciens phospholipase from Escherichia coli
Givskov, Michael & Molin, S., 1993, In: Molecular Microbiology. 8, 2, p. 229-42 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms
Chua, S. L., Yam, J. K. H., Hao, P., Adav, S. S., Salido, M. M., Liu, Y., Givskov, Michael, Sze, S. K., Tolker-Nielsen, Tim & Yang, L., 2016, In: Nature Communications. 7, 11 p., 10750.Research output: Contribution to journal › Journal article › Research › peer-review
Serratia liquefaciens swarm cells exhibit enhanced resistance to predation by Tetrahymena sp
Ammendola, A., Geisenberger, O., Andersen, J. B., Givskov, Michael, Schleifer, K. H. & Eberl, L., 1998, In: F E M S Microbiology Letters. 164, 1, p. 69-75 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Silver against Pseudomonas aeruginosa biofilms
Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Site-specific deletions of chromosomally located DNA segments with the multimer resolution system of broad-host-range plasmid RP4
Kristensen, C. S., Eberl, L., Sanchez-Romero, J. M., Givskov, Michael, Molin, S. & De Lorenzo, V., 1995, In: Journal of Bacteriology. 177, 1, p. 52-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation
Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.Research output: Contribution to journal › Review › Research › peer-review
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Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators
Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors
Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence
Komnatnyy, V. V., Givskov, Michael & Nielsen, T. E., Dec 2012, In: Chemistry. A European Journal. 18, 52, p. 16793-16800 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatially extensive microbial biogeography of the Indian Ocean provides insights into the unique community structure of a pristine coral atoll
Jeffries, T. C., Ostrowski, M., Williams, R. B., Xie, C., Jensen, R. M., Grzymski, J. J., Senstius, S. J., Givskov, Michael, Hoeke, R., Philip, G. K., Neches, R. Y., Drautz-Moses, D. I., Chenard, C., Paulsen, I. T. & Lauro, F. M., 20 Oct 2015, In: Scientific Reports. 5, 13 p., 15383 .Research output: Contribution to journal › Journal article › Research › peer-review
Suicidal genetic elements and their use in biological containment of bacteria
Molin, S., Boe, L., Jensen, L. B., Kristensen, C. S., Givskov, Michael, Ramos, J. L. & Bej, A. K., 1993, In: Annual Review of Microbiology. 47, p. 139-66 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface motility in Pseudomonas sp. DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum
Andersen, Jens Bo, Koch, B., Nielsen, T. H., Sørensen, D., Hansen, M., Nybroe, O., Christophersen, C., Sørensen, J., Molin, S. & Givskov, Michael, 2003, In: Microbiology. 149, Pt 1, p. 37-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Surface motility of serratia liquefaciens MG1
Eberl, L., Molin, S. & Givskov, Michael, 1999, In: Journal of Bacteriology. 181, 6, p. 1703-12 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Survival of, and induced stress resistance in, carbon-starved Pseudomonas fluorescens cells residing in soil
van Overbeek, L. S., Eberl, L., Givskov, Michael, Molin, S. & van Elsas, J. D., 1995, In: Applied and Environmental Microbiology. 61, 12, p. 4202-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing
Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Wu, B., Su, H. & Yang, L., 2017, bioRxiv, 27 p.Research output: Working paper › Preprint › Research
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Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators
Stacy, D. M., Le Quement, S. T., Hansen, C., Clausen, J. W., Tolker-Nielsen, Tim, Brummond, J. W., Givskov, Michael, Nielsen, T. E. & Blackwell, H. E., 2013, In: Organic & Biomolecular Chemistry. 11, 6, p. 938-54 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics
Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, Thomas Eiland, 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of Substituted γ- and δ-Lactams through Mannich-Type Reactions of Solid-Supported N-Acyliminium Ions
Komnatnyy, V. V., Taveras, K. M., Nandurkar, N. S., Le Quement, S. T., Givskov, Michael & Nielsen, T. E., Jun 2015, In: European Journal of Organic Chemistry. 2015, 16, p. 3524-3530 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity
Hjelmgaard, T., Persson, T., Rasmussen, T. B., Givskov, Michael & Nielsen, J., 2003, In: Bioorganic & Medicinal Chemistry. 11, 15, p. 3261-71 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers
Olsen, J. A., Severinsen, R. E., Rasmussen, T. B., Hentzer, M., Givskov, Michael & Nielsen, J., 2002, In: Bioorganic & Medicinal Chemistry Letters. 12, 3, p. 325-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers
Olsen, J. A., Severinsen, R., Rasmussen, T. B., Hentzer, M., Givskov, Michael, Nielsen, J. & Nielsen, J., 11 Feb 2002, In: Bioorganic and Medicinal Chemistry Letters. 12, 3, p. 325-328 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice
Wu, H., Song, Z., Hentzer, M., Andersen, Jens Bo, Molin, S., Givskov, Michael & Høiby, Niels, 2004, In: Journal of Antimicrobial Chemotherapy. 53, 6, p. 1054-61 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting quorum sensing for treatment of chronic bacterial biofilm infections
Hentzer, M., Givskov, Michael & Parsek, M. R., 2002, In: Laboratory Medicine. 33, 4, p. 295-306 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors
Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Acquisition of Resistance to Carbapenem and Macrolide-mediated Quorum Sensing Inhibition by Pseudomonas aeruginosa via a Novel Integrative and Conjugative Element ICETn43716385
Ding, Y., Teo, J., Drautz-Moses, D. I., Schuster, S. C., Givskov, Michael & Yang, L., 2017, bioRxiv, 95 p.Research output: Working paper › Preprint › Research
- Published
The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells
Gall Mas, Laura, Fabbri, A., Namini, Martin Rich Javadi, Givskov, Michael, Fiorentini, C. & Krejsgaard, T., 2018, In: International Journal of Molecular Sciences . 19, 5, 11 p., 1408.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia
Fazli, M., O'Connell, A., Nilsson, M., Niehaus, K., Dow, J. M., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, 2011, In: Molecular Microbiology. 82, 2, p. 327-41Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data
Lauro, F. M., Senstius, S. J., Cullen, J., Neches, R., Jensen, R. M., Brown, M. V., Darling, A. E., Givskov, Michael, McDougald, D., Hoeke, R., Ostrowski, M., Philip, G. K., Paulsen, I. T. & Grzymski, J. J., 2014, In: PLOS Biology. 12, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP
Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface
Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In: MicrobiologyOpen. 4, 6, p. 917-930 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5838523
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
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