Michael Givskov
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N, 22 Bygning 22, Building: 22-2-22
Member of:
- Published
Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence
Ferreira, A. A., Silva, I. I., Oliveira, V. V., Becker, J. J., Givskov, Michael, Ryan, R. R., Fernandes, F. & Moreira, L. M., May 2013, In: Applied and Environmental Microbiology. 79, 9, p. 3009-3020 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils
Fexby, S., Bjarnsholt, Thomas, Jensen, Peter Østrup, Roos, V., Høiby, Niels, Givskov, Michael & Klemm, P., 2006, In: Infection and Immunity. 75, 1, p. 30-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combining the Petasis 3-Component Reaction with Multiple Modes of Cyclization: A Build/Couple/Pair Strategy for the Synthesis of Densely Functionalized Small Molecules
Flagstad, T., Hansen, M. R., Le Quementt, S. T., Givskov, Michael & Nielsen, T. E., Jan 2015, In: A C S Combinatorial Science. 17, 1, p. 19-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors
Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics
Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, Thomas Eiland, 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nonbioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-Hydroxyoctanoyl)homoserine lactone
Flodgaard, L. R., Dalgaard, P., Andersen, Jens Bo, Nielsen, K. F., Givskov, Michael & Gram, L., 2005, In: Applied and Environmental Microbiology. 71, 4, p. 2113-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing
Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Wu, B., Su, H. & Yang, L., 2017, bioRxiv, 27 p.Research output: Working paper › Preprint › Research
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Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.Research output: Contribution to journal › Journal article › Research › peer-review
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Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227Research output: Contribution to journal › Journal article › Research › peer-review
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Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa
Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, Thomas Eiland, Givskov, Michael, Liu, X., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.Research output: Contribution to journal › Journal article › Research › peer-review
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The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells
Gall Mas, Laura, Fabbri, A., Namini, Martin Rich Javadi, Givskov, Michael, Fiorentini, C. & Krejsgaard, T., 2018, In: International Journal of Molecular Sciences . 19, 5, 11 p., 1408.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing regulation in Aeromonas hydrophila
Garde, C., Bjarnsholt, Thomas, Givskov, Michael, Jakobsen, Tim Holm, Hentzer, M., Claussen, A., Sneppen, K., Ferkinghoff-Borg, J. & Sams, T., 2010, In: Journal of Molecular Biology. 396, 4, p. 849-57 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis
Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: F E M S Microbiology Letters. 184, 2, p. 273-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Production of N-acyl-L-homoserine lactones by Pseudomonas aeruginosa isolates from chronic lung infections associated with cystic fibrosis
Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: FEMS Microbiology Letters. 184, p. 273-278Research output: Contribution to journal › Journal article › Research › peer-review
Copy mutants of plasmid R1: effects of base pair substitutions in the copA gene on the replication control system
Givskov, Michael & Molin, S., 1984, In: Molecular and General Genetics MGG. 194, 1-2, p. 286-92 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification and characterization of mutations responsible for a runaway replication phenotype of plasmid R1
Givskov, Michael, Stougaard, P., Light, J. & Molin, S., 1987, In: Gene. 57, 2-3, p. 203-11 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cloning and expression in Escherichia coli of the gene for extracellular phospholipase A1 from Serratia liquefaciens
Givskov, Michael, Olsen, L. & Molin, S., 1988, In: Journal of Bacteriology. 170, 12, p. 5855-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed and regulated by anaerobiosis
Givskov, Michael & Molin, S., 1992, In: Molecular Microbiology. 6, 10, p. 1363-74 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling
Givskov, Michael, de Nys, R., Manefield, M., Gram, L., Maximilien, R., Eberl, L., Molin, S., Steinberg, P. D. & Kjelleberg, S., 1996, In: Journal of Bacteriology. 178, 22, p. 6618-22 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Secretion of Serratia liquefaciens phospholipase from Escherichia coli
Givskov, Michael & Molin, S., 1993, In: Molecular Microbiology. 8, 2, p. 229-42 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1
Givskov, Michael, Ostling, J., Eberl, L., Lindum, P. W., Christensen, A. B., Christiansen, G., Molin, S. & Kjelleberg, S., 1998, In: Journal of Bacteriology. 180, 3, p. 742-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Induction of phospholipase- and flagellar synthesis in Serratia liquefaciens is controlled by expression of the flagellar master operon flhD
Givskov, Michael, Eberl, L., Christiansen, G., Benedik, M. J. & Molin, S., 1995, In: Molecular Microbiology. 15, 3, p. 445-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Responses to nutrient starvation in Pseudomonas putida KT2442: analysis of general cross-protection, cell shape, and macromolecular content
Givskov, Michael, Eberl, L., Møller, S., Poulsen, L. K. & Molin, S., 1994, In: Journal of Bacteriology. 176, 1, p. 7-14 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beyond nutrition: health-promoting foods by quorum-sensing inhibition
Givskov, Michael, 2012, In: Future Microbiology. 7, 9, p. 1025-1028 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associational Resistance to Predation by Protists in a Mixed Species Biofilm
Goh, Y. F., Røder, Henriette Lyng, Chan, S. H., Ismail, M. H., Madsen, Jonas Stenløkke, Lee, K. W. K., Sørensen, Søren Johannes, Givskov, Michael, Burmølle, Mette, Rice, S. A. & McDougald, D., 2023, In: Applied and Environmental Microbiology. 89, 2, 16 p., e0174122.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibitory Effects of Secondary Metabolites from the Red Alga Delisea pulchra on Swarming Motility of Proteus mirabilis
Gram, L., de Nys, R., Maximilien, R., Givskov, Michael, Steinberg, P. & Kjelleberg, S., 1996, In: Applied and Environmental Microbiology. 62, 11, p. 4284-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods
Gram, L., Christensen, A. B., Ravn, L., Molin, S. & Givskov, Michael, 1999, In: Applied and Environmental Microbiology. 65, 8, p. 3458-63 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Food spoilage--interactions between food spoilage bacteria
Gram, L., Ravn, L., Rasch, M., Bruhn, J. B., Christensen, A. B. & Givskov, Michael, 2002, In: International Journal of Food Microbiology. 78, 1-2, p. 79-97 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-throughput screening for compounds that modulate the cellular c-di-GMP level in bacteria
Groizeleau, J., Andersen, Jens Bo, Givskov, Michael, Berthelsen, J. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 455-470 16 p. (Methods in Molecular Biology, Vol. 1657).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation
Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A possible correlation between periodontitis and ischaemic heart disease
Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.Research output: Contribution to journal › Journal article › Research › peer-review
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Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom
Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay
Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction
Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators
Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa
Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptome analysis of Pseudomonas aeruginosa biofilm development: Anaerobic respiration and iron limitation
Hentzer, M., Eberl, L. & Givskov, Michael, 2005, In: Biofilms. 2, 1, p. 37-61 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting quorum sensing for treatment of chronic bacterial biofilm infections
Hentzer, M., Givskov, Michael & Parsek, M. R., 2002, In: Laboratory Medicine. 33, 4, p. 295-306 12 p.Research output: Contribution to journal › Review › Research › peer-review
Quorum sensing : a novel target for the treatment of biofilm infections
Hentzer, M., Eberl, L., Nielsen, J. & Givskov, Michael, 2003, In: BioDrugs. 17, 4, p. 241-50 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
Hentzer, M., Wu, H., Andersen, Jens Bo, Riedel, K., Rasmussen, T. B., Bagge, N., Kumar, N., Schembri, M. A., Song, Z., Kristoffersen, P., Manefield, M., Costerton, J. W., Molin, S., Eberl, L., Steinberg, P., Kjelleberg, S., Høiby, Niels & Givskov, Michael, 2003, In: EMBO Journal. 22, 15, p. 3803-15 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
Hentzer, M. & Givskov, Michael, 2003, In: Journal of Clinical Investigation. 112, 9, p. 1300-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function
Hentzer, M., Teitzel, G. M., Balzer, G. J., Heydorn, A., Molin, S., Givskov, Michael & Parsek, M. R., 2001, In: Journal of Bacteriology. 183, 18, p. 5395-401 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound
Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, Jens Bo, Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, Niels, Kjelleberg, S. & Givskov, Michael, 2002, In: Microbiology. 148, Pt 1, p. 87-102 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantification of biofilm structures by the novel computer program COMSTAT
Heydorn, A., Nielsen, A. T., Hentzer, M., Sternberg, C., Givskov, Michael, Ersbøll, B. K. & Molin, S., 2000, In: Microbiology. 146 ( Pt 10), p. 2395-407 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Experimental reproducibility in flow-chamber biofilms
Heydorn, A., Ersbøll, B. K., Hentzer, M., Parsek, M. R., Givskov, Michael & Molin, S., 2000, In: Microbiology. 146 ( Pt 10), p. 2409-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Expedient total synthesis of pyrrothine natural products and analogs
Hjelmgaard, T., Givskov, Michael & Nielsen, J., 2006, In: Organic & Biomolecular Chemistry. 5, 2, p. 344-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity
Hjelmgaard, T., Persson, T., Rasmussen, T. B., Givskov, Michael & Nielsen, J., 2003, In: Bioorganic & Medicinal Chemistry. 11, 15, p. 3261-71 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis (Infection and Immunity (2005) 73, 4 (2504-2514))
Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, Aug 2005, In: Infection and Immunity. 73, 8, p. 5290 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis
Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, 2005, In: Infection and Immunity. 73, 4, p. 2504-14 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice
Hoffmann, N., Lee, B., Hentzer, M., Rasmussen, T. B., Song, Z., Johansen, H. K., Givskov, Michael & Høiby, N., 2007, In: Antimicrobial Agents and Chemotherapy. 51, 10, p. 3677-87 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria
Holden, M. T., Ram Chhabra, S., de Nys, R., Stead, P., Bainton, N. J., Hill, P. J., Manefield, M., Kumar, N., Labatte, M., England, D., Rice, S., Givskov, Michael, Salmond, G. P., Stewart, G. S., Bycroft, B. W., Kjelleberg, S. & Williams, P. F., 1999, In: Molecular Microbiology. 33, 6, p. 1254-66 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity
Hoong Yam, J. K., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Santillan Salido, M. M., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Wu, B., Kjelleberg, S., Tolker-Nielsen, Tim, Beuerman, R. W., Givskov, Michael & Yang, L., 2017, bioRxiv, 35 p.Research output: Working paper › Preprint › Research
The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility
Huber, B., Riedel, K., Hentzer, M., Heydorn, A., Gotschlich, A., Givskov, Michael, Molin, S. & Eberl, L., 2001, In: Microbiology. 147, Pt 9, p. 2517-28 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111
Huber, B., Riedel, K., Köthe, M., Givskov, Michael, Molin, S. & Eberl, L., 2002, In: Molecular Microbiology. 46, 2, p. 411-26 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Imaging N-acyl homoserine lactone quorum sensing in vivo
Hultqvist, Louise Dahl, Alhede, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiotic resistance of bacterial biofilms
Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael, Molin, S. & Ciofu, Oana, 2010, In: International Journal of Antimicrobial Agents. 35, 4, p. 322-332 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients
Høiby, Niels, Johansen, Helle Krogh, Moser, Claus Ernst, Ciofu, Oana, Jensen, Peter Østrup, Kolpen, Mette, Mandsberg, L., Givskov, Michael, Molin, S. & Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer, p. 167-184 18 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The clinical impact of bacterial biofilms
Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65Research output: Contribution to journal › Journal article › Research › peer-review
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Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing.
Høiby, Niels, Johansen, Helle Krogh, Ciofu, Oana, Jensen, Peter Østrup, Bjarnsholt, Thomas & Givskov, Michael, 2007, In: Ugeskrift for læger. 169, 48, p. 4163-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A broad range quorum sensing inhibitor working through sRNA inhibition
Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.Research output: Contribution to journal › Journal article › Research › peer-review
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Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing
Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro
Jakobsen, Tim Holm, Alhede, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, , 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
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Qualitative and quantitative determination of quorum sensing inhibition in vitro
Jakobsen, Tim Holm, van Gennip, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 1 Jan 2011, In: Methods in Molecular Biology. 692, 3, p. 253-263 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.Research output: Contribution to journal › Review › Research › peer-review
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Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors
Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms
Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatially extensive microbial biogeography of the Indian Ocean provides insights into the unique community structure of a pristine coral atoll
Jeffries, T. C., Ostrowski, M., Williams, R. B., Xie, C., Jensen, R. M., Grzymski, J. J., Senstius, S. J., Givskov, Michael, Hoeke, R., Philip, G. K., Neches, R. Y., Drautz-Moses, D. I., Chenard, C., Paulsen, I. T. & Lauro, F. M., 20 Oct 2015, In: Scientific Reports. 5, 13 p., 15383 .Research output: Contribution to journal › Journal article › Research › peer-review
Enhancer-binding proteins with a forkhead-associated domain and the sigma54 regulon in Myxococcus xanthus fruiting body development
Jelsbak, L., Givskov, Michael & Kaiser, D., 2005, In: Proceedings of the National Academy of Science of the United States of America. 102, 8, p. 3010-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The immune system vs. Pseudomonas aeruginosa biofilms
Jensen, Peter Østrup, Givskov, Michael, Bjarnsholt, Thomas & Moser, C., 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 292-305 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa
Jensen, Peter Østrup, Bjarnsholt, Thomas, Phipps, R., Rasmussen, T. B., Calum, H., Christoffersen, L., Moser, C., Williams, P., Pressler, T., Givskov, Michael & Høiby, Niels, 2007, In: Microbiology. 153, Pt 5, p. 1329-38 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production
Kastbjerg, V. G., Nielsen, K. F., Dalsgaard, I., Rasch, M., Bruhn, J. B., Givskov, Michael & Gram, L., 2007, In: Journal of Applied Microbiology. 102, 2, p. 363-74 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11
Kim, J. Y., Sahu, S., Yau, Y. H., Wang, X., Shochat, S. G., Nielsen, P. H., Dueholm, M. S., Otzen, D. E., Lee, J., Delos Santos, M. M. S., Yam, J. K. H., Kang, N. Y., Park, S. J., Kwon, H., Seviour, T., Yang, L., Givskov, Michael & Chang, Y. T., 13 Jan 2016, In: Journal of the American Chemical Society. 138, 1, p. 402-407 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distribution, organization, and ecology of bacteria in chronic wounds
Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, M., Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Communication systems as targets for biological control
Kjelleberg, S. & Givskov, Michael, 2000, 1 ed. 1 p. (Environmental Microbiology).Research output: Book/Report › Book › Research
The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors
Koch, B., Liljefors, T., Persson, T., Nielsen, J., Kjelleberg, S. & Givskov, Michael, 2005, In: Microbiology. 151, Pt 11, p. 3589-602 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Lipopeptide production in Pseudomonas sp. strain DSS73 is regulated by components of sugar beet seed exudate via the Gac two-component regulatory system
Koch, B., Nielsen, T. H., Sørensen, D., Andersen, J. B., Christophersen, C., Molin, S., Givskov, Michael, Sørensen, J. & Nybroe, O., 2002, In: Applied and Environmental Microbiology. 68, 9, p. 4509-16 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination
Koh, A. Y., Mikkelsen, P. J., Smith, R. S., Coggshall, K. T., Kamei, A., Givskov, Michael, Lory, S. & Pier, G. B., 1 Dec 2010, In: P L o S One. 5, 12, p. e15131Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacteria-triggered release of antimicrobial agents
Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of Substituted γ- and δ-Lactams through Mannich-Type Reactions of Solid-Supported N-Acyliminium Ions
Komnatnyy, V. V., Taveras, K. M., Nandurkar, N. S., Le Quement, S. T., Givskov, Michael & Nielsen, T. E., Jun 2015, In: European Journal of Organic Chemistry. 2015, 16, p. 3524-3530 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence
Komnatnyy, V. V., Givskov, Michael & Nielsen, T. E., Dec 2012, In: Chemistry. A European Journal. 18, 52, p. 16793-16800 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Site-specific deletions of chromosomally located DNA segments with the multimer resolution system of broad-host-range plasmid RP4
Kristensen, C. S., Eberl, L., Sanchez-Romero, J. M., Givskov, Michael, Molin, S. & De Lorenzo, V., 1995, In: Journal of Bacteriology. 177, 1, p. 52-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump
Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells
Kristiansen, S., Bjarnsholt, Thomas, Adeltoft, D., Ifversen, P. & Givskov, Michael, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 116, 5, p. 361-371 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine
Krogfelt, K. A., Hjulgaard, M., Sørensen, K., Cohen, P. & Givskov, Michael, 2000, In: Infection and Immunity. 68, 5, p. 2518-24 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualizing biofilm by targeting eDNA with long wavelength probe CDr15
Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CDy14: A novel biofilm probe targeting exopolysaccharide Psl
Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cholesterol crystals enhance TLR2-and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis
Køllgaard, T. M. S., Enevold, Christian, Bendtzen, K., Hansen, Peter Riis, Givskov, Michael, Holmstrup, Palle & Nielsen, Claus Henrik, 24 Feb 2017, In: P L o S One. 12, 2, 14 p., 0172773.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent
Labbate, M., Zhu, H., Thung, L., Bandara, R., Larsen, M. R., Willcox, M. D. P., Givskov, Michael, Rice, S. A. & Kjelleberg, S., 2007, In: Journal of Bacteriology. 189, 7, p. 2702-11 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1
Labbate, M., Queck, S. Y., Koh, K. S., Rice, S. A., Givskov, Michael & Kjelleberg, S., 2004, In: Journal of Bacteriology. 186, 3, p. 692-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data
Lauro, F. M., Senstius, S. J., Cullen, J., Neches, R., Jensen, R. M., Brown, M. V., Darling, A. E., Givskov, Michael, McDougald, D., Hoeke, R., Ostrowski, M., Philip, G. K., Paulsen, I. T. & Grzymski, J. J., 2014, In: PLOS Biology. 12, 9Research output: Contribution to journal › Journal article › Research › peer-review
Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA
Laux, D. C., Corson, J. M., Givskov, Michael, Hentzer, M., Møller, A., Wosencroft, K. A., Olson, J. C., Krogfelt, K. A., Goldberg, J. B. & Cohen, P., 2002, In: Microbiology. 148, Pt 6, p. 1709-23 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones
Le Quement, S. T., Flagstad, T., Mikkelsen, R. J. T., Hansen, M. R., Givskov, Michael & Nielsen, T. E., 2012, In: Organic Letters. 14, 2, p. 640-643 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates
Leong, W., Lutz, C., Williams, J., Poh, Y. H., Ken Yee, B. Y., Chua, C., Rice, S. A., Givskov, Michael, Sanderson-Smith, M. & McDougald, D., 2020, bioRxiv, 49 p.Research output: Working paper › Preprint › Research
- Published
Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence
Leong, W., Poh, W. H., Williams, J., Lutz, C., Mozammel Hoque, M., Poh, Y. H., Yee, B. Y. K., Chua, C., Givskov, Michael, Sanderson-Smith, M., Rice, S. A. & McDougald, D., 2022, In: Applied and Environmental Microbiology. 88, 5, e02322.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen Elizabethkingia anophelis in Response to Oxidative Stress
Li, Y., Liu, Y., Chew, S. C., Tay, M., Salido, M. M. S., Teo, J., Lauro, F. M., Givskov, Michael & Yang, L., Jun 2015, In: Genome Biology and Evolution. 7, 6, p. 1676-1685 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5838523
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
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