Michael Givskov

Michael Givskov

Professor

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    ORCID: 0000-0001-5004-8609

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    1. Published

      Early IL-2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN-dominating response and reduced lung pathology

      Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Bjarnsholt, Thomas, Givskov, Michael & Høiby, Niels, 2020, In: APMIS - Journal of Pathology, Microbiology and Immunology. 128, 12, p. 647-653

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Effects of Radix Ginseng on microbial infections: a narrative review

      Wu, H., Høiby, Niels, Yang, L., Givskov, Michael & Song, Z., Apr 2014, In: Journal of Traditional Chinese Medicine. 34, 2, p. 227-233 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo

      Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, Morten Levin, Seliktar, D., Kofidis, T., Høiby, Niels, Tolker-Nielsen, Tim, Song, Z. & Givskov, Michael, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

      Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation

      Wu, H., Lee, B., Yang, L., Wang, H., Givskov, Michael, Molin, S., Høiby, Niels & Song, Z., 1 Jun 2011, In: F E M S Immunology and Medical Microbiology. 62, 1, p. 49-56 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa

      Yang, L., Barken, K. B., Skindersoe, M. E., Christensen, A. B., Givskov, Michael & Tolker-Nielsen, T., 2007, In: Microbiology. 153, Pt 5, p. 1318-28 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa

      Wu, H., Song, Z., Givskov, Michael & Høiby, N., 2004, In: Microbes and Infection. 6, 1, p. 34-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

      Yam, J. K. H., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Salido, M. M. S., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Boo, Z. Z., Wu, B., Kjelleberg, S., Tolker-Nielsen, T., Lakshminarayanan, R., Beuerman, R. W., Yang, L. & 1 others, Givskov, Michael, 2022, In: Infection and Immunity. 90, 8

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Emerging frontiers in detection and control of bacterial biofilms

      Tan, S. Y. E., Chew, S. C., Tan, S. Y. Y., Givskov, Michael & Yang, L., 2014, In: Current Opinion in Biotechnology. 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells

      Wang, V. B., Chua, S., Cao, B., Seviour, T., Nesatyy, V. J., Marsili, E., Kjelleberg, S., Givskov, Michael, Tolker-Nielsen, Tim, Song, H., Loo, J. S. C. & Yang, L., 2013, In: PLOS ONE. 8, 5, p. e63129 7 p., e63129.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Enhancer-binding proteins with a forkhead-associated domain and the sigma54 regulon in Myxococcus xanthus fruiting body development

      Jelsbak, L., Givskov, Michael & Kaiser, D., 2005, In: Proceedings of the National Academy of Science of the United States of America. 102, 8, p. 3010-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Erratum: Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis (Infection and Immunity (2005) 73, 4 (2504-2514))

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, Aug 2005, In: Infection and Immunity. 73, 8, p. 5290 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    13. Published

      Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.

      Research output: Contribution to journal › Comment/debate › Research

    14. Establishment of new genetic traits in a microbial biofilm community

      Christensen, B. B., Sternberg, C., Andersen, J. B., Eberl, L., Moller, S., Givskov, Michael & Molin, S., 1998, In: Applied and Environmental Microbiology. 64, 6, p. 2247-55 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

      Givskov, Michael, de Nys, R., Manefield, M., Gram, L., Maximilien, R., Eberl, L., Molin, S., Steinberg, P. D. & Kjelleberg, S., 1996, In: Journal of Bacteriology. 178, 22, p. 6618-22 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein

      Manefield, M., de Nys, R., Kumar, N., Read, R., Givskov, Michael, Steinberg, P. & Kjelleberg, S., 1999, In: Microbiology. 145 ( Pt 2), p. 283-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Expedient total synthesis of pyrrothine natural products and analogs

      Hjelmgaard, T., Givskov, Michael & Nielsen, J., 2006, In: Organic & Biomolecular Chemistry. 5, 2, p. 344-8 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Experimental reproducibility in flow-chamber biofilms

      Heydorn, A., Ersbøll, B. K., Hentzer, M., Parsek, M. R., Givskov, Michael & Molin, S., 2000, In: Microbiology. 146 ( Pt 10), p. 2409-15 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation

      Dueholm, M. S., Søndergaard, M., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, Michael, Tolker-Nielsen, Tim, Otzen, D. & Nielsen, P. H., 18 Mar 2013, In: MicrobiologyOpen. 2, p. 365-382 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed and regulated by anaerobiosis

      Givskov, Michael & Molin, S., 1992, In: Molecular Microbiology. 6, 10, p. 1363-74 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

      Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      First case of E anophelis outbreak in an intensive-care unit

      Teo, J., Tan, S. Y. Y., Tay, M., Ding, Y., Kjelleberg, S., Givskov, Michael, Lin, R. T. P. & Yang, L., 2013, In: The Lancet. 382, 9895, p. 855-856 2 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    23. Published

      Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa.

      Rybtke, Morten Levin, Borlee, B. R., Murakami, K., Irie, Y., Hentzer, M., Nielsen, T. E., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, 2012, In: Applied and Environmental Microbiology. 78, 15, p. 5060-5069 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa

      Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Food spoilage--interactions between food spoilage bacteria

      Gram, L., Ravn, L., Rasch, M., Bruhn, J. B., Christensen, A. B. & Givskov, Michael, 2002, In: International Journal of Food Microbiology. 78, 1-2, p. 79-97 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing.

      Høiby, Niels, Johansen, Helle Krogh, Ciofu, Oana, Jensen, Peter Østrup, Bjarnsholt, Thomas & Givskov, Michael, 2007, In: Ugeskrift for læger. 169, 48, p. 4163-6 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Functional Amyloids Keep Quorum-sensing Molecules in Check

      Seviour, T., Hansen, S. H., Yang, L., Yau, Y. H., Wang, V. B., Stenvang, M. R., Christiansen, G., Marsili, E., Givskov, Michael, Chen, Y., Otzen, D. E., Nielsen, P. H., Geifman-Shochat, S., Kjelleberg, S. & Dueholm, M. S., 6 Mar 2015, In: Journal of Biological Chemistry. 290, 10, p. 6457-6469 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Furanones

      de Nys, R., Givskov, Michael, Kumar, N., Kjelleberg, S. & Steinberg, P. D., 2006, In: Progress in Molecular and Subcellular Biology. 42, p. 55-86 31 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

      Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial

      Smyth, A. R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., Holland, E. D., Givskov, Michael, Williams, P., Cámara, M., Barrett, D. A. & Knox, A., 1 Apr 2010, In: Pediatric Pulmonology. 45, 4, p. 356-62 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.

      Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

      Bjarnsholt, T., Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H., Rygaard, J., Moser, C., Eberl, L., Høiby, N. & Givskov, Michael, 2005, In: Microbiology. 151, Pt 12, p. 3873-80 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Gauging and visualizing c-di-GMP levels in pseudomonas aeruginosa using fluorescence-based biosensors

      Rybtke, Morten Levin, Chua, S. L., Yam, J. K. H., Givskov, Michael, Yang, L. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 87-98 12 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    34. Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111

      Huber, B., Riedel, K., Köthe, M., Givskov, Michael, Molin, S. & Eberl, L., 2002, In: Molecular Microbiology. 46, 2, p. 411-26 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Genetic and chemical tools for investigating signaling processes in biofilms

      Charlton, T., Givskov, Michael, deNys, R., Andersen, Jens Bo, Hentzer, M., Rice, S. & Kjelleberg, S., 2001, In: Methods in Enzymology. 336, p. 108-28 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora

      Manefield, M., Welch, M., Givskov, Michael, Salmond, G. P. & Kjelleberg, S., 2001, In: F E M S Microbiology Letters. 205, 1, p. 131-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover

      Manefield, M., Rasmussen, T. B., Henzter, M., Andersen, Jens Bo, Steinberg, P., Kjelleberg, S. & Givskov, Michael, 2002, In: Microbiology. 148, Pt 4, p. 1119-27 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

      Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      High-throughput screening for compounds that modulate the cellular c-di-GMP level in bacteria

      Groizeleau, J., Andersen, Jens Bo, Givskov, Michael, Berthelsen, J. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 455-470 16 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    40. Published

      How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1

      Rasmussen, T. B., Manefield, M., Andersen, Jens Bo, Eberl, L., Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S. & Givskov, Michael, 2000, In: Microbiology. 146 Pt 12, p. 3237-44 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Identification and characterization of a GDSL esterase gene located proximal to the swr quorum-sensing system of Serratia liquefaciens MG1

      Riedel, K., Talker-Huiber, D., Givskov, Michael, Schwab, H. & Eberl, L., 2003, In: Applied and Environmental Microbiology. 69, 7, p. 3901-10 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Identification and characterization of an N-acylhomoserine lactone-dependent quorum-sensing system in Pseudomonas putida strain IsoF

      Steidle, A., Allesen-Holm, M., Riedel, K., Berg, G., Givskov, Michael, Molin, S. & Eberl, L., 2002, In: Applied and Environmental Microbiology. 68, 12, p. 6371-82 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Identification and characterization of mutations responsible for a runaway replication phenotype of plasmid R1

      Givskov, Michael, Stougaard, P., Light, J. & Molin, S., 1987, In: Gene. 57, 2-3, p. 203-11 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts

      Schwager, S., Agnoli, K., Köthe, M., Feldmann, F., Givskov, Michael, Carlier, A. & Eberl, L., 2013, In: Infection and Immunity. 81, 1, p. 143-53 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Identification of LasR ligands through a virtual screening approach

      Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database

      Tan, S. Y. Y., Chua, S. L., Chen, Y., Rice, S. A., Kjelleberg, S., Nielsen, Thomas Eiland, Yang, L. & Givskov, Michael, Nov 2013, In: Antimicrobial Agents and Chemotherapy. 57, 11, p. 5629-5641 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics

      Arevalo-Ferro, C., Hentzer, M., Reil, G., Görg, A., Kjelleberg, S., Givskov, Michael, Riedel, K. & Eberl, L., 2003, In: Environmental Microbiology. 5, 12, p. 1350-69 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Identity and effects of quorum-sensing inhibitors produced by Penicillium species

      Rasmussen, T. B., Skindersoe, M. E., Bjarnsholt, T., Phipps, R. K., Christensen, K. B., Jensen, Peter Østrup, Andersen, Jens Bo, Koch, B., Larsen, T. O., Hentzer, M., Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: Microbiology. 151, Pt 5, p. 1325-40 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Imaging N-acyl homoserine lactone quorum sensing in vivo

      Hultqvist, Louise Dahl, Alhede, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    51. Published

      Imaging N-acyl homoserine lactone quorum sensing in vivo

      Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model

      Hultqvist, Louise Dahl, Moser, C., Jensen, Peter Østrup, Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

      Roizman, D., Vidaillac, C., Givskov, Michael & Yang, L., 2017, In: Antimicrobial Agents and Chemotherapy. 61, 10, 5 p., e01088-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      In silico analyses of metagenomes from human atherosclerotic plaque samples

      Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. In situ gene expression in mixed-culture biofilms: evidence of metabolic interactions between community members

      Møller, S., Sternberg, C., Andersen, J. B., Christensen, B. B., Ramos, J. L., Givskov, Michael & Molin, S., 1998, In: Applied and Environmental Microbiology. 64, 2, p. 721-32 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      In vitro and In vivo efficacy of an LpxC inhibitor, CHIR-090, alone or combined with colistin against Pseudomonas aeruginosa biofilm

      Tan, J. H., Vidaillac, C., Yam, J. K. H., Chua, S. L., Givskov, Michael & Yang, L., 2017, In: Antimicrobial Agents and Chemotherapy. 61, 7, 9 p., e02223-16.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

      Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      In-frame and unmarked gene deletions in Burkholderia cenocepacia via an allelic exchange system compatible with gateway technology

      Fazli, M., Harrison, J. J., Gambino, M., Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Applied and Environmental Microbiology. 81, 11, p. 3623-3630 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Inactivation of gltB abolishes expression of the assimilatory nitrate reductase gene (nasB) in Pseudomonas putida KT2442

      Eberl, L., Ammendola, A., Rothballer, M. H., Givskov, Michael, Sternberg, C., Kilstrup, M., Schleifer, K. H. & Molin, S., 2000, In: Journal of Bacteriology. 182, 12, p. 3368-76 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

      Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

      Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

      Teh, W. K., Dramsi, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Induction of phospholipase- and flagellar synthesis in Serratia liquefaciens is controlled by expression of the flagellar master operon flhD

      Givskov, Michael, Eberl, L., Christiansen, G., Benedik, M. J. & Molin, S., 1995, In: Molecular Microbiology. 15, 3, p. 445-54 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Influence of food preservation parameters and associated microbiota on production rate, profile and stability of acylated homoserine lactones from food-derived Enterobacteriaceae

      Ravn Flodgaard, L., Christensen, A. B., Molin, S., Givskov, Michael & Gram, L., 2003, In: International Journal of Food Microbiology. 84, 2, p. 145-56 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

      Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

      Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound

      Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, Jens Bo, Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, Niels, Kjelleberg, S. & Givskov, Michael, 2002, In: Microbiology. 148, Pt 1, p. 87-102 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Inhibitory Effects of Secondary Metabolites from the Red Alga Delisea pulchra on Swarming Motility of Proteus mirabilis

      Gram, L., de Nys, R., Maximilien, R., Givskov, Michael, Steinberg, P. & Kjelleberg, S., 1996, In: Applied and Environmental Microbiology. 62, 11, p. 4284-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo

      van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Interfering with bacterial gossip.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    73. Published

      Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

      Woetmann, Anders , Alhede, M., Dabelsteen, Sally, Bjarnsholt, Thomas, Rybtke, Morten Levin, Nastasi, C., Krejsgaard, T., Andersen, Mads Hald, Bonefeld, Charlotte Menne, Geisler, Carsten, Givskov, Michael & Ødum, Niels, 2018, In: OncoTarget. 9, 28, p. 19481-19489 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens

      Eberl, L., Winson, M. K., Sternberg, C., Stewart, G. S., Christiansen, G., Chhabra, S. R., Bycroft, B., Williams, P. F., Molin, S. & Givskov, Michael, 1996, In: Molecular Microbiology. 20, 1, p. 127-36 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Involvement of bacterial quorum-sensing signals in spoilage of bean sprouts

      Rasch, M., Andersen, Jens Bo, Nielsen, K. F., Flodgaard, L. R., Christensen, Henrik, Givskov, Michael & Gram, L., 2005, In: Applied and Environmental Microbiology. 71, 6, p. 3321-30 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

      Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

      Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Kinase Inhibitors

      Wu, P., Givskov, Michael & Nielsen, Thomas Eiland, 2017, Drug Selectivity: An Evolving Concept in Medicinal Chemistry. Wiley-Interscience, p. 33-53 21 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    79. Published

      Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

      Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Lipopeptide production in Pseudomonas sp. strain DSS73 is regulated by components of sugar beet seed exudate via the Gac two-component regulatory system

      Koch, B., Nielsen, T. H., Sørensen, D., Andersen, J. B., Christophersen, C., Molin, S., Givskov, Michael, Sørensen, J. & Nybroe, O., 2002, In: Applied and Environmental Microbiology. 68, 9, p. 4509-16 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA

      Laux, D. C., Corson, J. M., Givskov, Michael, Hentzer, M., Møller, A., Wosencroft, K. A., Olson, J. C., Krogfelt, K. A., Goldberg, J. B. & Cohen, P., 2002, In: Microbiology. 148, Pt 6, p. 1709-23 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus

      Chew, S. C., Yam, J. K. H., Matysik, A., Seng, Z. J., Klebensberger, J., Givskov, Michael, Doyle, P., Rice, S. A., Yang, L. & Kjelleberg, S., 2018, In: mBio. 9, 6, 16 p., e00585-18.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

      Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Methods for detecting acylated homoserine lactones produced by Gram-negative bacteria and their application in studies of AHL-production kinetics

      Ravn, L., Christensen, A. B., Molin, S., Givskov, Michael & Gram, L., 2001, In: Journal of Microbiological Methods. 44, 3, p. 239-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Microbiological aspects of phyllosoma rearing of the ornate rock lobster Panulirus ornatus

      Bourne, D., Høj, L., Webster, N., Payne, M., Skindersøe, M., Givskov, Michael & Hall, M., 22 Aug 2007, In: Aquaculture. 268, 1-4 SPEC. ISS., p. 274-287 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Molecular characterization of the pH-inducible and growth phase-dependent promoter P170 of Lactococcus lactis

      Madsen, S. M., Arnau, J., Vrang, A., Givskov, Michael & Israelsen, H., 1999, In: Molecular Microbiology. 32, 1, p. 75-87 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Molecular tools for study of biofilm physiology

      Christensen, B. B., Sternberg, C., Andersen, J. B., Palmer, R. J., Nielsen, A. T., Givskov, Michael & Molin, S., 1999, In: Methods in Enzymology. 310, p. 20-42 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.

      Mathee, K., Ciofu, Oana, Sternberg, C., Lindum, P. W., Campbell, J. I., Jensen, P., Johnsen, A. H., Givskov, Michael, Ohman, D. E., Molin, S., Høiby, Niels & Kharazmi, A., 1999, In: Microbiology. 145 ( Pt 6), p. 1349-57 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

      Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1

      Lindum, P. W., Anthoni, U., Christophersen, C., Eberl, L., Molin, S. & Givskov, Michael, 1998, In: Journal of Bacteriology. 180, 23, p. 6384-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      N-acyl homoserinelactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms

      Riedel, K., Mentzer, M., Geisenberger, O., Huber, B., Steidle, A., Wu, H., Høiby, Niels, Givskov, Michael, Molin, S. & Eberl, L., 2001, In: Microbiology. 147, p. 3249-3262

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. N-acyl-L-homoserine lactone-mediated regulation of the lip secretion system in Serratia liquefaciens MG1

      Riedel, K., Ohnesorg, T., Krogfelt, K. A., Hansen, T. S., Omori, K., Givskov, Michael & Eberl, L., 2001, In: Journal of Bacteriology. 183, 5, p. 1805-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms

      Riedel, K., Hentzer, M., Geisenberger, O., Huber, B., Steidle, A., Wu, H., Høiby, Niels, Givskov, Michael, Molin, S. & Eberl, L., 2001, In: Microbiology. 147, Pt 12, p. 3249-62 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria

      Andersen, J. B., Sternberg, C., Poulsen, L. K., Bjorn, S. P., Givskov, Michael & Molin, S., 1998, In: Applied and Environmental Microbiology. 64, 6, p. 2240-6 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Nonbioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-Hydroxyoctanoyl)homoserine lactone

      Flodgaard, L. R., Dalgaard, P., Andersen, Jens Bo, Nielsen, K. F., Givskov, Michael & Gram, L., 2005, In: Applied and Environmental Microbiology. 71, 4, p. 2113-20 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model

      Bragonzi, A., Worlitzsch, D., Pier, G. B., Timpert, P., Ulrich, M., Hentzer, M., Andersen, Jens Bo, Givskov, Michael, Conese, M. & Doring, G., 2005, In: Journal of Infectious Diseases. 192, 3, p. 410-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, B., Andersen, A. S., Krogfelt, K. A., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Journal of Clinical Microbiology. 47, 12, p. 4084-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Novel and future treatment strategies

      Alhede, M., Jakobsen, Tim Holm & Givskov, Michael, 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    100. Published

      Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis.

      Moser, Claus Ernst, van Gennip, M., Bjarnsholt, Thomas, Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, Henrik Pierre, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2009, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 117, p. 95-107 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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