Thomas Bjarnsholt
Professor
Bacteriology
Nørre Allé 14
2200 København N
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Introduction to Biofilm Infections
Bjarnsholt, Thomas, 2010, Biofilm Infections. New YorkResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Into the well—A close look at the complex structures of a microtiter biofilm and the crystal violet assay
Kragh, K. N., Alhede, M., Kvich, Lasse Andersson & Bjarnsholt, Thomas, 2019, In: Biofilm. 1, 9 p., 100006.Research output: Contribution to journal › Journal article › Research › peer-review
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Interspecific bacterial interactions are reflected in multispecies biofilm spatial organization
Liu, W., Røder, Henriette Lyng, Madsen, Jonas Stenløkke, Bjarnsholt, Thomas, Sørensen, Søren Johannes & Burmølle, Mette, 2016, In: Frontiers in Microbiology. 7, 8 p., 1366.Research output: Contribution to journal › Review › Research › peer-review
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Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin
Woetmann, Anders , Alhede, M., Dabelsteen, Sally, Bjarnsholt, Thomas, Rybtke, Morten Levin, Nastasi, C., Krejsgaard, T., Andersen, Mads Hald, Bonefeld, Charlotte Menne, Geisler, Carsten, Givskov, Michael & Ødum, Niels, 2018, In: OncoTarget. 9, 28, p. 19481-19489 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interfering with bacterial gossip.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interactions in multispecies biofilms: do they actually matter?
Burmølle, Mette, Ren, D., Bjarnsholt, Thomas & Sørensen, Søren Johannes, 2014, In: Trends in Microbiology. 22, 2, p. 84-91 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo
van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculum Concentration Influences Pseudomonas aeruginosa Phenotype and Biofilm Architecture
Lichtenberg, Mads, Kvich, Lasse Andersson, Larsen, S. L. B., Jakobsen, Tim Holm & Bjarnsholt, Thomas, 2022, In: Microbiology Spectrum. 10, 6Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculation method could impact the outcome of microbiological experiments
Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Injection site microflora in persons with diabetes: why needle reuse is not associated with increased infections?
Wareham-Mathiassen, S., Bay, Lene, Glenting, V. P., Fatima, N., Bengtsson, H. & Bjarnsholt, Thomas, 2022, In: APMIS. 130, 7, p. 404-416 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump
Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2Research output: Contribution to journal › Journal article › Research › peer-review
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Inflammation in Achromobacter xylosoxidans infected cystic fibrosis patients
Hansen, C. R., Pressler, T., Nielsen, K. G., Jensen, Peter Østrup, Bjarnsholt, Thomas & Høiby, Niels, 1 Jan 2010, In: Journal of Cystic Fibrosis. 9, 1, p. 51-58 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased severity of chronic Pseuomonas aeruginosa biofilm infection in the smaller airways of BALB/C mice
Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.Research output: Contribution to conference › Poster › Research › peer-review
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Increased severity of chronic Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice
Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions
Kolpen, Mette, Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In: Pathogens and Disease. 74, 1, 7 p., ftv086.Research output: Contribution to journal › Journal article › Research › peer-review
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Incidence of Propionibacterium acnes in initially culture-negative thioglycollate broths: a prospective cohort study at a Danish University Hospital
Kvich, Lasse Andersson, Jensen, Peter Østrup, Justesen, U. S. & Bjarnsholt, Thomas, Nov 2016, In: Clinical Microbiology and Infection. 22, 11, p. 941-945Research output: Contribution to journal › Journal article › Research › peer-review
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Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes
Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inactivation of Pseudomonas aeruginosa biofilm after ultraviolet light-emitting diode treatment: a comparative study between ultraviolet C and ultraviolet B
Argyraki, A., Markvart, Merete, Bjørndal, Lars, Bjarnsholt, Thomas & Petersen, P. M., 2017, In: Journal of Biomedical Optics. 22, 6, 7 p., 65004.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo gentamicin susceptibility test for prevention of bacterial biofilms in bone tissue and on implants
Jensen, Louise Kruse, Bjarnsholt, Thomas, Kragh, K. N., Aalbæk, Bent, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie, Pankoke, K., Petersen, A. & Jensen, Henrik Elvang, 2019, In: Antimicrobial Agents and Chemotherapy. 63, 2, 10 p., e01889-18.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect
Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In silico analyses of metagenomes from human atherosclerotic plaque samples
Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.Research output: Contribution to journal › Journal article › Research › peer-review
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In memoriam-Mark E. Shirtliff (1969-2018)
Coenye, T., Bjarnsholt, Thomas, Stoodley, P. & Rumbaugh, K., 2018, In: Pathogens and Disease. 76, 7, fty068.Research output: Contribution to journal › Editorial › Research
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In Situ Monitoring of the Antibacterial Activity of a Copper-Silver Alloy Using Confocal Laser Scanning Microscopy and pH Microsensors
Ciacotich, N., Kragh, K. N., Lichtenberg, Mads, Tesdorpf, J. E., Bjarnsholt, Thomas & Gram, L., 2019, In: Global Challenges. 3, 11, 9 p., 1900044.Research output: Contribution to journal › Journal article › Research › peer-review
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Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air
Jensen, Peter Østrup, Møller, S. A., Lerche, C. J., Moser, Claus Ernst, Bjarnsholt, Thomas, Ciofu, Oana, Faurholt-Jepsen, Daniel, Høiby, Niels & Kolpen, Mette, 2019, In: Biofilm. 1, 4 p., 100008.Research output: Contribution to journal › Journal article › Research › peer-review
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Implants induce a new niche for microbiomes
Jakobsen, Tim Holm, Eickhardt, S. R., Gheorghe, Alexandra Gabriella, Stenqvist, C., Sønderholm, M., Stavnsberg, C., Jensen, Peter Østrup, Odgaard, Anders, Whiteley, M., Moser, Claus Ernst, Hvolris, J., Hougen, H. P. & Bjarnsholt, Thomas, 1 Aug 2018, In: APMIS - Journal of Pathology, Microbiology and Immunology. 126, 8, p. 685-692 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model
Hultqvist, Louise Dahl, Moser, C., Jensen, Peter Østrup, Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Imaging N-acyl homoserine lactone quorum sensing in vivo
Hultqvist, Louise Dahl, Alhede, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Imaging N-acyl homoserine lactone quorum sensing in vivo
Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of pathogenic microorganisms directly from positive blood vials by matrix-assisted laser desorption/ionization time of flight mass spectrometry
Nonnemann, B., Tvede, M. & Bjarnsholt, Thomas, 18 Jan 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 9, p. 871-877 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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IWII Wound Infection in Clinical Practice consensus document: 2022 update
Swanson, T., Ousey, K., Haesler, E., Bjarnsholt, Thomas, Carville, K., Idensohn, P., Kalan, L., Keast, D. H., Larsen, D., Percival, S., Schultz, G., Sussman, G., Waters, N. & Weir, D., 2022, In: Journal of Wound Care. 31, S12, p. S10-S21Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients
Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, K. N., Bjarnsholt, Thomas & Kolpen, Mette, 2019, In: Journal of Cystic Fibrosis. 18, 5, p. 657–664Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin
Kolpen, Mette, Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Histologic changes and gene expression patterns in biopsy specimens from bacteria-inoculated and noninoculated excisional body and limb wounds in horses healing by second intention
Jørgensen, Elin , Hjerpe, F. B., Hougen, H. P., Bjarnsholt, Thomas, Berg, Lise Charlotte & Jacobsen, Stine, 2020, In: American Journal of Veterinary Research. 81, 3, p. 276-284 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heading for centennial anniversary and beyond
Norrild, B., Ralfkiaer, E., Bjarnsholt, Thomas & Jensen, Peter Østrup, Dec 2017, In: APMIS. 125, 12, p. 1133-1133Research output: Contribution to journal › Editorial › Research
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Har ny teknologi overflødiggjort Grams farvemetode? Dansk Selskab for Klinisk Mikrobiologi
Johansen, Helle Krogh, Bjarnsholt, Thomas, Høiby, Niels & Dansk Selskab for Klinisk Mikrobiologi, D. S. F. K. M., 17 Mar 2008, In: Ugeskrift for læger. 170, 12, p. 1041Research output: Contribution to journal › Journal article › Research › peer-review
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Haematoxylin and eosin staining identifies medium to large bacterial aggregates with a reliable specificity: A comparative analysis of follicular bacterial aggregates in axillary biopsies using peptide nucleic acid-fluorescence in situ hybridization and haematoxylin and eosin staining
Ring, H. C., Riis, P. T., Bay, Lene, Kallenbach, K., Bjarnsholt, Thomas & Jemec, Gregor, Oct 2017, In: Experimental Dermatology. 26, 10, p. 943-945Research output: Contribution to journal › Letter › Research › peer-review
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HUMAN SKIN MICROORGANISMS ARE DISTRIBUTED IN BIOFILM AGGREGATES AT WOUND EDGES
Bay, Lene, Agren, M. S., Poulsen, Steen Seier, Ghathian, K. S. A., Calum, H. & Bjarnsholt, Thomas, 2015, In: Wound Repair and Regeneration. 23, 4, p. A3-A3 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants
Ciofu, Oana, Mandsberg, L. F., Bjarnsholt, Thomas, Wassermann, T. & Høiby, Niels, 2010, In: Microbiology. 156, p. 1108-1119 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H., Rygaard, J., Moser, C., Eberl, L., Høiby, N. & Givskov, M., 2005, In: Microbiology. 151, Pt 12, p. 3873-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H. P., Rygaard, J., Moser, C., Eberl, L., Høiby, Niels & Givskov, M. C., 1 Dec 2005, In: Microbiology. 151, Pt 12, p. 3873-80 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing.
Høiby, Niels, Johansen, Helle Krogh, Ciofu, Oana, Jensen, Peter Østrup, Bjarnsholt, Thomas & Givskov, Michael, 2007, In: Ugeskrift for læger. 169, 48, p. 4163-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth
Høiby, Niels, Henneberg, K. Å., Wang, H., Stavnsbjerg, Camilla, Bjarnsholt, Thomas, Ciofu, Oana, Johansen, U. R. & Sams, T., 2019, In: International Journal of Antimicrobial Agents. 53, 5, p. 564-573Research output: Contribution to journal › Journal article › Research › peer-review
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Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorescence in situ hybridization for the tissue detection of bacterial pathogens associated with porcine infections.
Jensen, Henrik Elvang, Jensen, Louise Kruse, Barington, Kristiane, Pors, S. E., Bjarnsholt, Thomas & Boye, M., 2015, In: Methods in Molecular Biology. 1247, p. 219-134 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme high local intra-operative gentamicin concentrations are needed to prevent biofilm formation in-vivo
Jensen, Louise Kruse, Bjarnsholt, Thomas, Henriksen, Nicole Lind, Kragh, K. N. & Jensen, Henrik Elvang, 6 Sep 2018.Research output: Contribution to conference › Conference abstract for conference › Communication
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Extensive debridement is fundamental for the success of an absorbable gentamicin loaded bio-composite
Jensen, Louise Kruse, Blirup-Plum, Sophie Amalie, Aalbæk, Bent, Bjarnsholt, Thomas, Kragh, K. N., Gottlieb, H., Bue, M. & Jensen, Henrik Elvang, 12 Sep 2019.Research output: Contribution to conference › Conference abstract for conference › Communication
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Exhaled breath analysis using electronic nose in cystic fibrosis and primary ciliary dyskinesia patients with chronic pulmonary infections
Joensen, O., Paff, T., Haarman, E. G., Skovgaard, I. M., Jensen, Peter Østrup, Bjarnsholt, Thomas & Nielsen, Kim G., 2014, In: PLOS ONE. 9, 12, p. 1-15 15 p., e115584.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9755066
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
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