Michael Givskov

Michael Givskov

Professor

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    ORCID: 0000-0001-5004-8609

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    1. Published

      Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence

      Ferreira, A. A., Silva, I. I., Oliveira, V. V., Becker, J. J., Givskov, Michael, Ryan, R. R., Fernandes, F. & Moreira, L. M., May 2013, In: Applied and Environmental Microbiology. 79, 9, p. 3009-3020 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

      Fexby, S., Bjarnsholt, Thomas, Jensen, Peter Østrup, Roos, V., Høiby, Niels, Givskov, Michael & Klemm, P., 2006, In: Infection and Immunity. 75, 1, p. 30-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Combining the Petasis 3-Component Reaction with Multiple Modes of Cyclization: A Build/Couple/Pair Strategy for the Synthesis of Densely Functionalized Small Molecules

      Flagstad, T., Hansen, M. R., Le Quementt, S. T., Givskov, Michael & Nielsen, T. E., Jan 2015, In: A C S Combinatorial Science. 17, 1, p. 19-23 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

      Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics

      Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, Thomas Eiland, 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Nonbioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-Hydroxyoctanoyl)homoserine lactone

      Flodgaard, L. R., Dalgaard, P., Andersen, Jens Bo, Nielsen, K. F., Givskov, Michael & Gram, L., 2005, In: Applied and Environmental Microbiology. 71, 4, p. 2113-20 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing

      Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Wu, B., Su, H. & Yang, L., 2017, bioRxiv, 27 p.

      Research output: Working paper › Preprint › Research

    8. Published

      Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

      Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

      Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

      Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Liu, X., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells

      Gall Mas, Laura, Fabbri, A., Namini, Martin Rich Javadi, Givskov, Michael, Fiorentini, C. & Krejsgaard, T., 2018, In: International Journal of Molecular Sciences . 19, 5, 11 p., 1408.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Quorum sensing regulation in Aeromonas hydrophila

      Garde, C., Bjarnsholt, Thomas, Givskov, Michael, Jakobsen, Tim Holm, Hentzer, M., Claussen, A., Sneppen, K., Ferkinghoff-Borg, J. & Sams, T., 2010, In: Journal of Molecular Biology. 396, 4, p. 849-57 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

      Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: F E M S Microbiology Letters. 184, 2, p. 273-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Production of N-acyl-L-homoserine lactones by Pseudomonas aeruginosa isolates from chronic lung infections associated with cystic fibrosis

      Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: FEMS Microbiology Letters. 184, p. 273-278

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Copy mutants of plasmid R1: effects of base pair substitutions in the copA gene on the replication control system

      Givskov, Michael & Molin, S., 1984, In: Molecular and General Genetics MGG. 194, 1-2, p. 286-92 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Identification and characterization of mutations responsible for a runaway replication phenotype of plasmid R1

      Givskov, Michael, Stougaard, P., Light, J. & Molin, S., 1987, In: Gene. 57, 2-3, p. 203-11 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Cloning and expression in Escherichia coli of the gene for extracellular phospholipase A1 from Serratia liquefaciens

      Givskov, Michael, Olsen, L. & Molin, S., 1988, In: Journal of Bacteriology. 170, 12, p. 5855-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed and regulated by anaerobiosis

      Givskov, Michael & Molin, S., 1992, In: Molecular Microbiology. 6, 10, p. 1363-74 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

      Givskov, Michael, de Nys, R., Manefield, M., Gram, L., Maximilien, R., Eberl, L., Molin, S., Steinberg, P. D. & Kjelleberg, S., 1996, In: Journal of Bacteriology. 178, 22, p. 6618-22 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Secretion of Serratia liquefaciens phospholipase from Escherichia coli

      Givskov, Michael & Molin, S., 1993, In: Molecular Microbiology. 8, 2, p. 229-42 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1

      Givskov, Michael, Ostling, J., Eberl, L., Lindum, P. W., Christensen, A. B., Christiansen, G., Molin, S. & Kjelleberg, S., 1998, In: Journal of Bacteriology. 180, 3, p. 742-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Induction of phospholipase- and flagellar synthesis in Serratia liquefaciens is controlled by expression of the flagellar master operon flhD

      Givskov, Michael, Eberl, L., Christiansen, G., Benedik, M. J. & Molin, S., 1995, In: Molecular Microbiology. 15, 3, p. 445-54 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Responses to nutrient starvation in Pseudomonas putida KT2442: analysis of general cross-protection, cell shape, and macromolecular content

      Givskov, Michael, Eberl, L., Møller, S., Poulsen, L. K. & Molin, S., 1994, In: Journal of Bacteriology. 176, 1, p. 7-14 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Beyond nutrition: health-promoting foods by quorum-sensing inhibition

      Givskov, Michael, 2012, In: Future Microbiology. 7, 9, p. 1025-1028 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Associational Resistance to Predation by Protists in a Mixed Species Biofilm

      Goh, Y. F., Røder, Henriette Lyng, Chan, S. H., Ismail, M. H., Madsen, Jonas Stenløkke, Lee, K. W. K., Sørensen, Søren Johannes, Givskov, Michael, Burmølle, Mette, Rice, S. A. & McDougald, D., 2023, In: Applied and Environmental Microbiology. 89, 2, 16 p., e0174122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Inhibitory Effects of Secondary Metabolites from the Red Alga Delisea pulchra on Swarming Motility of Proteus mirabilis

      Gram, L., de Nys, R., Maximilien, R., Givskov, Michael, Steinberg, P. & Kjelleberg, S., 1996, In: Applied and Environmental Microbiology. 62, 11, p. 4284-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods

      Gram, L., Christensen, A. B., Ravn, L., Molin, S. & Givskov, Michael, 1999, In: Applied and Environmental Microbiology. 65, 8, p. 3458-63 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Food spoilage--interactions between food spoilage bacteria

      Gram, L., Ravn, L., Rasch, M., Bruhn, J. B., Christensen, A. B. & Givskov, Michael, 2002, In: International Journal of Food Microbiology. 78, 1-2, p. 79-97 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      High-throughput screening for compounds that modulate the cellular c-di-GMP level in bacteria

      Groizeleau, J., Andersen, Jens Bo, Givskov, Michael, Berthelsen, J. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 455-470 16 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    30. Published

      The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

      Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      A possible correlation between periodontitis and ischaemic heart disease

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

      Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

      Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

      Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

      Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Transcriptome analysis of Pseudomonas aeruginosa biofilm development: Anaerobic respiration and iron limitation

      Hentzer, M., Eberl, L. & Givskov, Michael, 2005, In: Biofilms. 2, 1, p. 37-61 25 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Targeting quorum sensing for treatment of chronic bacterial biofilm infections

      Hentzer, M., Givskov, Michael & Parsek, M. R., 2002, In: Laboratory Medicine. 33, 4, p. 295-306 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    39. Published

      Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

      Hentzer, M., Wu, H., Andersen, Jens Bo, Riedel, K., Rasmussen, T. B., Bagge, N., Kumar, N., Schembri, M. A., Song, Z., Kristoffersen, P., Manefield, M., Costerton, J. W., Molin, S., Eberl, L., Steinberg, P., Kjelleberg, S., Høiby, Niels & Givskov, Michael, 2003, In: EMBO Journal. 22, 15, p. 3803-15 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Quorum sensing : a novel target for the treatment of biofilm infections

      Hentzer, M., Eberl, L., Nielsen, J. & Givskov, Michael, 2003, In: BioDrugs. 17, 4, p. 241-50 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

      Hentzer, M. & Givskov, Michael, 2003, In: Journal of Clinical Investigation. 112, 9, p. 1300-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function

      Hentzer, M., Teitzel, G. M., Balzer, G. J., Heydorn, A., Molin, S., Givskov, Michael & Parsek, M. R., 2001, In: Journal of Bacteriology. 183, 18, p. 5395-401 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound

      Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, Jens Bo, Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, Niels, Kjelleberg, S. & Givskov, Michael, 2002, In: Microbiology. 148, Pt 1, p. 87-102 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Quantification of biofilm structures by the novel computer program COMSTAT

      Heydorn, A., Nielsen, A. T., Hentzer, M., Sternberg, C., Givskov, Michael, Ersbøll, B. K. & Molin, S., 2000, In: Microbiology. 146 ( Pt 10), p. 2395-407 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Experimental reproducibility in flow-chamber biofilms

      Heydorn, A., Ersbøll, B. K., Hentzer, M., Parsek, M. R., Givskov, Michael & Molin, S., 2000, In: Microbiology. 146 ( Pt 10), p. 2409-15 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Expedient total synthesis of pyrrothine natural products and analogs

      Hjelmgaard, T., Givskov, Michael & Nielsen, J., 2006, In: Organic & Biomolecular Chemistry. 5, 2, p. 344-8 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity

      Hjelmgaard, T., Persson, T., Rasmussen, T. B., Givskov, Michael & Nielsen, J., 2003, In: Bioorganic & Medicinal Chemistry. 11, 15, p. 3261-71 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Erratum: Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis (Infection and Immunity (2005) 73, 4 (2504-2514))

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, Aug 2005, In: Infection and Immunity. 73, 8, p. 5290 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    49. Published

      Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, 2005, In: Infection and Immunity. 73, 4, p. 2504-14 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice

      Hoffmann, N., Lee, B., Hentzer, M., Rasmussen, T. B., Song, Z., Johansen, H. K., Givskov, Michael & Høiby, N., 2007, In: Antimicrobial Agents and Chemotherapy. 51, 10, p. 3677-87 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 5838523